Feature-based VS. Intensity-based brain image registration: Comprehensive comparison using mutual information

L. A. Teverovskiy, O. T. Carmichael, H. J. Aizenstein, N. Lazar, Y. Liu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

We propose a mutual information-based method for quantitative evaluation of the deformable registration algorithms at three levels: global, voxel-wise and anatomical structure. We compare two fully deformable registration algorithms: feature-based HAMMER and a set of intensity-based algorithms (FEMDemons) in the ITK package. Evaluation is carried out using the AAL template image with 116 labeled anatomical structures and a set of 59 MR brain images: 20 normal controls (CTL), 20 Alzheimer's disease patients (AD) and 19 mild cognitive impairment patients (MCI). We show that both HAMMER and FEM-Demons perform significantly better than an affine registration algorithm, FLIRT, at all three levels. At the global level, FEM-Demons outperforms HAMMER on the images of AD and MCI patients. At the local and anatomical levels, FEM-Demons and HAMMER dominate each other on different brain regions.

Original languageEnglish (US)
Title of host publication2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings
Pages576-579
Number of pages4
DOIs
StatePublished - 2007
Event2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro; ISBI'07 - Arlington, VA, United States
Duration: Apr 12 2007Apr 15 2007

Other

Other2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro; ISBI'07
CountryUnited States
CityArlington, VA
Period4/12/074/15/07

Keywords

  • Deformable registration evaluation
  • False discovery rate
  • Mutual information

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Medicine(all)

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    Teverovskiy, L. A., Carmichael, O. T., Aizenstein, H. J., Lazar, N., & Liu, Y. (2007). Feature-based VS. Intensity-based brain image registration: Comprehensive comparison using mutual information. In 2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings (pp. 576-579). [4193351] https://doi.org/10.1109/ISBI.2007.356917