Abstract
Mutants of glycosyltransferases and related sugar nucleotide biosynthetic enzymes have been essential for in vitro glycorandomization to create libraries of novel glycosylated natural products and derivatives. These diverse glycorandomized compounds can now be produced in vivo economically by fermenting engineered Escherichia coli cells that express enzyme mutants.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 14-17 |
| Number of pages | 4 |
| Journal | ACS Chemical Biology |
| Volume | 6 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 21 2011 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine