Abstract
Feline infectious peritonitis (FIP) is a fatal immune-mediated vasculitis of felids caused by a mutant form of a common feline enteric virus, feline enteric coronavirus. The virus can attack many organ systems and causes a broad range of signs, commonly including weight loss and fever. Regardless of presenta-tion, FIP is ultimately fatal and often presents a diagnostic challenge. In May 2010, a malnour-ished young adult male mountain lion (Puma concolor) from Kern County, California, USA was euthanized because of concern for public safety, and a postmortem examination was performed. Gross necropsy and histopathologic examination revealed necrotizing, multifocal myocarditis; necrotizing, neutrophilic, and his-tiocytic myositis and vasculitis of the tunica muscularis layer of the small and large intes-tines; and embolic, multifocal, interstitial pneu-monia. Feline coronavirus antigen was detect-ed in both the heart and intestinal tissue by immunohistochemistry. A PCR for coronavirus performed on kidney tissue was positive, con-firming a diagnosis of FIP. Although coronavirus infection has been documented in mountain lions by serology, this is the first confirmed report of FIP.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 408-412 |
| Number of pages | 5 |
| Journal | Journal of Wildlife Diseases |
| Volume | 49 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 1 2013 |
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Keywords
- FeCV
- Feline coronavirus
- FIP
- Immunohistochemistry
- Mountain lion
ASJC Scopus subject areas
- Ecology, Evolution, Behavior and Systematics
- Ecology
Cite this
Feline infectious peritonitis in a mountain lion (Puma concolor), California, USA. / Stephenson, Nicole; Swift, Pamela; Moeller, Robert B.; Worth, S. Joy; Foley, Janet E.
In: Journal of Wildlife Diseases, Vol. 49, No. 2, 01.04.2013, p. 408-412.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Feline infectious peritonitis in a mountain lion (Puma concolor), California, USA
AU - Stephenson, Nicole
AU - Swift, Pamela
AU - Moeller, Robert B.
AU - Worth, S. Joy
AU - Foley, Janet E
PY - 2013/4/1
Y1 - 2013/4/1
N2 - Feline infectious peritonitis (FIP) is a fatal immune-mediated vasculitis of felids caused by a mutant form of a common feline enteric virus, feline enteric coronavirus. The virus can attack many organ systems and causes a broad range of signs, commonly including weight loss and fever. Regardless of presenta-tion, FIP is ultimately fatal and often presents a diagnostic challenge. In May 2010, a malnour-ished young adult male mountain lion (Puma concolor) from Kern County, California, USA was euthanized because of concern for public safety, and a postmortem examination was performed. Gross necropsy and histopathologic examination revealed necrotizing, multifocal myocarditis; necrotizing, neutrophilic, and his-tiocytic myositis and vasculitis of the tunica muscularis layer of the small and large intes-tines; and embolic, multifocal, interstitial pneu-monia. Feline coronavirus antigen was detect-ed in both the heart and intestinal tissue by immunohistochemistry. A PCR for coronavirus performed on kidney tissue was positive, con-firming a diagnosis of FIP. Although coronavirus infection has been documented in mountain lions by serology, this is the first confirmed report of FIP.
AB - Feline infectious peritonitis (FIP) is a fatal immune-mediated vasculitis of felids caused by a mutant form of a common feline enteric virus, feline enteric coronavirus. The virus can attack many organ systems and causes a broad range of signs, commonly including weight loss and fever. Regardless of presenta-tion, FIP is ultimately fatal and often presents a diagnostic challenge. In May 2010, a malnour-ished young adult male mountain lion (Puma concolor) from Kern County, California, USA was euthanized because of concern for public safety, and a postmortem examination was performed. Gross necropsy and histopathologic examination revealed necrotizing, multifocal myocarditis; necrotizing, neutrophilic, and his-tiocytic myositis and vasculitis of the tunica muscularis layer of the small and large intes-tines; and embolic, multifocal, interstitial pneu-monia. Feline coronavirus antigen was detect-ed in both the heart and intestinal tissue by immunohistochemistry. A PCR for coronavirus performed on kidney tissue was positive, con-firming a diagnosis of FIP. Although coronavirus infection has been documented in mountain lions by serology, this is the first confirmed report of FIP.
KW - FeCV
KW - Feline coronavirus
KW - FIP
KW - Immunohistochemistry
KW - Mountain lion
UR - http://www.scopus.com/inward/record.url?scp=84876036068&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84876036068&partnerID=8YFLogxK
U2 - 10.7589/2012-08-210
DO - 10.7589/2012-08-210
M3 - Article
C2 - 23568918
AN - SCOPUS:84876036068
VL - 49
SP - 408
EP - 412
JO - Journal of Wildlife Diseases
JF - Journal of Wildlife Diseases
SN - 0090-3558
IS - 2
ER -