Fiber size and myosin phenotypes of selected rhesus lower limb muscles after a 14-day spaceflight.

R. R. Roy, H. Zhong, S. C. Bodine, D. J. Pierotti, R. J. Talmadge, G. Barkhoudarian, J. Kim, J. W. Fanton, I. B. Kozlovskaya, V. R. Edgerton

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Abstract

Muscle biopsies were taken from the rhesus (Macaca mulatta) soleus (Sol, a slow ankle extensor), medial gastrocnemius (MG, a fast ankle extensor), tibialis anterior (TA, a fast ankle flexor), and vastus lateralis (VL, a fast knee extensor) muscles in vivarium controls (n=5) before and after either a 14-day spaceflight (Bion 11, n=2) or a 14-day ground-based flight simulation (n=3). Myosin heavy chain (MHC) composition (gel electrophoresis), fiber type distribution (immunohistochemistry), and fiber size were determined. Although there were no significant changes, each muscle showed trends towards adaptation.

Original languageEnglish (US)
JournalJournal of gravitational physiology : a journal of the International Society for Gravitational Physiology
Volume7
Issue number1
StatePublished - 2000

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    Roy, R. R., Zhong, H., Bodine, S. C., Pierotti, D. J., Talmadge, R. J., Barkhoudarian, G., Kim, J., Fanton, J. W., Kozlovskaya, I. B., & Edgerton, V. R. (2000). Fiber size and myosin phenotypes of selected rhesus lower limb muscles after a 14-day spaceflight. Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology, 7(1).