Abstract
This study was conducted to examine the excitability of the nociceptive flexor reflex and its sensitization by repetitive stimulation of C-fibers in anesthetized mice that lack the galanin-R1 receptor. Repetitive stimulation of C-fibers induced a gradual increase in reflex magnitude during the stimulation (wind-up), and a subsequent increase in spinal reflex excitability (central sensitization). This occurred in GAL-R1 -/-, GAL-R1 +/-, and +/+ wild-type controls, with no significant differences observed between genotypes. Intrathecal administration of galanin markedly blocked the sensitization following the repetitive stimulation in all three groups. No differences between wild-type or galanin-R1 receptor knockout mice were seen. These results confirm previous studies in rats, showing that intrathecal galanin reduces the central sensitization following wind-up. The present data indicate that this effect is probably mediated by receptors other than GAL-R1.
Original language | English (US) |
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Pages (from-to) | 153-156 |
Number of pages | 4 |
Journal | Neuroscience Letters |
Volume | 345 |
Issue number | 3 |
DOIs | |
State | Published - Jul 24 2003 |
Externally published | Yes |
Keywords
- Central sensitization
- Intrathecal
- Knockout
- Nociception
- Pain
- Spinal cord
- Wind-up
ASJC Scopus subject areas
- Neuroscience(all)