Fine mapping of a genetic locus for Peutz-Jeghers syndrome on chromosome 19p

C. I. Amos, D. Bali, T. J. Thiel, J. P. Anderson, I. Gourley, M. L. Frazier, P. M. Lynch, M. A. Luchtefeld, A. Young, T. J. McGarrity, Michael F Seldin

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85 Scopus citations

Abstract

Peutz-Jeghers syndrome (PJS) was recently mapped in a single report to the telomeric region of chromosome 19p (A. Hemminki et al., Nat. Genet., 15: 87-90, 1997). Our studies confirm this location and provide further localization of the PJS locus. In the five families examined, there were no recombinants with the marker D19S886. The multipoint log odds score at D19S886 is 7.52, and we found no evidence for genetic heterogeneity. We also found that all carriers expressed the PJS phenotype and no noncarriers displayed PJS sequellae, indicating complete penetrance with no sporadic cases.

Original languageEnglish (US)
Pages (from-to)3653-3656
Number of pages4
JournalCancer Research
Volume57
Issue number17
StatePublished - 1997
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Amos, C. I., Bali, D., Thiel, T. J., Anderson, J. P., Gourley, I., Frazier, M. L., Lynch, P. M., Luchtefeld, M. A., Young, A., McGarrity, T. J., & Seldin, M. F. (1997). Fine mapping of a genetic locus for Peutz-Jeghers syndrome on chromosome 19p. Cancer Research, 57(17), 3653-3656.