Feature article: Estrogen and the aging hippocampal synapse

Michelle M. Adams, John Morrison

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations


The ramifications of endocrine and neural senescence converge in the hippocampus, particularly with respect to glutamatergic synapses. In this review, we will focus on current literature suggesting that potential synaptic alterations induced by estrogen in the hippocampus are mediated through interactions between ER-α and NMDA receptors. In addition, we will examine the data suggesting that these interactions may be uncoupled with aging. These studies demonstrate that while estrogen helps retain a youthful synaptic phenotype by some measures, the aged synapse may differ from the young synapse in several key respects that impact plasticity in general, and endocrine influences on the synapse, in particular.

Original languageEnglish (US)
Pages (from-to)1271-1275
Number of pages5
JournalCerebral Cortex
Issue number12
StatePublished - Dec 1 2003
Externally publishedYes

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience


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