Abstract
Progressive, sustained bradycardia resulting in asystole and subsequent death is reported in a 70-year-old woman with hyperkalemia and suspected digoxin toxicity following a 0.25 mg/kg intravenous diltiazem dose for treatment of atrial fibrillation with a rapid ventricular response. The possible pharmacodynamic and pharmacokinetic interactions between diltiazem, digoxin, and an elevated plasma potassium concentration are discussed and related to the outcome of the case. The routine practice of concomitant administration of diltiazem for rapid ventricular rate control and digoxin for long-term control may be dangerous in a subset of patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 306-310 |
| Number of pages | 5 |
| Journal | Pharmacotherapy |
| Volume | 16 |
| Issue number | 2 I |
| State | Published - 1996 |
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ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)
Cite this
Fatality due to intravenous diltiazem for acute ventricular rate control. / Moser, Lynette R.; Panacek, Edward A; Munger, Mark A.
In: Pharmacotherapy, Vol. 16, No. 2 I, 1996, p. 306-310.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fatality due to intravenous diltiazem for acute ventricular rate control
AU - Moser, Lynette R.
AU - Panacek, Edward A
AU - Munger, Mark A.
PY - 1996
Y1 - 1996
N2 - Progressive, sustained bradycardia resulting in asystole and subsequent death is reported in a 70-year-old woman with hyperkalemia and suspected digoxin toxicity following a 0.25 mg/kg intravenous diltiazem dose for treatment of atrial fibrillation with a rapid ventricular response. The possible pharmacodynamic and pharmacokinetic interactions between diltiazem, digoxin, and an elevated plasma potassium concentration are discussed and related to the outcome of the case. The routine practice of concomitant administration of diltiazem for rapid ventricular rate control and digoxin for long-term control may be dangerous in a subset of patients.
AB - Progressive, sustained bradycardia resulting in asystole and subsequent death is reported in a 70-year-old woman with hyperkalemia and suspected digoxin toxicity following a 0.25 mg/kg intravenous diltiazem dose for treatment of atrial fibrillation with a rapid ventricular response. The possible pharmacodynamic and pharmacokinetic interactions between diltiazem, digoxin, and an elevated plasma potassium concentration are discussed and related to the outcome of the case. The routine practice of concomitant administration of diltiazem for rapid ventricular rate control and digoxin for long-term control may be dangerous in a subset of patients.
UR - http://www.scopus.com/inward/record.url?scp=0029869106&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029869106&partnerID=8YFLogxK
M3 - Article
VL - 16
SP - 306
EP - 310
JO - Pharmacotherapy
JF - Pharmacotherapy
SN - 0277-0008
IS - 2 I
ER -