Feline polycystic kidney disease is linked to the PKD1 region

Amy E. Young, David S. Biller, Eric J. Herrgesell, Heather R. Roberts, Leslie A Lyons

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is a commonly inherited disorder (1/1000) in humans characterized by fluid-filled cysts in the kidneys. Defects in the PKD genes, PKD1 and PKD2, cause 85% and 15% of human ADPKD cases, respectively. Mutations in the PKHD1 gene cause autosomal recessive PKD (ARPKD). Mutations in several genes, including Nek8, cause PKD in mice. Although PKD affects 38% of Persian cats worldwide, making it the most prominent inherited feline disease, a causative gene has not been identified. Feline PKD is an autosomal dominant disease with clinical presentations similar to human ADPKD. Forty-three microsatellites were chosen from the feline genetic maps based on known homology with human chromosomal regions containing the PKD1, PKD2, PKHD1, and Nek8 genes. Linkage analysis using seven Persian cat pedigrees segregating for PKD has shown significant linkage and no recombinants (Z = 5.83, θ = 0) between the PKD disease phenotype and marker FCA476, which is within 10 cR of the feline PKD1 gene on Chromosome E3. This suggests that the PKD1 gene or another gene within this region may cause feline PKD. Further investigation into the cause of PKD will be valuable for feline health and provide insights into human ADPKD.

Original languageEnglish (US)
Pages (from-to)59-65
Number of pages7
JournalMammalian Genome
Volume16
Issue number1
DOIs
StatePublished - Jan 2005

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Polycystic Kidney Diseases
Felidae
Autosomal Dominant Polycystic Kidney
Genes
Cats
Cat Diseases
Cyst Fluid
Mutation
Pedigree
Microsatellite Repeats
Chromosomes
Phenotype
Kidney
Health

ASJC Scopus subject areas

  • Genetics

Cite this

Feline polycystic kidney disease is linked to the PKD1 region. / Young, Amy E.; Biller, David S.; Herrgesell, Eric J.; Roberts, Heather R.; Lyons, Leslie A.

In: Mammalian Genome, Vol. 16, No. 1, 01.2005, p. 59-65.

Research output: Contribution to journalArticle

Young, AE, Biller, DS, Herrgesell, EJ, Roberts, HR & Lyons, LA 2005, 'Feline polycystic kidney disease is linked to the PKD1 region', Mammalian Genome, vol. 16, no. 1, pp. 59-65. https://doi.org/10.1007/s00335-004-2412-2
Young, Amy E. ; Biller, David S. ; Herrgesell, Eric J. ; Roberts, Heather R. ; Lyons, Leslie A. / Feline polycystic kidney disease is linked to the PKD1 region. In: Mammalian Genome. 2005 ; Vol. 16, No. 1. pp. 59-65.
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