Femoropopliteal in-stent restenosis: Current treatment strategies

Gagan Singh, E. J. Armstrong, J. R. Laird

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Nitinol self-expanding stents are increasingly used to treat symptomatic peripheral arterial disease. Despite reduction in procedural complications and rates of stent fracture, femoropopliteal in-stent restenosis (FP-ISR) remains a common and important clinical problem. Due to heterogenous patient and angiographic characteristics, treatment of FP-ISR continues to evolve. Multiple modalities have been evaluated including standard balloon angioplasty, cutting or scoring balloon angioplasty, repeat stenting (nitinol stent vs. stent-graft vs. drug eluting stent), excisional or laser atherectomy, drug coated balloon angioplasty, and atherectomy followed by drug coated balloon angioplasty. This review highlights the clinical evidence for the currently available modalities in the treatment of FP-ISR. Future studies should utilize uniform classification schemes and assess similar outcomes to help determine the optimal approach for endovascular treatment of FP-ISR.

Original languageEnglish (US)
Pages (from-to)325-333
Number of pages9
JournalJournal of Cardiovascular Surgery
Issue number3
StatePublished - 2014


  • Endovascular procedures
  • Ischemia
  • Sents

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery


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