Abstract
Lymphoid cell populations from various hematopoietic tissues of normal cats (n = 22) and from cats with malignant lymphoma (n = 14 cats) were examined simultaneously for morphologic and immunologic features. Scanning electron microscopy and mitogen stimulation studies were not useful in identifying the B or T cell nature of malignant lymphomas. Cell markers successfully used to identify B cells were the presence of surface immunoglobulin by fluorescent-immunoglobulin staining procedures and the presence of complement receptors by EAC (erythrocyte, antibody, complement) rosette formation. The formation of rosettes with guinea pig erythrocytes was used to identify T cells. Using these cell surface markers, thymic lymphomas were found to be composed of T cells and alimentary lymphomas were found to be composed of B cells. The multicentric lymphomas lacked B or T cell surface markers. Classification by cytologic type of cell did not show any correlation with other values.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1455-1460 |
| Number of pages | 6 |
| Journal | American Journal of Veterinary Research |
| Volume | 37 |
| Issue number | 12 |
| State | Published - Dec 1 1976 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- veterinary(all)