Fatty acid composition of macrophage phospholipids in mice fed fish or borage oil

Robert S. Chapkin, Scott D. Somers, Leslie Schumacher, Kent L Erickson

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The polyunsaturated fatty acid (PUFA) composition of murine peritoneal macrophage phospholipids was dramatically altered in vivo following the four-wk feeding of specific dietary oils. Fish oil (containing 20:5n-3 and 22:6n-3) feeding significantly increased macrophage 20:5n-3, 22:5n-3, and 22:6n-3 (P<0.05), while borage oil (containing 18:2n-6 and 18:3n-6) increased (P<0.05) the macrophage 20:3n-6/20:4n-6 ratio, relative to safflower oil (containing 18:2n-6) and hydrogenated coconut oil (containing 12:0)-fed animals. The macrophage phospholipid PUFA profiles were compared with those of the liver, lung and spleen. The significance of the PUFA alterations is discussed.

Original languageEnglish (US)
Pages (from-to)380-383
Number of pages4
JournalLipids
Volume23
Issue number4
DOIs
StatePublished - Apr 1988

Fingerprint

borage oil
Fish Oils
Macrophages
Unsaturated Fatty Acids
fish oils
Phospholipids
phospholipids
macrophages
Fatty Acids
fatty acid composition
polyunsaturated fatty acids
mice
Chemical analysis
Safflower Oil
Unsaturated Dietary Fats
Peritoneal Macrophages
safflower oil
hydrogenated oils
coconut oil
Spleen

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Food Science

Cite this

Fatty acid composition of macrophage phospholipids in mice fed fish or borage oil. / Chapkin, Robert S.; Somers, Scott D.; Schumacher, Leslie; Erickson, Kent L.

In: Lipids, Vol. 23, No. 4, 04.1988, p. 380-383.

Research output: Contribution to journalArticle

Chapkin, Robert S. ; Somers, Scott D. ; Schumacher, Leslie ; Erickson, Kent L. / Fatty acid composition of macrophage phospholipids in mice fed fish or borage oil. In: Lipids. 1988 ; Vol. 23, No. 4. pp. 380-383.
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