Feline Immunodeficiency Virus Infects both CD4+ and CD8+ T Lymphocytes

Wendy C. Brown; Ledawn Bissey; Kathleen S. Logan; Niels C Pedersen; John H. Elder; Ellen W. Collisson

Feline Immunodeficiency Virus Infects both CD4+ and CD8+ T Lymphocytes

Wendy C. Brown, Ledawn Bissey, Kathleen S. Logan, Niels C Pedersen, John H. Elder, Ellen W. Collisson

Medicine and Epidemiology

Research output: Contribution to journal › Article › peer-review

100 Scopus citations

Abstract

Monoclonal populations of feline T cells, derived from a specific-pathogen-free cat and expressing either the CD4 or CD8 surface antigen, were infected in vitro with two geographically distinct isolates of feline immunodeficiency virus (FIV). Both infected T-cell subsets exhibited decreased cell viability, expressed FIV-encoded proteins, and generated reverse transcriptase activity. All clones examined retained their original surface phenotype after infection. It appears, therefore, that both CD4⁺ and CD8⁺ T cells may be productively infected by FIV in vivo.

Original language	English (US)
Pages (from-to)	3359-3364
Number of pages	6
Journal	Journal of Virology
Volume	65
Issue number	6
State	Published - Jun 1991

ASJC Scopus subject areas

Immunology

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title = "Feline Immunodeficiency Virus Infects both CD4+ and CD8+ T Lymphocytes",

abstract = "Monoclonal populations of feline T cells, derived from a specific-pathogen-free cat and expressing either the CD4 or CD8 surface antigen, were infected in vitro with two geographically distinct isolates of feline immunodeficiency virus (FIV). Both infected T-cell subsets exhibited decreased cell viability, expressed FIV-encoded proteins, and generated reverse transcriptase activity. All clones examined retained their original surface phenotype after infection. It appears, therefore, that both CD4+ and CD8+ T cells may be productively infected by FIV in vivo.",

author = "Brown, {Wendy C.} and Ledawn Bissey and Logan, {Kathleen S.} and Pedersen, {Niels C} and Elder, {John H.} and Collisson, {Ellen W.}",

year = "1991",

month = jun,

language = "English (US)",

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T1 - Feline Immunodeficiency Virus Infects both CD4+ and CD8+ T Lymphocytes

AU - Brown, Wendy C.

AU - Bissey, Ledawn

AU - Logan, Kathleen S.

AU - Pedersen, Niels C

AU - Elder, John H.

AU - Collisson, Ellen W.

PY - 1991/6

Y1 - 1991/6

N2 - Monoclonal populations of feline T cells, derived from a specific-pathogen-free cat and expressing either the CD4 or CD8 surface antigen, were infected in vitro with two geographically distinct isolates of feline immunodeficiency virus (FIV). Both infected T-cell subsets exhibited decreased cell viability, expressed FIV-encoded proteins, and generated reverse transcriptase activity. All clones examined retained their original surface phenotype after infection. It appears, therefore, that both CD4+ and CD8+ T cells may be productively infected by FIV in vivo.

AB - Monoclonal populations of feline T cells, derived from a specific-pathogen-free cat and expressing either the CD4 or CD8 surface antigen, were infected in vitro with two geographically distinct isolates of feline immunodeficiency virus (FIV). Both infected T-cell subsets exhibited decreased cell viability, expressed FIV-encoded proteins, and generated reverse transcriptase activity. All clones examined retained their original surface phenotype after infection. It appears, therefore, that both CD4+ and CD8+ T cells may be productively infected by FIV in vivo.

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