Feline malignant lymphomas: comparison of morphologic and immunologic characteristics.

C. A. Holmberg, J. S. Manning, Bennie Osburn

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Lymphoid cell populations from various hematopoietic tissues of normal cats (n = 22) and from cats with malignant lymphoma (n = 14 cats) were examined simultaneously for morphologic and immunologic features. Scanning electron microscopy and mitogen stimulation studies were not useful in identifying the B or T cell nature of malignant lymphomas. Cell markers successfully used to identify B cells were the presence of surface immunoglobulin by fluorescent-immunoglobulin staining procedures and the presence of complement receptors by EAC (erythrocyte, antibody, complement) rosette formation. The formation of rosettes with guinea pig erythrocytes was used to identify T cells. Using these cell surface markers, thymic lymphomas were found to be composed of T cells and alimentary lymphomas were found to be composed of B cells. The multicentric lymphomas lacked B or T cell surface markers. Classification by cytologic type of cell did not show any correlation with other values.

Original languageEnglish (US)
Pages (from-to)1455-1460
Number of pages6
JournalAmerican Journal of Veterinary Research
Volume37
Issue number12
StatePublished - Dec 1 1976
Externally publishedYes

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Felidae
lymphoma
Rosette Formation
Lymphoma
Cats
B-Lymphocytes
T-Cell Lymphoma
B-lymphocytes
cats
T-lymphocytes
Erythrocytes
T-Lymphocytes
Complement Receptors
B-Cell Antigen Receptors
immunoglobulins
B-Cell Lymphoma
Mitogens
complement
erythrocytes
Electron Scanning Microscopy

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Feline malignant lymphomas : comparison of morphologic and immunologic characteristics. / Holmberg, C. A.; Manning, J. S.; Osburn, Bennie.

In: American Journal of Veterinary Research, Vol. 37, No. 12, 01.12.1976, p. 1455-1460.

Research output: Contribution to journalArticle

Holmberg, C. A. ; Manning, J. S. ; Osburn, Bennie. / Feline malignant lymphomas : comparison of morphologic and immunologic characteristics. In: American Journal of Veterinary Research. 1976 ; Vol. 37, No. 12. pp. 1455-1460.
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