Fibrinolysis of experimental subretinal haemorrhage without removal using tissue plasminogen activator

Lawrence S Morse, Jeffrey D. Benner, Leonard M Hjelmeland, Maurice B. Landers

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Aims/background - Human recombinant tissue plasminogen activator (rt-PA) fibrinolysis of subretinal haemorrhage with concomitant removal has been shown to reverse the natural history of photoreceptor degeneration in experimental subretinal haemorrhages if evacuated within 7 days. The aim of the study was to determine whether fibrinolysis of subretinal haemorrhage without concomitant removal would offer a simpler approach with similar photoreceptor sparing. Methods - A neodymium YAG laser was used to create experimental subretinal haemorrhages beneath the holangiotic retina of the cat. Tissue plasminogen activator (10 μg/ml) was injected into 4 day old subretinal haemorrhages to evaluate its effect on altering the natural history of retinal degeneration. Light and electron microscopy were used to study the histopathological effect. Results - The injection of rt-PA into large 4 day old subretinal haemorrhages without concomitant removal did not alter the natural history of retinal degeneration. In fact, a second focus of retinal degeneration occurred at a gravity dependent inferior site where the subretinal haemorrhage had migrated. Conclusions - There was no therapeutic benefit from the injection of rt-PA into subretinal haemorrhages without concomitant removal in this cat model.

Original languageEnglish (US)
Pages (from-to)658-662
Number of pages5
JournalBritish Journal of Ophthalmology
Volume80
Issue number7
StatePublished - Jul 1996

ASJC Scopus subject areas

  • Ophthalmology

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