Fc receptor for IgG (FcR) on rat microglia

Christian Vedeler; Elling Ulvestad; Inger Grundt; Giancarlo Conti; Harald Nyland; Roald Matre; David E Pleasure

doi:10.1016/0165-5728(94)90176-7

Fc receptor for IgG (FcR) on rat microglia

Christian Vedeler, Elling Ulvestad, Inger Grundt, Giancarlo Conti, Harald Nyland, Roald Matre, David E Pleasure

Research output: Contribution to journal › Article

54 Scopus citations

Abstract

Receptor for IgG (FcR) was demonstrated on rat microglia in vivo and in vitro by immunohistochemical staining with immune complexes of horseradish peroxidase (HRP) and rabbit IgG anti-HRP. Astrocytes, oligodendrocytes and neurons did not express FcR. Microglia in culture also showed FcR-mediated agglutination and phagocytosis of IgG-sensitized erythrocytes. A radiolabelled cDNA probe for rat FcRIII hybridized with a 1.4-kb RNA band in Northern blots prepared from total RNA from rat brain. FcRIII mRNA-positive cells in rat brain, presumably microglia, were demonstrated by in situ hybridization. FcR participates in the initiation of cytotoxic responses and of phagocytosis by microglia and is therefore likely to be important in mediating immune reactions in the brain.

Original language	English (US)
Pages (from-to)	19-24
Number of pages	6
Journal	Journal of Neuroimmunology
Volume	49
Issue number	1-2
DOIs	https://doi.org/10.1016/0165-5728(94)90176-7
State	Published - 1994
Externally published	Yes

Keywords

Fc receptor
Microglia
Rat

ASJC Scopus subject areas

Immunology
Immunology and Allergy
Clinical Neurology
Neurology

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Vedeler, C., Ulvestad, E., Grundt, I., Conti, G., Nyland, H., Matre, R., & Pleasure, D. E. (1994). Fc receptor for IgG (FcR) on rat microglia. Journal of Neuroimmunology, 49(1-2), 19-24. https://doi.org/10.1016/0165-5728(94)90176-7

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abstract = "Receptor for IgG (FcR) was demonstrated on rat microglia in vivo and in vitro by immunohistochemical staining with immune complexes of horseradish peroxidase (HRP) and rabbit IgG anti-HRP. Astrocytes, oligodendrocytes and neurons did not express FcR. Microglia in culture also showed FcR-mediated agglutination and phagocytosis of IgG-sensitized erythrocytes. A radiolabelled cDNA probe for rat FcRIII hybridized with a 1.4-kb RNA band in Northern blots prepared from total RNA from rat brain. FcRIII mRNA-positive cells in rat brain, presumably microglia, were demonstrated by in situ hybridization. FcR participates in the initiation of cytotoxic responses and of phagocytosis by microglia and is therefore likely to be important in mediating immune reactions in the brain.",

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AU - Vedeler, Christian

AU - Ulvestad, Elling

AU - Grundt, Inger

AU - Conti, Giancarlo

AU - Nyland, Harald

AU - Matre, Roald

AU - Pleasure, David E

PY - 1994

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AB - Receptor for IgG (FcR) was demonstrated on rat microglia in vivo and in vitro by immunohistochemical staining with immune complexes of horseradish peroxidase (HRP) and rabbit IgG anti-HRP. Astrocytes, oligodendrocytes and neurons did not express FcR. Microglia in culture also showed FcR-mediated agglutination and phagocytosis of IgG-sensitized erythrocytes. A radiolabelled cDNA probe for rat FcRIII hybridized with a 1.4-kb RNA band in Northern blots prepared from total RNA from rat brain. FcRIII mRNA-positive cells in rat brain, presumably microglia, were demonstrated by in situ hybridization. FcR participates in the initiation of cytotoxic responses and of phagocytosis by microglia and is therefore likely to be important in mediating immune reactions in the brain.

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