Flexor reflex excitability in mice lacking galanin receptor galanin-R1

Stefan Grass, Arie S. Jacoby, Tiina P. Iismaa, Jacqueline Crawley, Xiao Jun Xu, Zsuzsanna Wiesenfeld-Hallin

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

This study was conducted to examine the excitability of the nociceptive flexor reflex and its sensitization by repetitive stimulation of C-fibers in anesthetized mice that lack the galanin-R1 receptor. Repetitive stimulation of C-fibers induced a gradual increase in reflex magnitude during the stimulation (wind-up), and a subsequent increase in spinal reflex excitability (central sensitization). This occurred in GAL-R1 -/-, GAL-R1 +/-, and +/+ wild-type controls, with no significant differences observed between genotypes. Intrathecal administration of galanin markedly blocked the sensitization following the repetitive stimulation in all three groups. No differences between wild-type or galanin-R1 receptor knockout mice were seen. These results confirm previous studies in rats, showing that intrathecal galanin reduces the central sensitization following wind-up. The present data indicate that this effect is probably mediated by receptors other than GAL-R1.

Original languageEnglish (US)
Pages (from-to)153-156
Number of pages4
JournalNeuroscience Letters
Volume345
Issue number3
DOIs
StatePublished - Jul 24 2003
Externally publishedYes

Keywords

  • Central sensitization
  • Intrathecal
  • Knockout
  • Nociception
  • Pain
  • Spinal cord
  • Wind-up

ASJC Scopus subject areas

  • Neuroscience(all)

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