First report of clinical disease associated with canine distemper virus infection in a wild black bear (Ursus americana)

W. O. Cottrell, Michael K Keel, J. W. Brooks, D. G. Mead, J. E. Phillips

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

An approximately 1-yr-old black bear was discovered on the porch of a rural residence in southwestern Pennsylvania on October 26, 2011, where it remained during the day in spite of efforts to frighten it away. The bear exhibited periods of somnolence and sporadic tremors and seizures. It was euthanized by gunshot that evening. Immediately after euthanasia it was observed to have footpads that exuded fluid when compressed. It was submitted for necropsy the next day where roughened footpads were noted. Histo-logic examination of the brain demonstrated nonsuppurative encephalitis with eosinophilic intranuclear and intracytoplasmic inclusion bodies in neurons. The footpads were thickened and hyperkeratotic. Canine distemper virus (CDV) was detected by immunohisto-chemistry (IHC) in the brain and footpads, and by reverse transcription polymerase chain reaction (RT-PCR) from the brain tissue. Phylogenetic analysis indicated that the CDV cDNA from the bear had 98.2% nucleotide identity to the Rockborn-Candur vaccine and a canine isolate from 2004 in Missouri, USA, and 97.3% nucleotide identity to a raccoon CDV isolated in 2011 from Tennessee, USA. This represents a first report of CDV as a cause of encephalitis or footpad hyperkeratosis in a wild black bear.

Original languageEnglish (US)
Pages (from-to)1024-1027
Number of pages4
JournalJournal of Wildlife Diseases
Volume49
Issue number4
DOIs
StatePublished - Oct 2013

Fingerprint

Ursus
Canine distemper virus
Ursidae
bear
virus
encephalitis
brain
infection
nucleotides
hyperkeratosis
Procyon lotor
inclusion bodies
vaccine
euthanasia
seizures
polymerase chain reaction
necropsy
chemistry
neurons
reverse transcriptase polymerase chain reaction

Keywords

  • Black bear
  • Canine distemper
  • Clinical disease
  • Pennsylvania
  • Ursidae

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Ecology

Cite this

First report of clinical disease associated with canine distemper virus infection in a wild black bear (Ursus americana). / Cottrell, W. O.; Keel, Michael K; Brooks, J. W.; Mead, D. G.; Phillips, J. E.

In: Journal of Wildlife Diseases, Vol. 49, No. 4, 10.2013, p. 1024-1027.

Research output: Contribution to journalArticle

Cottrell, W. O. ; Keel, Michael K ; Brooks, J. W. ; Mead, D. G. ; Phillips, J. E. / First report of clinical disease associated with canine distemper virus infection in a wild black bear (Ursus americana). In: Journal of Wildlife Diseases. 2013 ; Vol. 49, No. 4. pp. 1024-1027.
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