Fibronectin and tenascin-C: Accomplices in vascular morphogenesis during development and tumor growth

Ellen van Obberghen-Schilling, Richard P Tucker, Falk Saupe, Isabelle Gasser, Botond Cseh, Gertraud Orend

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

In addition to soluble factors, the extracellular matrix (ECM) also plays a vital role in normal vasculogenesis and in the pathological angiogenesis of many disease states. Here we will review what is known about the role of the ECM molecules fibronectin and tenascin-C in the vasculature and highlight a potential collaborative interplay between these molecules in developmental and tumorigenic angiogenesis. We will address the evolution of these modular proteins, their cellular interactions and how they become assembled into an insoluble matrix that impacts the assembly of other ECM proteins and the bioavailability of pro-angiogenic factors. The role of fibronectin and tenascin-C networks in tumor angiogenesis and metastasis will be described. We will elaborate on lessons learned about their role in vessel function from the functional ablation or the ectopic expression of both molecules. We will also elaborate on potential mechanisms of how fibronectin and tenascin-C affect cell adhesion and signaling that are relevant to angiogenesis.

Original languageEnglish (US)
Pages (from-to)511-525
Number of pages15
JournalInternational Journal of Developmental Biology
Volume55
Issue number4-5
DOIs
StatePublished - 2011

Fingerprint

Tenascin
Morphogenesis
Growth and Development
Fibronectins
Blood Vessels
Extracellular Matrix
Pathologic Neovascularization
Neoplasms
Angiogenesis Inducing Agents
Extracellular Matrix Proteins
Cell Adhesion
Biological Availability
Neoplasm Metastasis
Proteins

Keywords

  • Fibronectin
  • Matrix assembly
  • Tenascin-C
  • Tumor angiogenesis

ASJC Scopus subject areas

  • Developmental Biology
  • Embryology

Cite this

Fibronectin and tenascin-C : Accomplices in vascular morphogenesis during development and tumor growth. / van Obberghen-Schilling, Ellen; Tucker, Richard P; Saupe, Falk; Gasser, Isabelle; Cseh, Botond; Orend, Gertraud.

In: International Journal of Developmental Biology, Vol. 55, No. 4-5, 2011, p. 511-525.

Research output: Contribution to journalArticle

van Obberghen-Schilling, Ellen ; Tucker, Richard P ; Saupe, Falk ; Gasser, Isabelle ; Cseh, Botond ; Orend, Gertraud. / Fibronectin and tenascin-C : Accomplices in vascular morphogenesis during development and tumor growth. In: International Journal of Developmental Biology. 2011 ; Vol. 55, No. 4-5. pp. 511-525.
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