Abstract
Introduction: We report a case of a 61-year-old woman with locally destructive vulvar pyoderma gangrenosum (PG) with pulmonary involvement who was refractory to numerous systemic therapies and developed complications resulting in her demise. Objective: To report a rare case of treatment-resistant vulvar PG with pulmonary involvement that proved to be fatal. Methods: PubMed was used to search for other reports that discuss PG, or more specifically perigenital PG, with pulmonary involvement. Results and Conclusion: A thorough review of the literature revealed 33 cases of PG with pulmonary involvement, with only 4 involving the perigenital region. We report the second case of a female with vulvar PG and pulmonary involvement. In contrast to the first case described, our patient did not respond to systemic therapy, and, ultimately, her disease was fatal. It is hoped that with continued documentation of this rare and potentially lethal presentation of PG, physicians will determine more effective treatments.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 424-429 |
| Number of pages | 6 |
| Journal | Journal of Cutaneous Medicine and Surgery |
| Volume | 18 |
| Issue number | 6 |
| DOIs | |
| State | Published - Nov 1 2014 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Surgery
- Dermatology
Cite this
Fatal case of vulvar pyoderma gangrenosum with pulmonary involvement : Case presentation and literature review. / Mercer, Joshua M.; Kuzel, Paul; Mahmood, Muhammad N.; Brassard, Alain.
In: Journal of Cutaneous Medicine and Surgery, Vol. 18, No. 6, 01.11.2014, p. 424-429.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Fatal case of vulvar pyoderma gangrenosum with pulmonary involvement
T2 - Case presentation and literature review
AU - Mercer, Joshua M.
AU - Kuzel, Paul
AU - Mahmood, Muhammad N.
AU - Brassard, Alain
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Introduction: We report a case of a 61-year-old woman with locally destructive vulvar pyoderma gangrenosum (PG) with pulmonary involvement who was refractory to numerous systemic therapies and developed complications resulting in her demise. Objective: To report a rare case of treatment-resistant vulvar PG with pulmonary involvement that proved to be fatal. Methods: PubMed was used to search for other reports that discuss PG, or more specifically perigenital PG, with pulmonary involvement. Results and Conclusion: A thorough review of the literature revealed 33 cases of PG with pulmonary involvement, with only 4 involving the perigenital region. We report the second case of a female with vulvar PG and pulmonary involvement. In contrast to the first case described, our patient did not respond to systemic therapy, and, ultimately, her disease was fatal. It is hoped that with continued documentation of this rare and potentially lethal presentation of PG, physicians will determine more effective treatments.
AB - Introduction: We report a case of a 61-year-old woman with locally destructive vulvar pyoderma gangrenosum (PG) with pulmonary involvement who was refractory to numerous systemic therapies and developed complications resulting in her demise. Objective: To report a rare case of treatment-resistant vulvar PG with pulmonary involvement that proved to be fatal. Methods: PubMed was used to search for other reports that discuss PG, or more specifically perigenital PG, with pulmonary involvement. Results and Conclusion: A thorough review of the literature revealed 33 cases of PG with pulmonary involvement, with only 4 involving the perigenital region. We report the second case of a female with vulvar PG and pulmonary involvement. In contrast to the first case described, our patient did not respond to systemic therapy, and, ultimately, her disease was fatal. It is hoped that with continued documentation of this rare and potentially lethal presentation of PG, physicians will determine more effective treatments.
UR - http://www.scopus.com/inward/record.url?scp=84908882897&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84908882897&partnerID=8YFLogxK
U2 - 10.2310/7750.2014.13196
DO - 10.2310/7750.2014.13196
M3 - Review article
C2 - 25348765
AN - SCOPUS:84908882897
VL - 18
SP - 424
EP - 429
JO - Journal of Cutaneous Medicine and Surgery
JF - Journal of Cutaneous Medicine and Surgery
SN - 1203-4754
IS - 6
ER -