Fetal surgery for myelomeningocele

Shinjiro Hirose, Diana L Farmer, Craig T. Albanese

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Myelomeningocele is a devastating birth defect affecting a significant number of live births worldwide. Prenatal repair of myelomeningocele has been performed in the United States for 5 years with mixed results. The initial intent was to preserve distal neurological function by covering the exposed spinal cord. Although there has been relatively little effect on distal sensorimotor function, prenatal repair serendipitously led to an apparent reduction in hindbrain herniation and a possible decreased need for ventriculoperitoneal shunting. The long-term clinical consequences of these findings are not clear. What is clear, however, is that further study in the form of a prospective, randomized trial is mandatory.

Original languageEnglish (US)
Pages (from-to)215-222
Number of pages8
JournalCurrent Opinion in Obstetrics and Gynecology
Volume13
Issue number2
DOIs
StatePublished - 2001

Fingerprint

Meningomyelocele
Rhombencephalon
Live Birth
Spinal Cord

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Fetal surgery for myelomeningocele. / Hirose, Shinjiro; Farmer, Diana L; Albanese, Craig T.

In: Current Opinion in Obstetrics and Gynecology, Vol. 13, No. 2, 2001, p. 215-222.

Research output: Contribution to journalArticle

@article{e5a46f8f11704e22b50b620d8f1149ea,
title = "Fetal surgery for myelomeningocele",
abstract = "Myelomeningocele is a devastating birth defect affecting a significant number of live births worldwide. Prenatal repair of myelomeningocele has been performed in the United States for 5 years with mixed results. The initial intent was to preserve distal neurological function by covering the exposed spinal cord. Although there has been relatively little effect on distal sensorimotor function, prenatal repair serendipitously led to an apparent reduction in hindbrain herniation and a possible decreased need for ventriculoperitoneal shunting. The long-term clinical consequences of these findings are not clear. What is clear, however, is that further study in the form of a prospective, randomized trial is mandatory.",
author = "Shinjiro Hirose and Farmer, {Diana L} and Albanese, {Craig T.}",
year = "2001",
doi = "10.1097/00001703-200104000-00017",
language = "English (US)",
volume = "13",
pages = "215--222",
journal = "Current Opinion in Obstetrics and Gynecology",
issn = "1040-872X",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Fetal surgery for myelomeningocele

AU - Hirose, Shinjiro

AU - Farmer, Diana L

AU - Albanese, Craig T.

PY - 2001

Y1 - 2001

N2 - Myelomeningocele is a devastating birth defect affecting a significant number of live births worldwide. Prenatal repair of myelomeningocele has been performed in the United States for 5 years with mixed results. The initial intent was to preserve distal neurological function by covering the exposed spinal cord. Although there has been relatively little effect on distal sensorimotor function, prenatal repair serendipitously led to an apparent reduction in hindbrain herniation and a possible decreased need for ventriculoperitoneal shunting. The long-term clinical consequences of these findings are not clear. What is clear, however, is that further study in the form of a prospective, randomized trial is mandatory.

AB - Myelomeningocele is a devastating birth defect affecting a significant number of live births worldwide. Prenatal repair of myelomeningocele has been performed in the United States for 5 years with mixed results. The initial intent was to preserve distal neurological function by covering the exposed spinal cord. Although there has been relatively little effect on distal sensorimotor function, prenatal repair serendipitously led to an apparent reduction in hindbrain herniation and a possible decreased need for ventriculoperitoneal shunting. The long-term clinical consequences of these findings are not clear. What is clear, however, is that further study in the form of a prospective, randomized trial is mandatory.

UR - http://www.scopus.com/inward/record.url?scp=0034912930&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034912930&partnerID=8YFLogxK

U2 - 10.1097/00001703-200104000-00017

DO - 10.1097/00001703-200104000-00017

M3 - Article

VL - 13

SP - 215

EP - 222

JO - Current Opinion in Obstetrics and Gynecology

JF - Current Opinion in Obstetrics and Gynecology

SN - 1040-872X

IS - 2

ER -