Fermenting next generation glycosylated therapeutics

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Mutants of glycosyltransferases and related sugar nucleotide biosynthetic enzymes have been essential for in vitro glycorandomization to create libraries of novel glycosylated natural products and derivatives. These diverse glycorandomized compounds can now be produced in vivo economically by fermenting engineered Escherichia coli cells that express enzyme mutants.

Original languageEnglish (US)
Pages (from-to)14-17
Number of pages4
JournalACS Chemical Biology
Issue number1
StatePublished - Jan 21 2011

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine


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