Feline Immunodeficiency Virus Infects both CD4+ and CD8+ T Lymphocytes

Wendy C. Brown, Ledawn Bissey, Kathleen S. Logan, Niels C Pedersen, John H. Elder, Ellen W. Collisson

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

Monoclonal populations of feline T cells, derived from a specific-pathogen-free cat and expressing either the CD4 or CD8 surface antigen, were infected in vitro with two geographically distinct isolates of feline immunodeficiency virus (FIV). Both infected T-cell subsets exhibited decreased cell viability, expressed FIV-encoded proteins, and generated reverse transcriptase activity. All clones examined retained their original surface phenotype after infection. It appears, therefore, that both CD4+ and CD8+ T cells may be productively infected by FIV in vivo.

Original languageEnglish (US)
Pages (from-to)3359-3364
Number of pages6
JournalJournal of Virology
Volume65
Issue number6
StatePublished - Jun 1991

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Feline Immunodeficiency Virus
Feline immunodeficiency virus
T-lymphocytes
T-Lymphocytes
cats
CD8 Antigens
Specific Pathogen-Free Organisms
RNA-directed DNA polymerase
RNA-Directed DNA Polymerase
Felidae
surface antigens
T-Lymphocyte Subsets
Surface Antigens
cell viability
Cell Survival
Cats
Clone Cells
clones
Phenotype
phenotype

ASJC Scopus subject areas

  • Immunology

Cite this

Brown, W. C., Bissey, L., Logan, K. S., Pedersen, N. C., Elder, J. H., & Collisson, E. W. (1991). Feline Immunodeficiency Virus Infects both CD4+ and CD8+ T Lymphocytes. Journal of Virology, 65(6), 3359-3364.

Feline Immunodeficiency Virus Infects both CD4+ and CD8+ T Lymphocytes. / Brown, Wendy C.; Bissey, Ledawn; Logan, Kathleen S.; Pedersen, Niels C; Elder, John H.; Collisson, Ellen W.

In: Journal of Virology, Vol. 65, No. 6, 06.1991, p. 3359-3364.

Research output: Contribution to journalArticle

Brown, WC, Bissey, L, Logan, KS, Pedersen, NC, Elder, JH & Collisson, EW 1991, 'Feline Immunodeficiency Virus Infects both CD4+ and CD8+ T Lymphocytes', Journal of Virology, vol. 65, no. 6, pp. 3359-3364.
Brown WC, Bissey L, Logan KS, Pedersen NC, Elder JH, Collisson EW. Feline Immunodeficiency Virus Infects both CD4+ and CD8+ T Lymphocytes. Journal of Virology. 1991 Jun;65(6):3359-3364.
Brown, Wendy C. ; Bissey, Ledawn ; Logan, Kathleen S. ; Pedersen, Niels C ; Elder, John H. ; Collisson, Ellen W. / Feline Immunodeficiency Virus Infects both CD4+ and CD8+ T Lymphocytes. In: Journal of Virology. 1991 ; Vol. 65, No. 6. pp. 3359-3364.
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