Feeding preterm infants after hospital discharge: Growth and development at 18 months of age

R. J. Cooke, N. D. Embleton, I. J. Griffin, J. C. Wells, K. P. McCormick

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

We have shown that preterm infants fed a preterm formula grow better than those fed a standard term infant formula after hospital discharge. The purpose of this follow-up study was to determine whether improved early growth was associated with later growth and development. Preterm infants (≤1750 g birth weight, ≤34 wk gestation) were randomized to be fed either a preterm infant formula (discharge to 6 mo corrected age), or a term formula (discharge to 6 mo), or the preterm (discharge to term) and the term formula (term to 6 mo). Anthropometry was performed at 12 wk and 6, 12, and 18 mo. Mental and psychomotor development were assessed using the Bayley Scales of Infant Development II at 18 mo. Differences in growth observed at 12 wk were maintained at 18 mo. At 18 mo, boys fed the preterm formula were 1.0 kg heavier, 2 cm longer, and had a 1.0 cm greater occipitofrontal circumference than boys fed the term formula. Boys fed the preterm formula were also 600 g heavier and 2 cm longer than girls fed the preterm formula. However, no differences were noted in MDI or PDI between boys fed the preterm formula and boys fed the term formula or between the boys fed preterm formula and girls fed the preterm formula. Overall, boys had significantly lower MDI than girls (mean difference, 6.0; p < 0.01), primarily reflecting lower scores in boys fed the term formula. Thus, early diet has long-term effects on growth but not development at 18 mo of age. Sex remains an important confounding variable when assessing growth and developmental outcome in these high-risk infants.

Original languageEnglish (US)
Pages (from-to)719-722
Number of pages4
JournalPediatric Research
Volume49
Issue number5
StatePublished - 2001
Externally publishedYes

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Growth and Development
Premature Infants
Infant Formula
Growth
Anthropometry
Confounding Factors (Epidemiology)
Child Development
Birth Weight
Diet
Pregnancy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Cooke, R. J., Embleton, N. D., Griffin, I. J., Wells, J. C., & McCormick, K. P. (2001). Feeding preterm infants after hospital discharge: Growth and development at 18 months of age. Pediatric Research, 49(5), 719-722.

Feeding preterm infants after hospital discharge : Growth and development at 18 months of age. / Cooke, R. J.; Embleton, N. D.; Griffin, I. J.; Wells, J. C.; McCormick, K. P.

In: Pediatric Research, Vol. 49, No. 5, 2001, p. 719-722.

Research output: Contribution to journalArticle

Cooke, RJ, Embleton, ND, Griffin, IJ, Wells, JC & McCormick, KP 2001, 'Feeding preterm infants after hospital discharge: Growth and development at 18 months of age', Pediatric Research, vol. 49, no. 5, pp. 719-722.
Cooke RJ, Embleton ND, Griffin IJ, Wells JC, McCormick KP. Feeding preterm infants after hospital discharge: Growth and development at 18 months of age. Pediatric Research. 2001;49(5):719-722.
Cooke, R. J. ; Embleton, N. D. ; Griffin, I. J. ; Wells, J. C. ; McCormick, K. P. / Feeding preterm infants after hospital discharge : Growth and development at 18 months of age. In: Pediatric Research. 2001 ; Vol. 49, No. 5. pp. 719-722.
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