Erste erfahrungen mit einem flächendetektor-volumen-CT (fpVCT) in der experimentellen osteoporosediagnostik am kleintiermodell

Translated title of the contribution: Feasibility of flat-panel volumetric computed tomography (fpVCT) in experimental small animal imaging of osteoporosis - Initial experience

R. Valencia, E. K. Stuermer, C. Dullin, K. P. Herrmann, I. Kluever, A. Zaroban, S. Sehmisch, M. Funke, Friedrich D Knollmann

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Background. Flat-panel volumetric computed tomography (fpVCT) is a new, noninvasive CT imaging modality with increased isotropic resolution. Technical details, potential applications, and our initial experience with a fpVCT prototype scanner in the imaging of osteoporosis in a rat model are presented. Methods. To date, 21 rats have been investigated in vivo with fpVCT. Pharmacologic effects on bone mineral density (BMD) and structure were of special interest. Image evaluation focussed on the second lumbar vertebra and the left femoral bone. To validate measurement results, BMD values calculated with fpVCT were correlated with results of BMD measurements from ashing of the second lumbar vertebra and femoral bones. Results. Our initial results show that fpVCT is capable of detecting differences in BMD between ovariectomized rats treated with estradiol and a control group with high statistical significance (p<0.05), corresponding to ashing as the gold standard. Conclusions. In a rat model, fpVCT imaging is especially useful in longitudinal in vivo investigations of BMD measures. Spatial resolution of up to 150 μm allows imaging of the trabecular structure only in human cadaveric bones.

Translated title of the contributionFeasibility of flat-panel volumetric computed tomography (fpVCT) in experimental small animal imaging of osteoporosis - Initial experience
Original languageGerman
Pages (from-to)893-900
Number of pages8
JournalRadiologe
Volume46
Issue number10
DOIs
StatePublished - Oct 2006
Externally publishedYes

Keywords

  • Bone mineral density
  • Computed tomography (CT)
  • Flat-panel volumetric computed tomography (fpVCT)
  • Osteoporosis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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    Valencia, R., Stuermer, E. K., Dullin, C., Herrmann, K. P., Kluever, I., Zaroban, A., Sehmisch, S., Funke, M., & Knollmann, F. D. (2006). Erste erfahrungen mit einem flächendetektor-volumen-CT (fpVCT) in der experimentellen osteoporosediagnostik am kleintiermodell. Radiologe, 46(10), 893-900. https://doi.org/10.1007/s00117-006-1390-7