TY - JOUR
T1 - Fetal Pathology in an Aborted Holstein Fetus Infected With Bovine Parainfluenza Virus-3 Genotype A
AU - Macías-Rioseco, Melissa
AU - Mirazo, Santiago
AU - Uzal, Francisco A.
AU - Fraga, Martín
AU - Silveira, Caroline
AU - Maya, Leticia
AU - Riet-Correa, Franklin
AU - Arbiza, Juan
AU - Colina, Rodney
AU - Anderson, Mark L.
AU - Giannitti, Federico
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Bovine parainfluenza virus-3 (BPIV-3) is a recognized respiratory pathogen of cattle, and it has also been identified in aborted fetuses. However, little is known of this agent as a reproductive pathogen and detailed descriptions of fetal pathology on natural cases are lacking in the scientific literature. This article describes and illustrates lesions in a fetus spontaneously aborted by a first-calving Holstein heifer, naturally infected with BPIV-3 genotype A, broadening the current knowledge on fetal pathology by this virus. Fetal autopsy revealed diffusely reddened, rubbery and unexpanded lungs. Histologically, there was necrotizing bronchiolitis/alveolitis with intraluminal fibrin exudate and syncytial cells in the bronchiolar/alveolar spaces, and non-suppurative peribronchiolitis and perivascular interstitial pneumonia. In the small intestine there was multifocal necrotizing cryptitis and occasional necrotic syncytial enterocytes. Intralesional and extralesional BPIV-3 antigen was detected by immunohistochemistry in the lung and small intestine, and BPIV-3a was identified in fetal tissues by RT-PCR and sequencing.
AB - Bovine parainfluenza virus-3 (BPIV-3) is a recognized respiratory pathogen of cattle, and it has also been identified in aborted fetuses. However, little is known of this agent as a reproductive pathogen and detailed descriptions of fetal pathology on natural cases are lacking in the scientific literature. This article describes and illustrates lesions in a fetus spontaneously aborted by a first-calving Holstein heifer, naturally infected with BPIV-3 genotype A, broadening the current knowledge on fetal pathology by this virus. Fetal autopsy revealed diffusely reddened, rubbery and unexpanded lungs. Histologically, there was necrotizing bronchiolitis/alveolitis with intraluminal fibrin exudate and syncytial cells in the bronchiolar/alveolar spaces, and non-suppurative peribronchiolitis and perivascular interstitial pneumonia. In the small intestine there was multifocal necrotizing cryptitis and occasional necrotic syncytial enterocytes. Intralesional and extralesional BPIV-3 antigen was detected by immunohistochemistry in the lung and small intestine, and BPIV-3a was identified in fetal tissues by RT-PCR and sequencing.
KW - abortion
KW - bovine parainfluenza virus-3
KW - fetus
KW - immunohistochemistry
KW - Paramyxoviridae
KW - reproductive pathology
KW - Respirovirus
KW - RT-PCR
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U2 - 10.1177/0300985818798117
DO - 10.1177/0300985818798117
M3 - Article
C2 - 30244663
AN - SCOPUS:85060257261
JO - Pathologia veterinaria
JF - Pathologia veterinaria
SN - 0300-9858
ER -