FISH-mapped CEPH YACs spanning 0 to 46 cM on human chromosome 6

P. Bray-Ward; Christopher Bowlus; J. Choi; D. Le Paslier; J. Weissenbach; J. R. Gruen

doi:10.1006/geno.1996.0430

FISH-mapped CEPH YACs spanning 0 to 46 cM on human chromosome 6

P. Bray-Ward, Christopher Bowlus, J. Choi, D. Le Paslier, J. Weissenbach, J. R. Gruen

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Seventy-six CEPH YACs were mapped by fluorescence in situ hybridization (FISH) to human metaphase chromosomes. These clones have been ordered from pter to 46 cM by combining the results of FISH with sequence-tagged site content mapping using data from the public databases. This created a minimal tiling path containing at least 37 Mb of human genomic DNA from 0 to 46 cM on chromosome 6 that contains up to four gaps not greater than 200 kb. These data provide an integration of the FLpter physical map values with cytogenetic band localization and markers on the genetic and radiation hybrid maps. We also assessed YAC chimerism and placed three additional Whitehead contigs (WC952, WC799, WC436) within the integrated map.

Original language	English (US)
Pages (from-to)	104-111
Number of pages	8
Journal	Genomics
Volume	36
Issue number	1
DOIs	https://doi.org/10.1006/geno.1996.0430
State	Published - Aug 15 1996
Externally published	Yes

ASJC Scopus subject areas

Genetics

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abstract = "Seventy-six CEPH YACs were mapped by fluorescence in situ hybridization (FISH) to human metaphase chromosomes. These clones have been ordered from pter to 46 cM by combining the results of FISH with sequence-tagged site content mapping using data from the public databases. This created a minimal tiling path containing at least 37 Mb of human genomic DNA from 0 to 46 cM on chromosome 6 that contains up to four gaps not greater than 200 kb. These data provide an integration of the FLpter physical map values with cytogenetic band localization and markers on the genetic and radiation hybrid maps. We also assessed YAC chimerism and placed three additional Whitehead contigs (WC952, WC799, WC436) within the integrated map.",

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AU - Bray-Ward, P.

AU - Bowlus, Christopher

AU - Choi, J.

AU - Paslier, D. Le

AU - Weissenbach, J.

AU - Gruen, J. R.

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