Fetal Pathology in an Aborted Holstein Fetus Infected With Bovine Parainfluenza Virus-3 Genotype A

Melissa Macías-Rioseco, Santiago Mirazo, Francisco A Uzal, Martín Fraga, Caroline Silveira, Leticia Maya, Franklin Riet-Correa, Juan Arbiza, Rodney Colina, Mark L Anderson, Federico Giannitti

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Bovine parainfluenza virus-3 (BPIV-3) is a recognized respiratory pathogen of cattle, and it has also been identified in aborted fetuses. However, little is known of this agent as a reproductive pathogen and detailed descriptions of fetal pathology on natural cases are lacking in the scientific literature. This article describes and illustrates lesions in a fetus spontaneously aborted by a first-calving Holstein heifer, naturally infected with BPIV-3 genotype A, broadening the current knowledge on fetal pathology by this virus. Fetal autopsy revealed diffusely reddened, rubbery and unexpanded lungs. Histologically, there was necrotizing bronchiolitis/alveolitis with intraluminal fibrin exudate and syncytial cells in the bronchiolar/alveolar spaces, and non-suppurative peribronchiolitis and perivascular interstitial pneumonia. In the small intestine there was multifocal necrotizing cryptitis and occasional necrotic syncytial enterocytes. Intralesional and extralesional BPIV-3 antigen was detected by immunohistochemistry in the lung and small intestine, and BPIV-3a was identified in fetal tissues by RT-PCR and sequencing.

Original languageEnglish (US)
JournalVeterinary Pathology
DOIs
StateAccepted/In press - Jan 1 2018

Keywords

  • abortion
  • bovine parainfluenza virus-3
  • fetus
  • immunohistochemistry
  • Paramyxoviridae
  • reproductive pathology
  • Respirovirus
  • RT-PCR

ASJC Scopus subject areas

  • veterinary(all)

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    Macías-Rioseco, M., Mirazo, S., Uzal, F. A., Fraga, M., Silveira, C., Maya, L., Riet-Correa, F., Arbiza, J., Colina, R., Anderson, M. L., & Giannitti, F. (Accepted/In press). Fetal Pathology in an Aborted Holstein Fetus Infected With Bovine Parainfluenza Virus-3 Genotype A. Veterinary Pathology. https://doi.org/10.1177/0300985818798117