Fatty acid composition of macrophage phospholipids in mice fed fish or borage oil

Robert S. Chapkin; Scott D. Somers; Leslie Schumacher; Kent L Erickson

doi:10.1007/BF02537356

Fatty acid composition of macrophage phospholipids in mice fed fish or borage oil

Robert S. Chapkin, Scott D. Somers, Leslie Schumacher, Kent L Erickson

Cell Biology and Human Anatomy

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

The polyunsaturated fatty acid (PUFA) composition of murine peritoneal macrophage phospholipids was dramatically altered in vivo following the four-wk feeding of specific dietary oils. Fish oil (containing 20:5n-3 and 22:6n-3) feeding significantly increased macrophage 20:5n-3, 22:5n-3, and 22:6n-3 (P<0.05), while borage oil (containing 18:2n-6 and 18:3n-6) increased (P<0.05) the macrophage 20:3n-6/20:4n-6 ratio, relative to safflower oil (containing 18:2n-6) and hydrogenated coconut oil (containing 12:0)-fed animals. The macrophage phospholipid PUFA profiles were compared with those of the liver, lung and spleen. The significance of the PUFA alterations is discussed.

Original language	English (US)
Pages (from-to)	380-383
Number of pages	4
Journal	Lipids
Volume	23
Issue number	4
DOIs	https://doi.org/10.1007/BF02537356
State	Published - Apr 1988

ASJC Scopus subject areas

Medicine (miscellaneous)
Biochemistry
Biochemistry, Genetics and Molecular Biology(all)
Food Science

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title = "Fatty acid composition of macrophage phospholipids in mice fed fish or borage oil",

abstract = "The polyunsaturated fatty acid (PUFA) composition of murine peritoneal macrophage phospholipids was dramatically altered in vivo following the four-wk feeding of specific dietary oils. Fish oil (containing 20:5n-3 and 22:6n-3) feeding significantly increased macrophage 20:5n-3, 22:5n-3, and 22:6n-3 (P<0.05), while borage oil (containing 18:2n-6 and 18:3n-6) increased (P<0.05) the macrophage 20:3n-6/20:4n-6 ratio, relative to safflower oil (containing 18:2n-6) and hydrogenated coconut oil (containing 12:0)-fed animals. The macrophage phospholipid PUFA profiles were compared with those of the liver, lung and spleen. The significance of the PUFA alterations is discussed.",

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AU - Chapkin, Robert S.

AU - Somers, Scott D.

AU - Schumacher, Leslie

AU - Erickson, Kent L

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N2 - The polyunsaturated fatty acid (PUFA) composition of murine peritoneal macrophage phospholipids was dramatically altered in vivo following the four-wk feeding of specific dietary oils. Fish oil (containing 20:5n-3 and 22:6n-3) feeding significantly increased macrophage 20:5n-3, 22:5n-3, and 22:6n-3 (P<0.05), while borage oil (containing 18:2n-6 and 18:3n-6) increased (P<0.05) the macrophage 20:3n-6/20:4n-6 ratio, relative to safflower oil (containing 18:2n-6) and hydrogenated coconut oil (containing 12:0)-fed animals. The macrophage phospholipid PUFA profiles were compared with those of the liver, lung and spleen. The significance of the PUFA alterations is discussed.

AB - The polyunsaturated fatty acid (PUFA) composition of murine peritoneal macrophage phospholipids was dramatically altered in vivo following the four-wk feeding of specific dietary oils. Fish oil (containing 20:5n-3 and 22:6n-3) feeding significantly increased macrophage 20:5n-3, 22:5n-3, and 22:6n-3 (P<0.05), while borage oil (containing 18:2n-6 and 18:3n-6) increased (P<0.05) the macrophage 20:3n-6/20:4n-6 ratio, relative to safflower oil (containing 18:2n-6) and hydrogenated coconut oil (containing 12:0)-fed animals. The macrophage phospholipid PUFA profiles were compared with those of the liver, lung and spleen. The significance of the PUFA alterations is discussed.

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