Feeding preterm infants after hospital discharge: Effect of dietary manipulation on nutrient intake and growth

R. J. Cooke, I. J. Griffin, K. McCormick, J. C K Wells, J. S. Smith, S. J. Robinson, M. Leighton

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

The objective of this study was to compare formula intake, the time of weaning, and growth in preterm infants (≤1750-g birth weight, ≤34-wk gestation) fed a standard term or preterm infant formula after initial hospital discharge. Infants were randomized at hospital discharge to be fed a preterm infant formula from discharge to 6 mo corrected age (group A), a term formula from discharge to 6 mo (group B), or the preterm formula (discharge to term) and the term formula (term to 6 mo (group C). Infants were seen biweekly (discharge to term) and monthly (term to 6 mo), when intake was measured and anthropometry and blood sampling were performed. The results were analyzed using ANOVA. Although nutrient intake was similar, at 6 mo girls were lighter (6829 versus 7280 g) and shorter (64.4 versus 66.0 cm) than boys (p < 0.05). Patient characteristics were similar between the treatment groups. Although the volume of intake differed (B > C > A; p < 0.001), energy intake was similar in the groups. Because of differences in formula composition, protein, calcium, and phosphorus intakes differed (B < C < A; p < 0.001). Lower protein intakes were related to lower blood urea nitrogen levels (B < C < A; p < 0.001). At 6 mo, infant boys in B and C were lighter (6933, 6660 < 7949 g), shorter (65.3, 64.9 < 67.1 cm), and had a smaller head circumference (43.7, 43.7 < 44.8 cm; p < 0.05) than infants in group A. Preterm infants were found to increase their volume of intake to compensate for differences in energy density between formulas. After hospital discharge, infant boys fed a preterm formula grew faster than infant girls fed a preterm formula or infant boys fed a term formula.

Original languageEnglish (US)
Pages (from-to)355-360
Number of pages6
JournalPediatric Research
Volume43
Issue number3
StatePublished - Mar 1998
Externally publishedYes

Fingerprint

Premature Infants
Food
Infant Formula
Growth
Anthropometry
Blood Urea Nitrogen
Weaning
Energy Intake
Birth Weight
Phosphorus
Analysis of Variance
Proteins
Age Groups
Head
Calcium
Pregnancy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Cooke, R. J., Griffin, I. J., McCormick, K., Wells, J. C. K., Smith, J. S., Robinson, S. J., & Leighton, M. (1998). Feeding preterm infants after hospital discharge: Effect of dietary manipulation on nutrient intake and growth. Pediatric Research, 43(3), 355-360.

Feeding preterm infants after hospital discharge : Effect of dietary manipulation on nutrient intake and growth. / Cooke, R. J.; Griffin, I. J.; McCormick, K.; Wells, J. C K; Smith, J. S.; Robinson, S. J.; Leighton, M.

In: Pediatric Research, Vol. 43, No. 3, 03.1998, p. 355-360.

Research output: Contribution to journalArticle

Cooke, RJ, Griffin, IJ, McCormick, K, Wells, JCK, Smith, JS, Robinson, SJ & Leighton, M 1998, 'Feeding preterm infants after hospital discharge: Effect of dietary manipulation on nutrient intake and growth', Pediatric Research, vol. 43, no. 3, pp. 355-360.
Cooke RJ, Griffin IJ, McCormick K, Wells JCK, Smith JS, Robinson SJ et al. Feeding preterm infants after hospital discharge: Effect of dietary manipulation on nutrient intake and growth. Pediatric Research. 1998 Mar;43(3):355-360.
Cooke, R. J. ; Griffin, I. J. ; McCormick, K. ; Wells, J. C K ; Smith, J. S. ; Robinson, S. J. ; Leighton, M. / Feeding preterm infants after hospital discharge : Effect of dietary manipulation on nutrient intake and growth. In: Pediatric Research. 1998 ; Vol. 43, No. 3. pp. 355-360.
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