Fermenting next generation glycosylated therapeutics

Xi Chen

Research output: Contribution to journal › Article

16 Citations (Scopus)

Abstract

Mutants of glycosyltransferases and related sugar nucleotide biosynthetic enzymes have been essential for in vitro glycorandomization to create libraries of novel glycosylated natural products and derivatives. These diverse glycorandomized compounds can now be produced in vivo economically by fermenting engineered Escherichia coli cells that express enzyme mutants.

Original languageEnglish (US)
Pages (from-to)14-17
Number of pages4
JournalACS Chemical Biology
Volume6
Issue number1
DOIs
StatePublished - Jan 21 2011

Fingerprint

Glycosyltransferases
Enzymes
Biological Products
Sugars
Escherichia coli
Libraries
Nucleotides
Derivatives
Therapeutics
In Vitro Techniques

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine

Cite this

Fermenting next generation glycosylated therapeutics. / Chen, Xi.

In: ACS Chemical Biology, Vol. 6, No. 1, 21.01.2011, p. 14-17.

Research output: Contribution to journal › Article

Chen, X 2011, 'Fermenting next generation glycosylated therapeutics', ACS Chemical Biology, vol. 6, no. 1, pp. 14-17. https://doi.org/10.1021/cb100375y
Chen X. Fermenting next generation glycosylated therapeutics. ACS Chemical Biology. 2011 Jan 21;6(1):14-17. https://doi.org/10.1021/cb100375y
Chen, Xi. / Fermenting next generation glycosylated therapeutics. In: ACS Chemical Biology. 2011 ; Vol. 6, No. 1. pp. 14-17.
@article{37260b1096094488b1533278c02bc9b7,
title = "Fermenting next generation glycosylated therapeutics",
abstract = "Mutants of glycosyltransferases and related sugar nucleotide biosynthetic enzymes have been essential for in vitro glycorandomization to create libraries of novel glycosylated natural products and derivatives. These diverse glycorandomized compounds can now be produced in vivo economically by fermenting engineered Escherichia coli cells that express enzyme mutants.",
author = "Xi Chen",
year = "2011",
month = "1",
day = "21",
doi = "10.1021/cb100375y",
language = "English (US)",
volume = "6",
pages = "14--17",
journal = "ACS Chemical Biology",
issn = "1554-8929",
publisher = "American Chemical Society",
number = "1",

}

TY - JOUR

T1 - Fermenting next generation glycosylated therapeutics

AU - Chen, Xi

PY - 2011/1/21

Y1 - 2011/1/21

N2 - Mutants of glycosyltransferases and related sugar nucleotide biosynthetic enzymes have been essential for in vitro glycorandomization to create libraries of novel glycosylated natural products and derivatives. These diverse glycorandomized compounds can now be produced in vivo economically by fermenting engineered Escherichia coli cells that express enzyme mutants.

AB - Mutants of glycosyltransferases and related sugar nucleotide biosynthetic enzymes have been essential for in vitro glycorandomization to create libraries of novel glycosylated natural products and derivatives. These diverse glycorandomized compounds can now be produced in vivo economically by fermenting engineered Escherichia coli cells that express enzyme mutants.

UR - http://www.scopus.com/inward/record.url?scp=79251498607&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79251498607&partnerID=8YFLogxK

U2 - 10.1021/cb100375y

DO - 10.1021/cb100375y

M3 - Article

C2 - 21250649

AN - SCOPUS:79251498607

VL - 6

SP - 14

EP - 17

JO - ACS Chemical Biology

JF - ACS Chemical Biology

SN - 1554-8929

IS - 1

ER -

Access to Document