Feature article

Estrogen and the aging hippocampal synapse

Michelle M. Adams, John Morrison

Research output: Contribution to journalReview article

35 Citations (Scopus)

Abstract

The ramifications of endocrine and neural senescence converge in the hippocampus, particularly with respect to glutamatergic synapses. In this review, we will focus on current literature suggesting that potential synaptic alterations induced by estrogen in the hippocampus are mediated through interactions between ER-α and NMDA receptors. In addition, we will examine the data suggesting that these interactions may be uncoupled with aging. These studies demonstrate that while estrogen helps retain a youthful synaptic phenotype by some measures, the aged synapse may differ from the young synapse in several key respects that impact plasticity in general, and endocrine influences on the synapse, in particular.

Original languageEnglish (US)
Pages (from-to)1271-1275
Number of pages5
JournalCerebral Cortex
Volume13
Issue number12
DOIs
StatePublished - Dec 1 2003
Externally publishedYes

Fingerprint

Synapses
Estrogens
Hippocampus
Synaptic Potentials
N-Methyl-D-Aspartate Receptors
Phenotype

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Feature article : Estrogen and the aging hippocampal synapse. / Adams, Michelle M.; Morrison, John.

In: Cerebral Cortex, Vol. 13, No. 12, 01.12.2003, p. 1271-1275.

Research output: Contribution to journalReview article

Adams, Michelle M. ; Morrison, John. / Feature article : Estrogen and the aging hippocampal synapse. In: Cerebral Cortex. 2003 ; Vol. 13, No. 12. pp. 1271-1275.
@article{261ac8250a2547f1b66958ca8fe499fc,
title = "Feature article: Estrogen and the aging hippocampal synapse",
abstract = "The ramifications of endocrine and neural senescence converge in the hippocampus, particularly with respect to glutamatergic synapses. In this review, we will focus on current literature suggesting that potential synaptic alterations induced by estrogen in the hippocampus are mediated through interactions between ER-α and NMDA receptors. In addition, we will examine the data suggesting that these interactions may be uncoupled with aging. These studies demonstrate that while estrogen helps retain a youthful synaptic phenotype by some measures, the aged synapse may differ from the young synapse in several key respects that impact plasticity in general, and endocrine influences on the synapse, in particular.",
author = "Adams, {Michelle M.} and John Morrison",
year = "2003",
month = "12",
day = "1",
doi = "10.1093/cercor/bhg078",
language = "English (US)",
volume = "13",
pages = "1271--1275",
journal = "Cerebral Cortex",
issn = "1047-3211",
publisher = "Oxford University Press",
number = "12",

}

TY - JOUR

T1 - Feature article

T2 - Estrogen and the aging hippocampal synapse

AU - Adams, Michelle M.

AU - Morrison, John

PY - 2003/12/1

Y1 - 2003/12/1

N2 - The ramifications of endocrine and neural senescence converge in the hippocampus, particularly with respect to glutamatergic synapses. In this review, we will focus on current literature suggesting that potential synaptic alterations induced by estrogen in the hippocampus are mediated through interactions between ER-α and NMDA receptors. In addition, we will examine the data suggesting that these interactions may be uncoupled with aging. These studies demonstrate that while estrogen helps retain a youthful synaptic phenotype by some measures, the aged synapse may differ from the young synapse in several key respects that impact plasticity in general, and endocrine influences on the synapse, in particular.

AB - The ramifications of endocrine and neural senescence converge in the hippocampus, particularly with respect to glutamatergic synapses. In this review, we will focus on current literature suggesting that potential synaptic alterations induced by estrogen in the hippocampus are mediated through interactions between ER-α and NMDA receptors. In addition, we will examine the data suggesting that these interactions may be uncoupled with aging. These studies demonstrate that while estrogen helps retain a youthful synaptic phenotype by some measures, the aged synapse may differ from the young synapse in several key respects that impact plasticity in general, and endocrine influences on the synapse, in particular.

UR - http://www.scopus.com/inward/record.url?scp=0344412913&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0344412913&partnerID=8YFLogxK

U2 - 10.1093/cercor/bhg078

DO - 10.1093/cercor/bhg078

M3 - Review article

VL - 13

SP - 1271

EP - 1275

JO - Cerebral Cortex

JF - Cerebral Cortex

SN - 1047-3211

IS - 12

ER -