Abstract
Bovine parainfluenza virus-3 (BPIV-3) is a recognized respiratory pathogen of cattle, and it has also been identified in aborted fetuses. However, little is known of this agent as a reproductive pathogen and detailed descriptions of fetal pathology on natural cases are lacking in the scientific literature. This article describes and illustrates lesions in a fetus spontaneously aborted by a first-calving Holstein heifer, naturally infected with BPIV-3 genotype A, broadening the current knowledge on fetal pathology by this virus. Fetal autopsy revealed diffusely reddened, rubbery and unexpanded lungs. Histologically, there was necrotizing bronchiolitis/alveolitis with intraluminal fibrin exudate and syncytial cells in the bronchiolar/alveolar spaces, and non-suppurative peribronchiolitis and perivascular interstitial pneumonia. In the small intestine there was multifocal necrotizing cryptitis and occasional necrotic syncytial enterocytes. Intralesional and extralesional BPIV-3 antigen was detected by immunohistochemistry in the lung and small intestine, and BPIV-3a was identified in fetal tissues by RT-PCR and sequencing.
| Original language | English (US) |
|---|---|
| Journal | Veterinary Pathology |
| DOIs | |
| State | Accepted/In press - Jan 1 2018 |
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Keywords
- abortion
- bovine parainfluenza virus-3
- fetus
- immunohistochemistry
- Paramyxoviridae
- reproductive pathology
- Respirovirus
- RT-PCR
ASJC Scopus subject areas
- veterinary(all)
Cite this
Fetal Pathology in an Aborted Holstein Fetus Infected With Bovine Parainfluenza Virus-3 Genotype A. / Macías-Rioseco, Melissa; Mirazo, Santiago; Uzal, Francisco A; Fraga, Martín; Silveira, Caroline; Maya, Leticia; Riet-Correa, Franklin; Arbiza, Juan; Colina, Rodney; Anderson, Mark L; Giannitti, Federico.
In: Veterinary Pathology, 01.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fetal Pathology in an Aborted Holstein Fetus Infected With Bovine Parainfluenza Virus-3 Genotype A
AU - Macías-Rioseco, Melissa
AU - Mirazo, Santiago
AU - Uzal, Francisco A
AU - Fraga, Martín
AU - Silveira, Caroline
AU - Maya, Leticia
AU - Riet-Correa, Franklin
AU - Arbiza, Juan
AU - Colina, Rodney
AU - Anderson, Mark L
AU - Giannitti, Federico
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Bovine parainfluenza virus-3 (BPIV-3) is a recognized respiratory pathogen of cattle, and it has also been identified in aborted fetuses. However, little is known of this agent as a reproductive pathogen and detailed descriptions of fetal pathology on natural cases are lacking in the scientific literature. This article describes and illustrates lesions in a fetus spontaneously aborted by a first-calving Holstein heifer, naturally infected with BPIV-3 genotype A, broadening the current knowledge on fetal pathology by this virus. Fetal autopsy revealed diffusely reddened, rubbery and unexpanded lungs. Histologically, there was necrotizing bronchiolitis/alveolitis with intraluminal fibrin exudate and syncytial cells in the bronchiolar/alveolar spaces, and non-suppurative peribronchiolitis and perivascular interstitial pneumonia. In the small intestine there was multifocal necrotizing cryptitis and occasional necrotic syncytial enterocytes. Intralesional and extralesional BPIV-3 antigen was detected by immunohistochemistry in the lung and small intestine, and BPIV-3a was identified in fetal tissues by RT-PCR and sequencing.
AB - Bovine parainfluenza virus-3 (BPIV-3) is a recognized respiratory pathogen of cattle, and it has also been identified in aborted fetuses. However, little is known of this agent as a reproductive pathogen and detailed descriptions of fetal pathology on natural cases are lacking in the scientific literature. This article describes and illustrates lesions in a fetus spontaneously aborted by a first-calving Holstein heifer, naturally infected with BPIV-3 genotype A, broadening the current knowledge on fetal pathology by this virus. Fetal autopsy revealed diffusely reddened, rubbery and unexpanded lungs. Histologically, there was necrotizing bronchiolitis/alveolitis with intraluminal fibrin exudate and syncytial cells in the bronchiolar/alveolar spaces, and non-suppurative peribronchiolitis and perivascular interstitial pneumonia. In the small intestine there was multifocal necrotizing cryptitis and occasional necrotic syncytial enterocytes. Intralesional and extralesional BPIV-3 antigen was detected by immunohistochemistry in the lung and small intestine, and BPIV-3a was identified in fetal tissues by RT-PCR and sequencing.
KW - abortion
KW - bovine parainfluenza virus-3
KW - fetus
KW - immunohistochemistry
KW - Paramyxoviridae
KW - reproductive pathology
KW - Respirovirus
KW - RT-PCR
UR - http://www.scopus.com/inward/record.url?scp=85060257261&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85060257261&partnerID=8YFLogxK
U2 - 10.1177/0300985818798117
DO - 10.1177/0300985818798117
M3 - Article
C2 - 30244663
AN - SCOPUS:85060257261
JO - Veterinary Pathology
JF - Veterinary Pathology
SN - 0300-9858
ER -