Femtosecond diffractive imaging with a soft-X-ray free-electron laser

Henry N. Chapman, Anton Barty, Michael J. Bogan, Sébastien Boutet, Matthias Frank, Stefan P. Hau-Riege, Stefano Marchesini, Bruce W. Woods, Saša Bajt, W. Henry Benner, Richard A. London, Elke Plönjes, Marion Kuhlmann, Rolf Treusch, Stefan Düsterer, Thomas Tschentscher, Jochen R. Schneider, Eberhard Spiller, Thomas Möller, Christoph Bostedt & 14 others Matthias Hoener, David A. Shapiro, Keith O. Hodgson, David Van Der Spoel, Florian Burmeister, Magnus Bergh, Carl Caleman, Gösta Huldt, M. Marvin Seibert, Filipe R.N.C. Maia, Richard W. Lee, Abraham Szöke, Nicusor Timneanu, Janos Hajdu

Research output: Contribution to journalArticle

714 Citations (Scopus)

Abstract

Theory predicts that, with an ultrashort and extremely bright coherent X-ray pulse, a single diffraction pattern may be recorded from a large macromolecule, a virus or a cell before the sample explodes and turns into a plasma. Here we report the first experimental demonstration of this principle using the FLASH soft-X-ray free-electron laser. An intense 25 fs, 4×1013 W cm-2 pulse, containing 1012 photons at 32 nm wavelength, produced a coherent diffraction pattern from a nanostructured non-periodic object, before destroying it at 60,000 K. A novel X-ray camera assured single-photon detection sensitivity by filtering out parasitic scattering and plasma radiation. The reconstructed image, obtained directly from the coherent pattern by phase retrieval through oversampling, shows no measurable damage, and is reconstructed at the diffraction-limited resolution. A three-dimensional data set may be assembled from such images when copies of a reproducible sample are exposed to the beam one by one.

Original languageEnglish (US)
Pages (from-to)839-843
Number of pages5
JournalNature Physics
Volume2
Issue number12
DOIs
StatePublished - Dec 1 2006
Externally publishedYes

Fingerprint

free electron lasers
diffraction patterns
plasma radiation
x rays
photons
viruses
pulses
macromolecules
retrieval
cameras
damage
radiation
cells
scattering
diffraction
wavelengths

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Chapman, H. N., Barty, A., Bogan, M. J., Boutet, S., Frank, M., Hau-Riege, S. P., ... Hajdu, J. (2006). Femtosecond diffractive imaging with a soft-X-ray free-electron laser. Nature Physics, 2(12), 839-843. https://doi.org/10.1038/nphys461

Femtosecond diffractive imaging with a soft-X-ray free-electron laser. / Chapman, Henry N.; Barty, Anton; Bogan, Michael J.; Boutet, Sébastien; Frank, Matthias; Hau-Riege, Stefan P.; Marchesini, Stefano; Woods, Bruce W.; Bajt, Saša; Benner, W. Henry; London, Richard A.; Plönjes, Elke; Kuhlmann, Marion; Treusch, Rolf; Düsterer, Stefan; Tschentscher, Thomas; Schneider, Jochen R.; Spiller, Eberhard; Möller, Thomas; Bostedt, Christoph; Hoener, Matthias; Shapiro, David A.; Hodgson, Keith O.; Van Der Spoel, David; Burmeister, Florian; Bergh, Magnus; Caleman, Carl; Huldt, Gösta; Seibert, M. Marvin; Maia, Filipe R.N.C.; Lee, Richard W.; Szöke, Abraham; Timneanu, Nicusor; Hajdu, Janos.

In: Nature Physics, Vol. 2, No. 12, 01.12.2006, p. 839-843.

Research output: Contribution to journalArticle

Chapman, HN, Barty, A, Bogan, MJ, Boutet, S, Frank, M, Hau-Riege, SP, Marchesini, S, Woods, BW, Bajt, S, Benner, WH, London, RA, Plönjes, E, Kuhlmann, M, Treusch, R, Düsterer, S, Tschentscher, T, Schneider, JR, Spiller, E, Möller, T, Bostedt, C, Hoener, M, Shapiro, DA, Hodgson, KO, Van Der Spoel, D, Burmeister, F, Bergh, M, Caleman, C, Huldt, G, Seibert, MM, Maia, FRNC, Lee, RW, Szöke, A, Timneanu, N & Hajdu, J 2006, 'Femtosecond diffractive imaging with a soft-X-ray free-electron laser', Nature Physics, vol. 2, no. 12, pp. 839-843. https://doi.org/10.1038/nphys461
Chapman HN, Barty A, Bogan MJ, Boutet S, Frank M, Hau-Riege SP et al. Femtosecond diffractive imaging with a soft-X-ray free-electron laser. Nature Physics. 2006 Dec 1;2(12):839-843. https://doi.org/10.1038/nphys461
Chapman, Henry N. ; Barty, Anton ; Bogan, Michael J. ; Boutet, Sébastien ; Frank, Matthias ; Hau-Riege, Stefan P. ; Marchesini, Stefano ; Woods, Bruce W. ; Bajt, Saša ; Benner, W. Henry ; London, Richard A. ; Plönjes, Elke ; Kuhlmann, Marion ; Treusch, Rolf ; Düsterer, Stefan ; Tschentscher, Thomas ; Schneider, Jochen R. ; Spiller, Eberhard ; Möller, Thomas ; Bostedt, Christoph ; Hoener, Matthias ; Shapiro, David A. ; Hodgson, Keith O. ; Van Der Spoel, David ; Burmeister, Florian ; Bergh, Magnus ; Caleman, Carl ; Huldt, Gösta ; Seibert, M. Marvin ; Maia, Filipe R.N.C. ; Lee, Richard W. ; Szöke, Abraham ; Timneanu, Nicusor ; Hajdu, Janos. / Femtosecond diffractive imaging with a soft-X-ray free-electron laser. In: Nature Physics. 2006 ; Vol. 2, No. 12. pp. 839-843.
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