Abstract
Lymphoid cell populations from various hematopoietic tissues of normal cats (n = 22) and from cats with malignant lymphoma (n = 14 cats) were examined simultaneously for morphologic and immunologic features. Scanning electron microscopy and mitogen stimulation studies were not useful in identifying the B or T cell nature of malignant lymphomas. Cell markers successfully used to identify B cells were the presence of surface immunoglobulin by fluorescent-immunoglobulin staining procedures and the presence of complement receptors by EAC (erythrocyte, antibody, complement) rosette formation. The formation of rosettes with guinea pig erythrocytes was used to identify T cells. Using these cell surface markers, thymic lymphomas were found to be composed of T cells and alimentary lymphomas were found to be composed of B cells. The multicentric lymphomas lacked B or T cell surface markers. Classification by cytologic type of cell did not show any correlation with other values.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1455-1460 |
| Number of pages | 6 |
| Journal | American Journal of Veterinary Research |
| Volume | 37 |
| Issue number | 12 |
| State | Published - Dec 1 1976 |
| Externally published | Yes |
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Cite this
Feline malignant lymphomas : comparison of morphologic and immunologic characteristics. / Holmberg, C. A.; Manning, J. S.; Osburn, Bennie.
In: American Journal of Veterinary Research, Vol. 37, No. 12, 01.12.1976, p. 1455-1460.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Feline malignant lymphomas
T2 - comparison of morphologic and immunologic characteristics.
AU - Holmberg, C. A.
AU - Manning, J. S.
AU - Osburn, Bennie
PY - 1976/12/1
Y1 - 1976/12/1
N2 - Lymphoid cell populations from various hematopoietic tissues of normal cats (n = 22) and from cats with malignant lymphoma (n = 14 cats) were examined simultaneously for morphologic and immunologic features. Scanning electron microscopy and mitogen stimulation studies were not useful in identifying the B or T cell nature of malignant lymphomas. Cell markers successfully used to identify B cells were the presence of surface immunoglobulin by fluorescent-immunoglobulin staining procedures and the presence of complement receptors by EAC (erythrocyte, antibody, complement) rosette formation. The formation of rosettes with guinea pig erythrocytes was used to identify T cells. Using these cell surface markers, thymic lymphomas were found to be composed of T cells and alimentary lymphomas were found to be composed of B cells. The multicentric lymphomas lacked B or T cell surface markers. Classification by cytologic type of cell did not show any correlation with other values.
AB - Lymphoid cell populations from various hematopoietic tissues of normal cats (n = 22) and from cats with malignant lymphoma (n = 14 cats) were examined simultaneously for morphologic and immunologic features. Scanning electron microscopy and mitogen stimulation studies were not useful in identifying the B or T cell nature of malignant lymphomas. Cell markers successfully used to identify B cells were the presence of surface immunoglobulin by fluorescent-immunoglobulin staining procedures and the presence of complement receptors by EAC (erythrocyte, antibody, complement) rosette formation. The formation of rosettes with guinea pig erythrocytes was used to identify T cells. Using these cell surface markers, thymic lymphomas were found to be composed of T cells and alimentary lymphomas were found to be composed of B cells. The multicentric lymphomas lacked B or T cell surface markers. Classification by cytologic type of cell did not show any correlation with other values.
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UR - http://www.scopus.com/inward/citedby.url?scp=0017281322&partnerID=8YFLogxK
M3 - Article
C2 - 793460
AN - SCOPUS:0017281322
VL - 37
SP - 1455
EP - 1460
JO - American Journal of Veterinary Research
JF - American Journal of Veterinary Research
SN - 0002-9645
IS - 12
ER -