Fermenting next generation glycosylated therapeutics

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Mutants of glycosyltransferases and related sugar nucleotide biosynthetic enzymes have been essential for in vitro glycorandomization to create libraries of novel glycosylated natural products and derivatives. These diverse glycorandomized compounds can now be produced in vivo economically by fermenting engineered Escherichia coli cells that express enzyme mutants.

Original languageEnglish (US)
Pages (from-to)14-17
Number of pages4
JournalACS Chemical Biology
Volume6
Issue number1
DOIs
StatePublished - Jan 21 2011

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Glycosyltransferases
Enzymes
Biological Products
Sugars
Escherichia coli
Libraries
Nucleotides
Derivatives
Therapeutics
In Vitro Techniques

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine

Cite this

Fermenting next generation glycosylated therapeutics. / Chen, Xi.

In: ACS Chemical Biology, Vol. 6, No. 1, 21.01.2011, p. 14-17.

Research output: Contribution to journalArticle

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