Features of polycythemia vera in the 8p12 myeloproliferative syndrome

Jeanna L Welborn; Shelly Fenner; Robert Parks

doi:10.1016/j.cancergencyto.2010.01.013

Features of polycythemia vera in the 8p12 myeloproliferative syndrome

Jeanna L Welborn, Shelly Fenner, Robert Parks

Hematology and Oncology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The 8p12 myeloproliferative syndrome is a distinct myeloid disorder associated with a translocation involving chromosome region 8p12 (HUGO nomenclature). It is characterized by leukocytosis, eosinophilia, and a concurrent or rapid transformation to a T-cell lymphoblastic lymphoma. We report a case of polycythemia vera as a clinical presentation of the 8p12 myeloproliferative syndrome and review the literature. Atypical features in patients with polycythemia vera should be investigated with cytogenetic evaluation.

Original language	English (US)
Pages (from-to)	53-55
Number of pages	3
Journal	Cancer Genetics and Cytogenetics
Volume	199
Issue number	1
DOIs	https://doi.org/10.1016/j.cancergencyto.2010.01.013
State	Published - May 2010

ASJC Scopus subject areas

Cancer Research
Genetics
Molecular Biology

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abstract = "The 8p12 myeloproliferative syndrome is a distinct myeloid disorder associated with a translocation involving chromosome region 8p12 (HUGO nomenclature). It is characterized by leukocytosis, eosinophilia, and a concurrent or rapid transformation to a T-cell lymphoblastic lymphoma. We report a case of polycythemia vera as a clinical presentation of the 8p12 myeloproliferative syndrome and review the literature. Atypical features in patients with polycythemia vera should be investigated with cytogenetic evaluation.",

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AB - The 8p12 myeloproliferative syndrome is a distinct myeloid disorder associated with a translocation involving chromosome region 8p12 (HUGO nomenclature). It is characterized by leukocytosis, eosinophilia, and a concurrent or rapid transformation to a T-cell lymphoblastic lymphoma. We report a case of polycythemia vera as a clinical presentation of the 8p12 myeloproliferative syndrome and review the literature. Atypical features in patients with polycythemia vera should be investigated with cytogenetic evaluation.

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