Fermenting next generation glycosylated therapeutics

Xi Chen

doi:10.1021/cb100375y

Fermenting next generation glycosylated therapeutics

Xi Chen

Chemistry

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Mutants of glycosyltransferases and related sugar nucleotide biosynthetic enzymes have been essential for in vitro glycorandomization to create libraries of novel glycosylated natural products and derivatives. These diverse glycorandomized compounds can now be produced in vivo economically by fermenting engineered Escherichia coli cells that express enzyme mutants.

Original language	English (US)
Pages (from-to)	14-17
Number of pages	4
Journal	ACS Chemical Biology
Volume	6
Issue number	1
DOIs	https://doi.org/10.1021/cb100375y
State	Published - Jan 21 2011

ASJC Scopus subject areas

Biochemistry
Molecular Medicine

Access to Document

10.1021/cb100375y

Fingerprint Dive into the research topics of 'Fermenting next generation glycosylated therapeutics'. Together they form a unique fingerprint.

Cite this

@article{37260b1096094488b1533278c02bc9b7,

title = "Fermenting next generation glycosylated therapeutics",

abstract = "Mutants of glycosyltransferases and related sugar nucleotide biosynthetic enzymes have been essential for in vitro glycorandomization to create libraries of novel glycosylated natural products and derivatives. These diverse glycorandomized compounds can now be produced in vivo economically by fermenting engineered Escherichia coli cells that express enzyme mutants.",

author = "Xi Chen",

year = "2011",

month = jan,

day = "21",

doi = "10.1021/cb100375y",

language = "English (US)",

volume = "6",

pages = "14--17",

journal = "ACS Chemical Biology",

issn = "1554-8929",

publisher = "American Chemical Society",

number = "1",

}

TY - JOUR

T1 - Fermenting next generation glycosylated therapeutics

AU - Chen, Xi

PY - 2011/1/21

Y1 - 2011/1/21

N2 - Mutants of glycosyltransferases and related sugar nucleotide biosynthetic enzymes have been essential for in vitro glycorandomization to create libraries of novel glycosylated natural products and derivatives. These diverse glycorandomized compounds can now be produced in vivo economically by fermenting engineered Escherichia coli cells that express enzyme mutants.

AB - Mutants of glycosyltransferases and related sugar nucleotide biosynthetic enzymes have been essential for in vitro glycorandomization to create libraries of novel glycosylated natural products and derivatives. These diverse glycorandomized compounds can now be produced in vivo economically by fermenting engineered Escherichia coli cells that express enzyme mutants.

UR - http://www.scopus.com/inward/record.url?scp=79251498607&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79251498607&partnerID=8YFLogxK

U2 - 10.1021/cb100375y

DO - 10.1021/cb100375y

M3 - Article

C2 - 21250649

AN - SCOPUS:79251498607

VL - 6

SP - 14

EP - 17

JO - ACS Chemical Biology

JF - ACS Chemical Biology

SN - 1554-8929

IS - 1

ER -

Fermenting next generation glycosylated therapeutics

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this