Fatal bleomycin toxicity from a low cumulative dose in a patient with renal insufficiency

B. F. McLeod; H. J. Lawrence; D. W. Smith; P. J. Vogt; D. R. Gandara

Fatal bleomycin toxicity from a low cumulative dose in a patient with renal insufficiency

B. F. McLeod, H. J. Lawrence, D. W. Smith, P. J. Vogt, D. R. Gandara

Hematology and Oncology

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

A 54-year-old man with advanced non-Hodgkin's lymphoma and chronic renal insufficiency was treated with combination chemotherapy which included bleomycin. Fatal pulmonary toxicity developed after administration of a total bleomycin dose of only 60 U. Transbronchial biopsy and autopsy demonstrated pathologic findings consistent with bleomycin-induced pulmonary fibrosis. High-dose corticosteroid therapy did not appear to alter the clinical course. Extreme caution should be exercised when administering bleomycin to patients with renal insufficiency.

Original language	English (US)
Pages (from-to)	2617-2620
Number of pages	4
Journal	Cancer
Volume	60
Issue number	11
State	Published - 1987

ASJC Scopus subject areas

Cancer Research
Oncology

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abstract = "A 54-year-old man with advanced non-Hodgkin's lymphoma and chronic renal insufficiency was treated with combination chemotherapy which included bleomycin. Fatal pulmonary toxicity developed after administration of a total bleomycin dose of only 60 U. Transbronchial biopsy and autopsy demonstrated pathologic findings consistent with bleomycin-induced pulmonary fibrosis. High-dose corticosteroid therapy did not appear to alter the clinical course. Extreme caution should be exercised when administering bleomycin to patients with renal insufficiency.",

author = "McLeod, {B. F.} and Lawrence, {H. J.} and Smith, {D. W.} and Vogt, {P. J.} and Gandara, {D. R.}",

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AU - Vogt, P. J.

AU - Gandara, D. R.

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N2 - A 54-year-old man with advanced non-Hodgkin's lymphoma and chronic renal insufficiency was treated with combination chemotherapy which included bleomycin. Fatal pulmonary toxicity developed after administration of a total bleomycin dose of only 60 U. Transbronchial biopsy and autopsy demonstrated pathologic findings consistent with bleomycin-induced pulmonary fibrosis. High-dose corticosteroid therapy did not appear to alter the clinical course. Extreme caution should be exercised when administering bleomycin to patients with renal insufficiency.

AB - A 54-year-old man with advanced non-Hodgkin's lymphoma and chronic renal insufficiency was treated with combination chemotherapy which included bleomycin. Fatal pulmonary toxicity developed after administration of a total bleomycin dose of only 60 U. Transbronchial biopsy and autopsy demonstrated pathologic findings consistent with bleomycin-induced pulmonary fibrosis. High-dose corticosteroid therapy did not appear to alter the clinical course. Extreme caution should be exercised when administering bleomycin to patients with renal insufficiency.

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