Abstract
A 54-year-old man with advanced non-Hodgkin's lymphoma and chronic renal insufficiency was treated with combination chemotherapy which included bleomycin. Fatal pulmonary toxicity developed after administration of a total bleomycin dose of only 60 U. Transbronchial biopsy and autopsy demonstrated pathologic findings consistent with bleomycin-induced pulmonary fibrosis. High-dose corticosteroid therapy did not appear to alter the clinical course. Extreme caution should be exercised when administering bleomycin to patients with renal insufficiency.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2617-2620 |
| Number of pages | 4 |
| Journal | Cancer |
| Volume | 60 |
| Issue number | 11 |
| State | Published - 1987 |
ASJC Scopus subject areas
- Cancer Research
- Oncology
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McLeod, B. F., Lawrence, H. J., Smith, D. W., Vogt, P. J., & Gandara, D. R. (1987). Fatal bleomycin toxicity from a low cumulative dose in a patient with renal insufficiency. Cancer, 60(11), 2617-2620.