Feedback-driven trial-by-trial learning in autism spectrum disorders

Marjorie Solomon Friedman, Michael J. Frank, John D Ragland, Anne C. Smith, Tara A Niendam, Tyler A. Lesh, David S. Grayson, Jonathan S. Beck, John C. Matter, Cameron S Carter

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective: Impairments in learning are central to autism spectrum disorders. The authors investigated the cognitive and neural basis of these deficits in young adults with autism spectrum disorders using a well-characterized probabilistic reinforcement learning paradigm. Method: The probabilistic selection task was implemented among matched participants with autism spectrum disorders (N=22) and with typical development (N=25), aged 18-40 years, using rapid event-related functional MRI. Participants were trained to choose the correct stimulus in high-probability (AB), medium-probability (CD), and low-probability (EF) pairs, presented with valid feedback 80%, 70%, and 60% of the time, respectively. Whole-brain voxel-wise and parametric modulator analyses examined early and late learning during the stimulus and feedback epochs of the task. Results: The groups exhibited comparable performance on medium-and low-probability pairs. Typically developing persons showed higher accuracy on the high-probability pair, better win-stay performance (selection of the previously rewarded stimulus on the next trial of that type), and more robust recruitment of the anterior and medial prefrontal cortex during the stimulus epoch, suggesting development of an intact reward-based working memory for recent stimulus values. Throughout the feedback epoch, individuals with autism spectrum disorders exhibited greater recruitment of the anterior cingulate and orbito-frontal cortices compared with individuals with typical development, indicating continuing trial-by-trial activity related to feedback processing. Conclusions: Individuals with autism spectrum disorders exhibit learning deficits reflecting impaired ability to develop an effective reward-based working memory to guide stimulus selection. Instead, they continue to rely on trial-by-trial feedback processing to support learning dependent upon engagement of the anterior cingulate and orbito-frontal cortices.

Original languageEnglish (US)
Pages (from-to)173-181
Number of pages9
JournalAmerican Journal of Psychiatry
Volume172
Issue number2
DOIs
StatePublished - Feb 1 2015

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Learning
Gyrus Cinguli
Frontal Lobe
Reward
Short-Term Memory
Aptitude
Prefrontal Cortex
Young Adult
Magnetic Resonance Imaging
Autism Spectrum Disorder
Autism Spectrum Disorders
Stimulus
Brain
Working Memory
Cortex

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Arts and Humanities (miscellaneous)

Cite this

Feedback-driven trial-by-trial learning in autism spectrum disorders. / Friedman, Marjorie Solomon; Frank, Michael J.; Ragland, John D; Smith, Anne C.; Niendam, Tara A; Lesh, Tyler A.; Grayson, David S.; Beck, Jonathan S.; Matter, John C.; Carter, Cameron S.

In: American Journal of Psychiatry, Vol. 172, No. 2, 01.02.2015, p. 173-181.

Research output: Contribution to journalArticle

Friedman, Marjorie Solomon ; Frank, Michael J. ; Ragland, John D ; Smith, Anne C. ; Niendam, Tara A ; Lesh, Tyler A. ; Grayson, David S. ; Beck, Jonathan S. ; Matter, John C. ; Carter, Cameron S. / Feedback-driven trial-by-trial learning in autism spectrum disorders. In: American Journal of Psychiatry. 2015 ; Vol. 172, No. 2. pp. 173-181.
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