Femoropopliteal artery stent thrombosis: Report from the excellence in peripheral artery disease registry

Subhash Banerjee, Karan Sarode, Atif Mohammad, Osvaldo Gigliotti, Mirza S. Baig, Shirling Tsai, Nicolas W. Shammas, Anand Prasad, Mazen Abu-Fadel, Andrew Klein, Ehrin J. Armstrong, Haekyung Jeon-Slaughter, Emmanouil S. Brilakis, Deepak L. Bhatt

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background - There are limited data on femoropopliteal artery stent thrombosis (ST), which is a serious adverse outcome of peripheral artery interventions. Methods and Results - Index procedures resulting in femoropopliteal ST were compared with stent procedures without subsequent ST in the Excellence in Peripheral Artery Disease registry. The study data had a total of 724 cases of stent procedures and 604 unique patients. Femoropopliteal ST occurred in 26 of 604 patients (4.3%) over a median follow-up of 6 months post procedure. ST was more likely to occur in men (96.3% versus 82.2%; P=0.026) and to have an initial intervention for chronic total occlusions (88.5% versus 64.0%; P=0.01). There was no significant difference in ST between drug-coated and bare-metal stents (4.4% versus 3.4%; P=0.55), but the rate of ST was significantly higher with self-expanding covered stent grafts compared with bare-metal stents (10.6% versus 3.4%; P=0.02). ST was significantly associated with an increased risk of 12-month major adverse limb events (hazard ratio, 4.99; 95% confidence interval, 2.31-10.77; P<0.001) compared with no ST. On multivariate analysis, treatment of chronic total occlusion lesions (odds ratio, 3.46; 95% confidence interval, 0.98-12.20; P=0.05) and in-stent restenosis lesions (odds ratio, 5.30; 95% confidence interval, 1.83-15.32; P=0.002) were independently associated with an increased risk of ST. Conclusions - In a multicenter peripheral interventional registry, femoropopliteal ST occurred in 4.3% of patients who underwent stent procedures, and it was associated with treatment of chronic total occlusions and in-stent restenosis lesions, and had higher 12-month major adverse limb events.

Original languageEnglish (US)
Article numbere002730
JournalCirculation: Cardiovascular Interventions
Volume9
Issue number2
DOIs
StatePublished - Feb 1 2016
Externally publishedYes

Fingerprint

Peripheral Arterial Disease
Stents
Registries
Thrombosis
Arteries
Confidence Intervals
Extremities
Metals
Odds Ratio

Keywords

  • Confidence intervals
  • Odds ratio
  • Peripheral artery disease
  • Stent
  • Thrombosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Femoropopliteal artery stent thrombosis : Report from the excellence in peripheral artery disease registry. / Banerjee, Subhash; Sarode, Karan; Mohammad, Atif; Gigliotti, Osvaldo; Baig, Mirza S.; Tsai, Shirling; Shammas, Nicolas W.; Prasad, Anand; Abu-Fadel, Mazen; Klein, Andrew; Armstrong, Ehrin J.; Jeon-Slaughter, Haekyung; Brilakis, Emmanouil S.; Bhatt, Deepak L.

In: Circulation: Cardiovascular Interventions, Vol. 9, No. 2, e002730, 01.02.2016.

