Fetal Pathology in an Aborted Holstein Fetus Infected With Bovine Parainfluenza Virus-3 Genotype A

Melissa Macías-Rioseco, Santiago Mirazo, Francisco A Uzal, Martín Fraga, Caroline Silveira, Leticia Maya, Franklin Riet-Correa, Juan Arbiza, Rodney Colina, Mark L Anderson, Federico Giannitti

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Bovine parainfluenza virus-3 (BPIV-3) is a recognized respiratory pathogen of cattle, and it has also been identified in aborted fetuses. However, little is known of this agent as a reproductive pathogen and detailed descriptions of fetal pathology on natural cases are lacking in the scientific literature. This article describes and illustrates lesions in a fetus spontaneously aborted by a first-calving Holstein heifer, naturally infected with BPIV-3 genotype A, broadening the current knowledge on fetal pathology by this virus. Fetal autopsy revealed diffusely reddened, rubbery and unexpanded lungs. Histologically, there was necrotizing bronchiolitis/alveolitis with intraluminal fibrin exudate and syncytial cells in the bronchiolar/alveolar spaces, and non-suppurative peribronchiolitis and perivascular interstitial pneumonia. In the small intestine there was multifocal necrotizing cryptitis and occasional necrotic syncytial enterocytes. Intralesional and extralesional BPIV-3 antigen was detected by immunohistochemistry in the lung and small intestine, and BPIV-3a was identified in fetal tissues by RT-PCR and sequencing.

Original languageEnglish (US)
JournalVeterinary Pathology
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Bovine parainfluenza virus 3
Aborted Fetus
fetus
Holstein
Genotype
Pathology
Small Intestine
small intestine
genotype
lungs
alveolitis
Literature
Lung
Bronchiolitis
fibrin
Enterocytes
pathogens
Interstitial Lung Diseases
enterocytes
Exudates and Transudates

Keywords

  • abortion
  • bovine parainfluenza virus-3
  • fetus
  • immunohistochemistry
  • Paramyxoviridae
  • reproductive pathology
  • Respirovirus
  • RT-PCR

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Fetal Pathology in an Aborted Holstein Fetus Infected With Bovine Parainfluenza Virus-3 Genotype A. / Macías-Rioseco, Melissa; Mirazo, Santiago; Uzal, Francisco A; Fraga, Martín; Silveira, Caroline; Maya, Leticia; Riet-Correa, Franklin; Arbiza, Juan; Colina, Rodney; Anderson, Mark L; Giannitti, Federico.

In: Veterinary Pathology, 01.01.2018.

Research output: Contribution to journalArticle

Macías-Rioseco, M, Mirazo, S, Uzal, FA, Fraga, M, Silveira, C, Maya, L, Riet-Correa, F, Arbiza, J, Colina, R, Anderson, ML & Giannitti, F 2018, 'Fetal Pathology in an Aborted Holstein Fetus Infected With Bovine Parainfluenza Virus-3 Genotype A', Veterinary Pathology. https://doi.org/10.1177/0300985818798117
Macías-Rioseco, Melissa ; Mirazo, Santiago ; Uzal, Francisco A ; Fraga, Martín ; Silveira, Caroline ; Maya, Leticia ; Riet-Correa, Franklin ; Arbiza, Juan ; Colina, Rodney ; Anderson, Mark L ; Giannitti, Federico. / Fetal Pathology in an Aborted Holstein Fetus Infected With Bovine Parainfluenza Virus-3 Genotype A. In: Veterinary Pathology. 2018.
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