Fc receptor for IgG (FcR) on rat microglia

Christian Vedeler, Elling Ulvestad, Inger Grundt, Giancarlo Conti, Harald Nyland, Roald Matre, David E Pleasure

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Receptor for IgG (FcR) was demonstrated on rat microglia in vivo and in vitro by immunohistochemical staining with immune complexes of horseradish peroxidase (HRP) and rabbit IgG anti-HRP. Astrocytes, oligodendrocytes and neurons did not express FcR. Microglia in culture also showed FcR-mediated agglutination and phagocytosis of IgG-sensitized erythrocytes. A radiolabelled cDNA probe for rat FcRIII hybridized with a 1.4-kb RNA band in Northern blots prepared from total RNA from rat brain. FcRIII mRNA-positive cells in rat brain, presumably microglia, were demonstrated by in situ hybridization. FcR participates in the initiation of cytotoxic responses and of phagocytosis by microglia and is therefore likely to be important in mediating immune reactions in the brain.

Original languageEnglish (US)
Pages (from-to)19-24
Number of pages6
JournalJournal of Neuroimmunology
Volume49
Issue number1-2
DOIs
StatePublished - 1994
Externally publishedYes

Keywords

  • Fc receptor
  • Microglia
  • Rat

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

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  • Cite this

    Vedeler, C., Ulvestad, E., Grundt, I., Conti, G., Nyland, H., Matre, R., & Pleasure, D. E. (1994). Fc receptor for IgG (FcR) on rat microglia. Journal of Neuroimmunology, 49(1-2), 19-24. https://doi.org/10.1016/0165-5728(94)90176-7