Abstract
We compared the compositions of fatty acids including n-3, n-6 polyunsaturated fatty acids, trans- and cis-monounsaturated fatty acids, and saturated fatty acids in the red blood cell membranes of 40 children with autism (20 with early onset autism and 20 with developmental regression) and age-matched, 20 typically developing controls and 20 subjects with non-autistic developmental disabilities. The main findings include increased levels of eicosenoic acid (20:1n9) and erucic acid (22:1n9) in autistic subjects with developmental regression when compared with typically developing controls. In addition, an increase in 20:2n6 and a decrease in 16:1n7t were observed in children with clinical regression compared to those with early onset autism. Our results do not provide strong evidence for the hypothesis that abnormal fatty acid metabolism plays a role in the pathogenesis of autism spectrum disorder, although they suggest some metabolic or dietary abnormalities in the regressive form of autism.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 215-221 |
| Number of pages | 7 |
| Journal | Prostaglandins Leukotrienes and Essential Fatty Acids |
| Volume | 74 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 2006 |
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ASJC Scopus subject areas
- Clinical Biochemistry
- Endocrinology, Diabetes and Metabolism
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Fatty acid compositions of red blood cell phospholipids in children with autism. / Bu, B.; Ashwood, Paul; Harvey, Danielle J; King, I. B.; Van de Water, Judith A; Jin, Lee-Way.
In: Prostaglandins Leukotrienes and Essential Fatty Acids, Vol. 74, No. 4, 04.2006, p. 215-221.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fatty acid compositions of red blood cell phospholipids in children with autism
AU - Bu, B.
AU - Ashwood, Paul
AU - Harvey, Danielle J
AU - King, I. B.
AU - Van de Water, Judith A
AU - Jin, Lee-Way
PY - 2006/4
Y1 - 2006/4
N2 - We compared the compositions of fatty acids including n-3, n-6 polyunsaturated fatty acids, trans- and cis-monounsaturated fatty acids, and saturated fatty acids in the red blood cell membranes of 40 children with autism (20 with early onset autism and 20 with developmental regression) and age-matched, 20 typically developing controls and 20 subjects with non-autistic developmental disabilities. The main findings include increased levels of eicosenoic acid (20:1n9) and erucic acid (22:1n9) in autistic subjects with developmental regression when compared with typically developing controls. In addition, an increase in 20:2n6 and a decrease in 16:1n7t were observed in children with clinical regression compared to those with early onset autism. Our results do not provide strong evidence for the hypothesis that abnormal fatty acid metabolism plays a role in the pathogenesis of autism spectrum disorder, although they suggest some metabolic or dietary abnormalities in the regressive form of autism.
AB - We compared the compositions of fatty acids including n-3, n-6 polyunsaturated fatty acids, trans- and cis-monounsaturated fatty acids, and saturated fatty acids in the red blood cell membranes of 40 children with autism (20 with early onset autism and 20 with developmental regression) and age-matched, 20 typically developing controls and 20 subjects with non-autistic developmental disabilities. The main findings include increased levels of eicosenoic acid (20:1n9) and erucic acid (22:1n9) in autistic subjects with developmental regression when compared with typically developing controls. In addition, an increase in 20:2n6 and a decrease in 16:1n7t were observed in children with clinical regression compared to those with early onset autism. Our results do not provide strong evidence for the hypothesis that abnormal fatty acid metabolism plays a role in the pathogenesis of autism spectrum disorder, although they suggest some metabolic or dietary abnormalities in the regressive form of autism.
UR - http://www.scopus.com/inward/record.url?scp=33646491403&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646491403&partnerID=8YFLogxK
U2 - 10.1016/j.plefa.2006.02.001
DO - 10.1016/j.plefa.2006.02.001
M3 - Article
C2 - 16581239
AN - SCOPUS:33646491403
VL - 74
SP - 215
EP - 221
JO - Prostaglandins Leukotrienes and Essential Fatty Acids
JF - Prostaglandins Leukotrienes and Essential Fatty Acids
SN - 0952-3278
IS - 4
ER -