Filgrastim treatment of acute myelogenous leukemia (M7) relapse after allogeneic peripheral stem cell transplantation resulting in both graft-versus-leukemia effect with cytogenetic remission and chronic graft-versus-host disease manifesting as polyserositis and subsequent bronchiolitis obliterans with organizing pneumonia

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Abstract

Filgrastim (granulocyte colony-stimulating factor) has recently been reported to successfully treat patients with leukemic relapse after allogeneic peripheral stem cell transplantation (PSCT). However, the majority of the patients who responded also developed graft-versus-host disease (GVHD). Polyserositis as a manifestation of GVHD is a rare phenomenon. We report the first case of polyserositis following the use of filgrastim to treat a patient with acute myelogenous leukemia (M7), who had relapsed after an initially successful allogeneic PSCT. The polyserositis manifested with effusions and was initially controlled with high doses of steroids and pericardial stripping; however, after a quiescent period the patient eventually developed bronchiolitis obliterans with organizing pneumonia that required additional immunosuppressive therapy. We review the literature on GVHD-associated polyserositis and offer potential explanations for its pathogenesis.

Original languageEnglish (US)
Pages (from-to)360-364
Number of pages5
JournalInternational Journal of Hematology
Volume76
Issue number4
DOIs
StatePublished - Nov 2002

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Cryptogenic Organizing Pneumonia
Peripheral Blood Stem Cell Transplantation
Graft vs Host Disease
Acute Myeloid Leukemia
Cytogenetics
Leukemia
Transplants
Recurrence
Granulocyte Colony-Stimulating Factor
Therapeutics
Immunosuppressive Agents
Steroids
Filgrastim

Keywords

  • AML (M7)
  • Bronchiolitis obliterans with organizing pneumonia
  • Filgrastim
  • Graft-versus-host disease
  • Graft-versus-leukemia
  • Peripheral stem cell transplant
  • Polyserositis
  • Relapse

ASJC Scopus subject areas

  • Hematology

Cite this

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title = "Filgrastim treatment of acute myelogenous leukemia (M7) relapse after allogeneic peripheral stem cell transplantation resulting in both graft-versus-leukemia effect with cytogenetic remission and chronic graft-versus-host disease manifesting as polyserositis and subsequent bronchiolitis obliterans with organizing pneumonia",
abstract = "Filgrastim (granulocyte colony-stimulating factor) has recently been reported to successfully treat patients with leukemic relapse after allogeneic peripheral stem cell transplantation (PSCT). However, the majority of the patients who responded also developed graft-versus-host disease (GVHD). Polyserositis as a manifestation of GVHD is a rare phenomenon. We report the first case of polyserositis following the use of filgrastim to treat a patient with acute myelogenous leukemia (M7), who had relapsed after an initially successful allogeneic PSCT. The polyserositis manifested with effusions and was initially controlled with high doses of steroids and pericardial stripping; however, after a quiescent period the patient eventually developed bronchiolitis obliterans with organizing pneumonia that required additional immunosuppressive therapy. We review the literature on GVHD-associated polyserositis and offer potential explanations for its pathogenesis.",
keywords = "AML (M7), Bronchiolitis obliterans with organizing pneumonia, Filgrastim, Graft-versus-host disease, Graft-versus-leukemia, Peripheral stem cell transplant, Polyserositis, Relapse",
author = "L. Law and Joseph Tuscano and Theodore Wun and K. Ahlberg and Richman, {Carol M}",
year = "2002",
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AU - Law, L.

AU - Tuscano, Joseph

AU - Wun, Theodore

AU - Ahlberg, K.

AU - Richman, Carol M

PY - 2002/11

Y1 - 2002/11

N2 - Filgrastim (granulocyte colony-stimulating factor) has recently been reported to successfully treat patients with leukemic relapse after allogeneic peripheral stem cell transplantation (PSCT). However, the majority of the patients who responded also developed graft-versus-host disease (GVHD). Polyserositis as a manifestation of GVHD is a rare phenomenon. We report the first case of polyserositis following the use of filgrastim to treat a patient with acute myelogenous leukemia (M7), who had relapsed after an initially successful allogeneic PSCT. The polyserositis manifested with effusions and was initially controlled with high doses of steroids and pericardial stripping; however, after a quiescent period the patient eventually developed bronchiolitis obliterans with organizing pneumonia that required additional immunosuppressive therapy. We review the literature on GVHD-associated polyserositis and offer potential explanations for its pathogenesis.

AB - Filgrastim (granulocyte colony-stimulating factor) has recently been reported to successfully treat patients with leukemic relapse after allogeneic peripheral stem cell transplantation (PSCT). However, the majority of the patients who responded also developed graft-versus-host disease (GVHD). Polyserositis as a manifestation of GVHD is a rare phenomenon. We report the first case of polyserositis following the use of filgrastim to treat a patient with acute myelogenous leukemia (M7), who had relapsed after an initially successful allogeneic PSCT. The polyserositis manifested with effusions and was initially controlled with high doses of steroids and pericardial stripping; however, after a quiescent period the patient eventually developed bronchiolitis obliterans with organizing pneumonia that required additional immunosuppressive therapy. We review the literature on GVHD-associated polyserositis and offer potential explanations for its pathogenesis.

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KW - Graft-versus-host disease

KW - Graft-versus-leukemia

KW - Peripheral stem cell transplant

KW - Polyserositis

KW - Relapse

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