Fatal bronchopneumonia caused by skunk adenovirus 1 in an African pygmy hedgehog

David B. Needle, Martin K. Selig, Kenneth A. Jackson, Eric Delwart, Ellyn Tighe, Stephen L. Leib, Torsten Seuberlich, Patricia Pesavento

Research output: Contribution to journalArticle

Abstract

Eleven adult African pygmy hedgehogs (Atelerix albiventris) were added to a group of 35 animals, and within 10 d, respiratory distress affected 8 of 35 resident animals in the group, but none of the introduced animals. Three animals died following onset of clinical signs. Tissues from one animal were collected and submitted for histopathology, which revealed acute necrotizing bronchopneumonia and tracheitis with intraepithelial intranuclear inclusion bodies. Electron microscopy identified 75–90 nm diameter encapsulated icosahedral virions. Degenerate nested PCR analysis identified adenovirus within the affected lung tissue. Deep sequencing showed 100% homology to skunk adenovirus 1 (SkAdV-1). Adenoviruses are usually species-adapted and -specific, but our case supports the single previous report of non-skunk infection with SkAdV-1, indicating that this virus can infect other species, and further shows that it can cause fatal disease.

Original languageEnglish (US)
Pages (from-to)103-106
Number of pages4
JournalJournal of Veterinary Diagnostic Investigation
Volume31
Issue number1
DOIs
StatePublished - Jan 1 2019

Fingerprint

Mephitidae
skunks
Bronchopneumonia
bronchopneumonia
Hedgehogs
Erinaceidae
Adenoviridae
animals
Atelerix albiventris
Tracheitis
nuclear inclusions
tracheitis
Intranuclear Inclusion Bodies
High-Throughput Nucleotide Sequencing
distress
virion
Virion
histopathology
electron microscopy
Electron Microscopy

Keywords

  • Atelerix albiventris
  • Adenoviridae
  • African pygmy hedgehogs
  • bronchopneumonia, lung
  • PCR
  • skunk adenovirus 1
  • transmission electron microscopy

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Fatal bronchopneumonia caused by skunk adenovirus 1 in an African pygmy hedgehog. / Needle, David B.; Selig, Martin K.; Jackson, Kenneth A.; Delwart, Eric; Tighe, Ellyn; Leib, Stephen L.; Seuberlich, Torsten; Pesavento, Patricia.

In: Journal of Veterinary Diagnostic Investigation, Vol. 31, No. 1, 01.01.2019, p. 103-106.

Research output: Contribution to journalArticle

Needle, DB, Selig, MK, Jackson, KA, Delwart, E, Tighe, E, Leib, SL, Seuberlich, T & Pesavento, P 2019, 'Fatal bronchopneumonia caused by skunk adenovirus 1 in an African pygmy hedgehog', Journal of Veterinary Diagnostic Investigation, vol. 31, no. 1, pp. 103-106. https://doi.org/10.1177/1040638718812123
Needle, David B. ; Selig, Martin K. ; Jackson, Kenneth A. ; Delwart, Eric ; Tighe, Ellyn ; Leib, Stephen L. ; Seuberlich, Torsten ; Pesavento, Patricia. / Fatal bronchopneumonia caused by skunk adenovirus 1 in an African pygmy hedgehog. In: Journal of Veterinary Diagnostic Investigation. 2019 ; Vol. 31, No. 1. pp. 103-106.
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