Fatty infiltration of liver in spontaneously ketotic dairy cows.

Y. Gröhn, L. A. Lindberg, M. L. Bruss, Thomas B Farver

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

The purpose of this study was to ascertain 1) fatty infiltration of the liver in spontaneously ketotic cows and 2) the most appropriate blood components to aid diagnosis of ketotic fatty liver. Liver biopsies and blood samples were obtained under field conditions. Cows were divided into three groups (healthy, mildly ketotic, and severely ketotic) by their blood ketone body concentrations. Severely ketotic cows had a greater percent fat in the liver than healthy cows. The mildly ketotic group fell between the other two groups and was significantly different from only the severely ketotic group. There was a positive correlation between fatty infiltration and blood ketone body concentrations but a negative correlation with glucose concentrations. Liver-specific enzymes were positively correlated with fatty infiltration. Only ornithine carbamoyltransferase and iditol (sorbitol) dehydrogenase could be used to separate healthy cows from those with severe ketosis. The best equation to explain the variation of percent fat in liver included concentration of beta-hydroxybutyrate (BHB) and logarithm of ornithine carbamoyltransferase concentration (Log-OCT): % Fat = -6.15 + 2.39 (BHB) + 11.7 (LogOCT) Although this equation explained 39.5% of the variation, it could not be used to predict reliably percent fat in the liver. Liver biopsy seems still to be the only reliable method of measuring of fatty infiltration in the liver.

Original languageEnglish (US)
Pages (from-to)2320-2328
Number of pages9
JournalJournal of Dairy Science
Volume66
Issue number11
StatePublished - Nov 1983

Fingerprint

Fatty Liver
dairy cows
liver
Liver
Fats
L-Iditol 2-Dehydrogenase
Ornithine Carbamoyltransferase
cows
ornithine carbamoyltransferase
Ketone Bodies
3-hydroxybutyric acid
3-Hydroxybutyric Acid
ketone bodies
blood
lipids
L-iditol dehydrogenase
biopsy
Biopsy
Ketosis
ketosis

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Food Science
  • veterinary(all)

Cite this

Gröhn, Y., Lindberg, L. A., Bruss, M. L., & Farver, T. B. (1983). Fatty infiltration of liver in spontaneously ketotic dairy cows. Journal of Dairy Science, 66(11), 2320-2328.

Fatty infiltration of liver in spontaneously ketotic dairy cows. / Gröhn, Y.; Lindberg, L. A.; Bruss, M. L.; Farver, Thomas B.

In: Journal of Dairy Science, Vol. 66, No. 11, 11.1983, p. 2320-2328.

Research output: Contribution to journalArticle

Gröhn, Y, Lindberg, LA, Bruss, ML & Farver, TB 1983, 'Fatty infiltration of liver in spontaneously ketotic dairy cows.', Journal of Dairy Science, vol. 66, no. 11, pp. 2320-2328.
Gröhn, Y. ; Lindberg, L. A. ; Bruss, M. L. ; Farver, Thomas B. / Fatty infiltration of liver in spontaneously ketotic dairy cows. In: Journal of Dairy Science. 1983 ; Vol. 66, No. 11. pp. 2320-2328.
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