Research output: Contribution to journalArticle

Banerjee, S, Sarode, K, Mohammad, A, Gigliotti, O, Baig, MS, Tsai, S, Shammas, NW, Prasad, A, Abu-Fadel, M, Klein, A, Armstrong, EJ, Jeon-Slaughter, H, Brilakis, ES & Bhatt, DL 2016, 'Femoropopliteal artery stent thrombosis: Report from the excellence in peripheral artery disease registry', Circulation: Cardiovascular Interventions, vol. 9, no. 2, e002730. https://doi.org/10.1161/CIRCINTERVENTIONS.115.002730
Banerjee, Subhash ; Sarode, Karan ; Mohammad, Atif ; Gigliotti, Osvaldo ; Baig, Mirza S. ; Tsai, Shirling ; Shammas, Nicolas W. ; Prasad, Anand ; Abu-Fadel, Mazen ; Klein, Andrew ; Armstrong, Ehrin J. ; Jeon-Slaughter, Haekyung ; Brilakis, Emmanouil S. ; Bhatt, Deepak L. / Femoropopliteal artery stent thrombosis : Report from the excellence in peripheral artery disease registry. In: Circulation: Cardiovascular Interventions. 2016 ; Vol. 9, No. 2.
@article{be6ccfc2e48e49629137fadcb2c48987,
title = "Femoropopliteal artery stent thrombosis: Report from the excellence in peripheral artery disease registry",
abstract = "Background - There are limited data on femoropopliteal artery stent thrombosis (ST), which is a serious adverse outcome of peripheral artery interventions. Methods and Results - Index procedures resulting in femoropopliteal ST were compared with stent procedures without subsequent ST in the Excellence in Peripheral Artery Disease registry. The study data had a total of 724 cases of stent procedures and 604 unique patients. Femoropopliteal ST occurred in 26 of 604 patients (4.3{\%}) over a median follow-up of 6 months post procedure. ST was more likely to occur in men (96.3{\%} versus 82.2{\%}; P=0.026) and to have an initial intervention for chronic total occlusions (88.5{\%} versus 64.0{\%}; P=0.01). There was no significant difference in ST between drug-coated and bare-metal stents (4.4{\%} versus 3.4{\%}; P=0.55), but the rate of ST was significantly higher with self-expanding covered stent grafts compared with bare-metal stents (10.6{\%} versus 3.4{\%}; P=0.02). ST was significantly associated with an increased risk of 12-month major adverse limb events (hazard ratio, 4.99; 95{\%} confidence interval, 2.31-10.77; P<0.001) compared with no ST. On multivariate analysis, treatment of chronic total occlusion lesions (odds ratio, 3.46; 95{\%} confidence interval, 0.98-12.20; P=0.05) and in-stent restenosis lesions (odds ratio, 5.30; 95{\%} confidence interval, 1.83-15.32; P=0.002) were independently associated with an increased risk of ST. Conclusions - In a multicenter peripheral interventional registry, femoropopliteal ST occurred in 4.3{\%} of patients who underwent stent procedures, and it was associated with treatment of chronic total occlusions and in-stent restenosis lesions, and had higher 12-month major adverse limb events.",
keywords = "Confidence intervals, Odds ratio, Peripheral artery disease, Stent, Thrombosis",
author = "Subhash Banerjee and Karan Sarode and Atif Mohammad and Osvaldo Gigliotti and Baig, {Mirza S.} and Shirling Tsai and Shammas, {Nicolas W.} and Anand Prasad and Mazen Abu-Fadel and Andrew Klein and Armstrong, {Ehrin J.} and Haekyung Jeon-Slaughter and Brilakis, {Emmanouil S.} and Bhatt, {Deepak L.}",
year = "2016",
month = "2",
day = "1",
doi = "10.1161/CIRCINTERVENTIONS.115.002730",
language = "English (US)",
volume = "9",
journal = "Circulation: Cardiovascular Interventions",
issn = "1941-7640",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Femoropopliteal artery stent thrombosis

T2 - Report from the excellence in peripheral artery disease registry

AU - Banerjee, Subhash

AU - Sarode, Karan

AU - Mohammad, Atif

AU - Gigliotti, Osvaldo

AU - Baig, Mirza S.

AU - Tsai, Shirling

AU - Shammas, Nicolas W.

AU - Prasad, Anand

AU - Abu-Fadel, Mazen

AU - Klein, Andrew

AU - Armstrong, Ehrin J.

AU - Jeon-Slaughter, Haekyung

AU - Brilakis, Emmanouil S.

AU - Bhatt, Deepak L.

