Feasibility for using hypofractionated stereotactic volumetric modulated arc radiotherapy (vmat) with adaptive planning for treatment of thymoma in rabbits: 15 cases

Mario Dolera, Luca Malfassi, Giovanni Mazza, Gaetano Urso, Massimo Sala, Silvia Marcarini, Nancy Carrara, Simone Pavesi, Sara Finesso, Michael S Kent

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Thymoma is a relatively common tumor in rabbits. Treatment with surgery, radiation therapy, and chemotherapy alone or in combination has been reported with varying outcomes. Stereotactic volumetric modulated arc radiotherapy delivered in a hypofractionated manner allows high doses of radiation to be delivered to the target volume while allowing sparing of adjacent critical structures. This therapy is ideally suited for thymomas in rabbits given their size, the difficulty of multiple anesthesia episodes and the complexity of the radiotherapy plans required due to the tumor's proximity to the heart, lungs, and mediastinal structures. Fifteen rabbits with thymoma were prospectively recruited for this observational, single institution, single arm clinical study. All rabbits were imaged with both computed tomography (CT) and magnetic resonance imaging (MRI). A total dose of 40 Gy in six fractions was delivered using a single arc over an 11-day period with repeat CT simulation done every other fraction for adaptive planning. Follow-up evaluation was done through repeat CT and MRI imaging and revealed complete responses using the Response Evaluation Criteria in Solid Tumors (RECIST) criteria. Two rabbits had died at 618 and 718 days, 10 were alive and three were lost to follow-up. Observed acute and late effects were graded according to the Veterinary Radiation Therapy Oncology Group (VRTOG) criteria and were found to be minimal.

Original languageEnglish (US)
Pages (from-to)313-320
Number of pages8
JournalVeterinary Radiology and Ultrasound
Volume57
Issue number3
DOIs
StatePublished - May 1 2016

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thymoma
Thymoma
radiotherapy
Radiotherapy
planning
rabbits
Rabbits
computed tomography
Tomography
magnetic resonance imaging
neoplasms
Magnetic Resonance Imaging
Therapeutics
Radiation Oncology
Lost to Follow-Up
dosage
drug therapy
clinical trials
Neoplasms
anesthesia

Keywords

  • Rabbits
  • Radiation therapy
  • Stereotactic body radiotherapy
  • Thymoma
  • Veterinary
  • VMAT

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Feasibility for using hypofractionated stereotactic volumetric modulated arc radiotherapy (vmat) with adaptive planning for treatment of thymoma in rabbits : 15 cases. / Dolera, Mario; Malfassi, Luca; Mazza, Giovanni; Urso, Gaetano; Sala, Massimo; Marcarini, Silvia; Carrara, Nancy; Pavesi, Simone; Finesso, Sara; Kent, Michael S.

In: Veterinary Radiology and Ultrasound, Vol. 57, No. 3, 01.05.2016, p. 313-320.

Research output: Contribution to journalArticle

Dolera, Mario ; Malfassi, Luca ; Mazza, Giovanni ; Urso, Gaetano ; Sala, Massimo ; Marcarini, Silvia ; Carrara, Nancy ; Pavesi, Simone ; Finesso, Sara ; Kent, Michael S. / Feasibility for using hypofractionated stereotactic volumetric modulated arc radiotherapy (vmat) with adaptive planning for treatment of thymoma in rabbits : 15 cases. In: Veterinary Radiology and Ultrasound. 2016 ; Vol. 57, No. 3. pp. 313-320.
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