Fate of ultrahigh molecular weight polyethylene (UHMW-PE) wear debris in patients with hip implants

H. Witkiewicz, Tamas J Vidovszky, R. T. Turner, M. G. Rock, B. F. Morrey, M. E. Bolander

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The process of ultrahigh molecular weight polyethylene (UHMW-PE) breakdown, started at the articular surface of the cup, continues in small fragments after generation. An assiduous interaction between the UHMW-PE particles and the host cells leads to oxidative changes of the UHMW-PE and to size reduction of the particles simultaneous with transporting them toward, and finally by, lymphatic or blood vessels. The particles are mobilized by means of enzymatic, extracellular matrix-degrading activity of cells that have phagocytosed them or adhered to them. Together, these characteristics indicate an attempt by the natural cellular immunity system to eliminate the implant wear debris. Macrophages are the main effector cells acting as scavengers; however, excessive amount of the wear debris evokes phagocytic activity of cells other than macrophages as well.

Original languageEnglish (US)
Pages (from-to)254-261
Number of pages8
JournalTechniques in Orthopaedics
Volume8
Issue number4
DOIs
StatePublished - 1993
Externally publishedYes

Fingerprint

Hip
Macrophages
Cytophagocytosis
Lymphatic Vessels
Phagocytes
Particle Size
Innate Immunity
Cellular Immunity
Extracellular Matrix
Blood Vessels
Joints
ultra-high molecular weight polyethylene

Keywords

  • Ultrahigh molecular weight polyethylene

ASJC Scopus subject areas

  • Surgery

Cite this

Fate of ultrahigh molecular weight polyethylene (UHMW-PE) wear debris in patients with hip implants. / Witkiewicz, H.; Vidovszky, Tamas J; Turner, R. T.; Rock, M. G.; Morrey, B. F.; Bolander, M. E.

In: Techniques in Orthopaedics, Vol. 8, No. 4, 1993, p. 254-261.

Research output: Contribution to journalArticle

Witkiewicz, H. ; Vidovszky, Tamas J ; Turner, R. T. ; Rock, M. G. ; Morrey, B. F. ; Bolander, M. E. / Fate of ultrahigh molecular weight polyethylene (UHMW-PE) wear debris in patients with hip implants. In: Techniques in Orthopaedics. 1993 ; Vol. 8, No. 4. pp. 254-261.
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