Feline spongiform encephalopathy

fibril and PrP studies.

G. R. Pearson, J. M. Wyatt, T. J. Gruffydd-Jones, J. Hope, A. Chong, Robert Higgins, A. C. Scott, G. A. Wells

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

The brains from 18 cats were examined for the presence of the fibrils and modified PrP protein which are molecular diagnostic markers for scrapie-like diseases. Thirteen cats were referred with clinical neurological signs potentially indicative of feline spongiform encephalopathy (FSE). Of these, five had histopathological changes of FSE, five had other lesions of the central nervous system, and in three the brain was normal. The remaining five cats had no clinical neurological signs and were selected as controls. Fibrils and modified PrP protein were found in the brains of the five cats with FSE and in one of the cats with neurological signs but no histopathological changes in the central nervous system. Fibrils were present in the absence of modified PrP in the brains of two cats, one with neurological signs and a histologically confirmed meningioma, and one with no neurological signs and a histologically normal brain.

Original languageEnglish (US)
Pages (from-to)307-310
Number of pages4
JournalThe Veterinary record
Volume131
Issue number14
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

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prion diseases
Felidae
Brain Diseases
Cats
cats
Brain
brain
Central Nervous System
prions
Scrapie
central nervous system
Molecular Pathology
Meningioma
scrapie
lesions (animal)

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pearson, G. R., Wyatt, J. M., Gruffydd-Jones, T. J., Hope, J., Chong, A., Higgins, R., ... Wells, G. A. (1992). Feline spongiform encephalopathy: fibril and PrP studies. The Veterinary record, 131(14), 307-310. https://doi.org/10.1136/vr.131.14.307

Feline spongiform encephalopathy : fibril and PrP studies. / Pearson, G. R.; Wyatt, J. M.; Gruffydd-Jones, T. J.; Hope, J.; Chong, A.; Higgins, Robert; Scott, A. C.; Wells, G. A.

In: The Veterinary record, Vol. 131, No. 14, 01.01.1992, p. 307-310.

Research output: Contribution to journalArticle

Pearson, GR, Wyatt, JM, Gruffydd-Jones, TJ, Hope, J, Chong, A, Higgins, R, Scott, AC & Wells, GA 1992, 'Feline spongiform encephalopathy: fibril and PrP studies.', The Veterinary record, vol. 131, no. 14, pp. 307-310. https://doi.org/10.1136/vr.131.14.307
Pearson GR, Wyatt JM, Gruffydd-Jones TJ, Hope J, Chong A, Higgins R et al. Feline spongiform encephalopathy: fibril and PrP studies. The Veterinary record. 1992 Jan 1;131(14):307-310. https://doi.org/10.1136/vr.131.14.307
Pearson, G. R. ; Wyatt, J. M. ; Gruffydd-Jones, T. J. ; Hope, J. ; Chong, A. ; Higgins, Robert ; Scott, A. C. ; Wells, G. A. / Feline spongiform encephalopathy : fibril and PrP studies. In: The Veterinary record. 1992 ; Vol. 131, No. 14. pp. 307-310.
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