Fatty acid composition of macrophage phospholipids in mice fed fish or borage oil

Robert S. Chapkin, Scott D. Somers, Leslie Schumacher, Kent L Erickson

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

The polyunsaturated fatty acid (PUFA) composition of murine peritoneal macrophage phospholipids was dramatically altered in vivo following the four-wk feeding of specific dietary oils. Fish oil (containing 20:5n-3 and 22:6n-3) feeding significantly increased macrophage 20:5n-3, 22:5n-3, and 22:6n-3 (P<0.05), while borage oil (containing 18:2n-6 and 18:3n-6) increased (P<0.05) the macrophage 20:3n-6/20:4n-6 ratio, relative to safflower oil (containing 18:2n-6) and hydrogenated coconut oil (containing 12:0)-fed animals. The macrophage phospholipid PUFA profiles were compared with those of the liver, lung and spleen. The significance of the PUFA alterations is discussed.

Original languageEnglish (US)
Pages (from-to)380-383
Number of pages4
JournalLipids
Volume23
Issue number4
DOIs
StatePublished - Apr 1988

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Food Science

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