Fermenting next generation glycosylated therapeutics

Xi Chen

doi:10.1021/cb100375y

Fermenting next generation glycosylated therapeutics

Xi Chen

Chemistry

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Mutants of glycosyltransferases and related sugar nucleotide biosynthetic enzymes have been essential for in vitro glycorandomization to create libraries of novel glycosylated natural products and derivatives. These diverse glycorandomized compounds can now be produced in vivo economically by fermenting engineered Escherichia coli cells that express enzyme mutants.

Original language	English (US)
Pages (from-to)	14-17
Number of pages	4
Journal	ACS Chemical Biology
Volume	6
Issue number	1
DOIs	https://doi.org/10.1021/cb100375y
State	Published - Jan 21 2011

ASJC Scopus subject areas

Biochemistry
Molecular Medicine

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10.1021/cb100375y

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title = "Fermenting next generation glycosylated therapeutics",

abstract = "Mutants of glycosyltransferases and related sugar nucleotide biosynthetic enzymes have been essential for in vitro glycorandomization to create libraries of novel glycosylated natural products and derivatives. These diverse glycorandomized compounds can now be produced in vivo economically by fermenting engineered Escherichia coli cells that express enzyme mutants.",

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