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Background - There are limited data on femoropopliteal artery stent thrombosis (ST), which is a serious adverse outcome of peripheral artery interventions. Methods and Results - Index procedures resulting in femoropopliteal ST were compared with stent procedures without subsequent ST in the Excellence in Peripheral Artery Disease registry. The study data had a total of 724 cases of stent procedures and 604 unique patients. Femoropopliteal ST occurred in 26 of 604 patients (4.3%) over a median follow-up of 6 months post procedure. ST was more likely to occur in men (96.3% versus 82.2%; P=0.026) and to have an initial intervention for chronic total occlusions (88.5% versus 64.0%; P=0.01). There was no significant difference in ST between drug-coated and bare-metal stents (4.4% versus 3.4%; P=0.55), but the rate of ST was significantly higher with self-expanding covered stent grafts compared with bare-metal stents (10.6% versus 3.4%; P=0.02). ST was significantly associated with an increased risk of 12-month major adverse limb events (hazard ratio, 4.99; 95% confidence interval, 2.31-10.77; P<0.001) compared with no ST. On multivariate analysis, treatment of chronic total occlusion lesions (odds ratio, 3.46; 95% confidence interval, 0.98-12.20; P=0.05) and in-stent restenosis lesions (odds ratio, 5.30; 95% confidence interval, 1.83-15.32; P=0.002) were independently associated with an increased risk of ST. Conclusions - In a multicenter peripheral interventional registry, femoropopliteal ST occurred in 4.3% of patients who underwent stent procedures, and it was associated with treatment of chronic total occlusions and in-stent restenosis lesions, and had higher 12-month major adverse limb events.

AB - Background - There are limited data on femoropopliteal artery stent thrombosis (ST), which is a serious adverse outcome of peripheral artery interventions. Methods and Results - Index procedures resulting in femoropopliteal ST were compared with stent procedures without subsequent ST in the Excellence in Peripheral Artery Disease registry. The study data had a total of 724 cases of stent procedures and 604 unique patients. Femoropopliteal ST occurred in 26 of 604 patients (4.3%) over a median follow-up of 6 months post procedure. ST was more likely to occur in men (96.3% versus 82.2%; P=0.026) and to have an initial intervention for chronic total occlusions (88.5% versus 64.0%; P=0.01). There was no significant difference in ST between drug-coated and bare-metal stents (4.4% versus 3.4%; P=0.55), but the rate of ST was significantly higher with self-expanding covered stent grafts compared with bare-metal stents (10.6% versus 3.4%; P=0.02). ST was significantly associated with an increased risk of 12-month major adverse limb events (hazard ratio, 4.99; 95% confidence interval, 2.31-10.77; P<0.001) compared with no ST. On multivariate analysis, treatment of chronic total occlusion lesions (odds ratio, 3.46; 95% confidence interval, 0.98-12.20; P=0.05) and in-stent restenosis lesions (odds ratio, 5.30; 95% confidence interval, 1.83-15.32; P=0.002) were independently associated with an increased risk of ST. Conclusions - In a multicenter peripheral interventional registry, femoropopliteal ST occurred in 4.3% of patients who underwent stent procedures, and it was associated with treatment of chronic total occlusions and in-stent restenosis lesions, and had higher 12-month major adverse limb events.

KW - Confidence intervals

KW - Odds ratio

KW - Peripheral artery disease

KW - Stent

KW - Thrombosis

UR - http://www.scopus.com/inward/record.url?scp=84959452748&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84959452748&partnerID=8YFLogxK

U2 - 10.1161/CIRCINTERVENTIONS.115.002730

DO - 10.1161/CIRCINTERVENTIONS.115.002730

M3 - Article

C2 - 26839391

AN - SCOPUS:84959452748

VL - 9

JO - Circulation: Cardiovascular Interventions

JF - Circulation: Cardiovascular Interventions

SN - 1941-7640

IS - 2

M1 - e002730

ER -