Feline malignant lymphomas: comparison of morphologic and immunologic characteristics.

C. A. Holmberg, J. S. Manning, Bennie Osburn

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Lymphoid cell populations from various hematopoietic tissues of normal cats (n = 22) and from cats with malignant lymphoma (n = 14 cats) were examined simultaneously for morphologic and immunologic features. Scanning electron microscopy and mitogen stimulation studies were not useful in identifying the B or T cell nature of malignant lymphomas. Cell markers successfully used to identify B cells were the presence of surface immunoglobulin by fluorescent-immunoglobulin staining procedures and the presence of complement receptors by EAC (erythrocyte, antibody, complement) rosette formation. The formation of rosettes with guinea pig erythrocytes was used to identify T cells. Using these cell surface markers, thymic lymphomas were found to be composed of T cells and alimentary lymphomas were found to be composed of B cells. The multicentric lymphomas lacked B or T cell surface markers. Classification by cytologic type of cell did not show any correlation with other values.

Original languageEnglish (US)
Pages (from-to)1455-1460
Number of pages6
JournalAmerican Journal of Veterinary Research
Issue number12
StatePublished - Dec 1 1976
Externally publishedYes


ASJC Scopus subject areas

  • veterinary(all)

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