Flavonoid-membrane interactions: A protective role of flavonoids at the membrane surface?

Patricia I. Oteiza, Alejandra G. Erlejman, Sandra V. Verstraeten, Carl L Keen, César G. Fraga

Research output: Contribution to journalArticle

230 Citations (Scopus)

Abstract

Flavonoids can exert beneficial health effects through multiple mechanisms. In this paper, we address the important, although not fully understood, capacity of flavonoids to interact with cell membranes. The interactions of polyphenols with bilayers include: (a) the partition of the more non-polar compounds in the hydrophobic interior of the membrane, and (b) the formation of hydrogen bonds between the polar head groups of lipids and the more hydrophilic flavonoids at the membrane interface. The consequences of these interactions are discussed. The induction of changes in membrane physical properties can affect the rates of membrane lipid and protein oxidation. The partition of certain flavonoids in the hydrophobic core can result in a chain breaking antioxidant activity. We suggest that interactions of polyphenols at the surface of bilayers through hydrogen bonding, can act to reduce the access of deleterious molecules (i.e. oxidants), thus protecting the structure and function of membranes.

Original languageEnglish (US)
Pages (from-to)19-25
Number of pages7
JournalClinical and Developmental Immunology
Volume12
Issue number1
DOIs
StatePublished - Mar 2005

Fingerprint

Flavonoids
Membranes
Polyphenols
Hydrogen Bonding
Membrane Lipids
Oxidants
Hydrogen
Membrane Proteins
Antioxidants
Cell Membrane
Lipids
Health

Keywords

  • Antioxidants
  • Biophysics
  • Flavonoids
  • Membranes
  • Polyphenols
  • Review

ASJC Scopus subject areas

  • Immunology
  • Cell Biology
  • Developmental Biology

Cite this

Flavonoid-membrane interactions : A protective role of flavonoids at the membrane surface? / Oteiza, Patricia I.; Erlejman, Alejandra G.; Verstraeten, Sandra V.; Keen, Carl L; Fraga, César G.

In: Clinical and Developmental Immunology, Vol. 12, No. 1, 03.2005, p. 19-25.

Research output: Contribution to journalArticle

Oteiza, Patricia I. ; Erlejman, Alejandra G. ; Verstraeten, Sandra V. ; Keen, Carl L ; Fraga, César G. / Flavonoid-membrane interactions : A protective role of flavonoids at the membrane surface?. In: Clinical and Developmental Immunology. 2005 ; Vol. 12, No. 1. pp. 19-25.
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