Abstract
Monoclonal populations of feline T cells, derived from a specific-pathogen-free cat and expressing either the CD4 or CD8 surface antigen, were infected in vitro with two geographically distinct isolates of feline immunodeficiency virus (FIV). Both infected T-cell subsets exhibited decreased cell viability, expressed FIV-encoded proteins, and generated reverse transcriptase activity. All clones examined retained their original surface phenotype after infection. It appears, therefore, that both CD4+ and CD8+ T cells may be productively infected by FIV in vivo.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3359-3364 |
| Number of pages | 6 |
| Journal | Journal of Virology |
| Volume | 65 |
| Issue number | 6 |
| State | Published - Jun 1991 |
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ASJC Scopus subject areas
- Immunology
Cite this
Feline Immunodeficiency Virus Infects both CD4+ and CD8+ T Lymphocytes. / Brown, Wendy C.; Bissey, Ledawn; Logan, Kathleen S.; Pedersen, Niels C; Elder, John H.; Collisson, Ellen W.
In: Journal of Virology, Vol. 65, No. 6, 06.1991, p. 3359-3364.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Feline Immunodeficiency Virus Infects both CD4+ and CD8+ T Lymphocytes
AU - Brown, Wendy C.
AU - Bissey, Ledawn
AU - Logan, Kathleen S.
AU - Pedersen, Niels C
AU - Elder, John H.
AU - Collisson, Ellen W.
PY - 1991/6
Y1 - 1991/6
N2 - Monoclonal populations of feline T cells, derived from a specific-pathogen-free cat and expressing either the CD4 or CD8 surface antigen, were infected in vitro with two geographically distinct isolates of feline immunodeficiency virus (FIV). Both infected T-cell subsets exhibited decreased cell viability, expressed FIV-encoded proteins, and generated reverse transcriptase activity. All clones examined retained their original surface phenotype after infection. It appears, therefore, that both CD4+ and CD8+ T cells may be productively infected by FIV in vivo.
AB - Monoclonal populations of feline T cells, derived from a specific-pathogen-free cat and expressing either the CD4 or CD8 surface antigen, were infected in vitro with two geographically distinct isolates of feline immunodeficiency virus (FIV). Both infected T-cell subsets exhibited decreased cell viability, expressed FIV-encoded proteins, and generated reverse transcriptase activity. All clones examined retained their original surface phenotype after infection. It appears, therefore, that both CD4+ and CD8+ T cells may be productively infected by FIV in vivo.
UR - http://www.scopus.com/inward/record.url?scp=0025936540&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025936540&partnerID=8YFLogxK
M3 - Article
C2 - 1709703
AN - SCOPUS:0025936540
VL - 65
SP - 3359
EP - 3364
JO - Journal of Virology
JF - Journal of Virology
SN - 0022-538X
IS - 6
ER -