Fiberoptic colonoscopic study of experimental chemical colitis

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Abstract

Acute diffuse chemical colitis was produced in rats with a high degree of reproducibility by the intracolonic administration of 10% acetic acid. The evolution and progression of this colitis was followed by performing serial fiberoptic colonoscopy using a needlescope and biopsy. Hyperemia appeared at 10 hours and ulcerations appeared at 24 hours in acetic acid-treated animals. After 3 days, the ulcers were covered with a yellowish exudate. At 8 weeks there was endoscopic and histologic healing of the lesions. No changes occurred in the saline-treated animals. Concomitant topical application of ε-aminocaproic acid protected against acetic acid-induced injury.

Original languageEnglish (US)
Pages (from-to)38-40
Number of pages3
JournalGastrointestinal Endoscopy
Volume26
Issue number2
StatePublished - 1980
Externally publishedYes

ASJC Scopus subject areas

  • Gastroenterology

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