Abstract
Monoclonal populations of feline T cells, derived from a specific-pathogen-free cat and expressing either the CD4 or CD8 surface antigen, were infected in vitro with two geographically distinct isolates of feline immunodeficiency virus (FIV). Both infected T-cell subsets exhibited decreased cell viability, expressed FIV-encoded proteins, and generated reverse transcriptase activity. All clones examined retained their original surface phenotype after infection. It appears, therefore, that both CD4+ and CD8+ T cells may be productively infected by FIV in vivo.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3359-3364 |
| Number of pages | 6 |
| Journal | Journal of Virology |
| Volume | 65 |
| Issue number | 6 |
| State | Published - Jun 1991 |
ASJC Scopus subject areas
- Immunology
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Brown, W. C., Bissey, L., Logan, K. S., Pedersen, N. C., Elder, J. H., & Collisson, E. W. (1991). Feline Immunodeficiency Virus Infects both CD4+ and CD8+ T Lymphocytes. Journal of Virology, 65(6), 3359-3364.