Abstract
The polyunsaturated fatty acid (PUFA) composition of murine peritoneal macrophage phospholipids was dramatically altered in vivo following the four-wk feeding of specific dietary oils. Fish oil (containing 20:5n-3 and 22:6n-3) feeding significantly increased macrophage 20:5n-3, 22:5n-3, and 22:6n-3 (P<0.05), while borage oil (containing 18:2n-6 and 18:3n-6) increased (P<0.05) the macrophage 20:3n-6/20:4n-6 ratio, relative to safflower oil (containing 18:2n-6) and hydrogenated coconut oil (containing 12:0)-fed animals. The macrophage phospholipid PUFA profiles were compared with those of the liver, lung and spleen. The significance of the PUFA alterations is discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 380-383 |
| Number of pages | 4 |
| Journal | Lipids |
| Volume | 23 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1988 |
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Biochemistry
- Biochemistry, Genetics and Molecular Biology(all)
- Food Science
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Chapkin, R. S., Somers, S. D., Schumacher, L., & Erickson, K. L. (1988). Fatty acid composition of macrophage phospholipids in mice fed fish or borage oil. Lipids, 23(4), 380-383. https://doi.org/10.1007/BF02537356