Feline Immunodeficiency Virus Infects both CD4+ and CD8+ T Lymphocytes

Wendy C. Brown, Ledawn Bissey, Kathleen S. Logan, Niels C Pedersen, John H. Elder, Ellen W. Collisson

Research output: Contribution to journalArticle

98 Scopus citations

Abstract

Monoclonal populations of feline T cells, derived from a specific-pathogen-free cat and expressing either the CD4 or CD8 surface antigen, were infected in vitro with two geographically distinct isolates of feline immunodeficiency virus (FIV). Both infected T-cell subsets exhibited decreased cell viability, expressed FIV-encoded proteins, and generated reverse transcriptase activity. All clones examined retained their original surface phenotype after infection. It appears, therefore, that both CD4+ and CD8+ T cells may be productively infected by FIV in vivo.

Original languageEnglish (US)
Pages (from-to)3359-3364
Number of pages6
JournalJournal of Virology
Volume65
Issue number6
StatePublished - Jun 1991

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ASJC Scopus subject areas

  • Immunology

Cite this

Brown, W. C., Bissey, L., Logan, K. S., Pedersen, N. C., Elder, J. H., & Collisson, E. W. (1991). Feline Immunodeficiency Virus Infects both CD4+ and CD8+ T Lymphocytes. Journal of Virology, 65(6), 3359-3364.