Fatal acute meningoencephalitis due to lymphocytic choriomeningitis virus

Raphael L. Warkel, Charles F. Rinaldi, William H. Bancroft, Robert Cardiff, George E. Holmes, Roger E. Wilsnack

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Although lymphocytic choriomeningitis virus usually produces a benign aseptic meningitis and rarely causes death, a fatal case of acute meningoencephalitis due to LCM occurred in a 19 year old girl. The principal histologic manifestations were lymphocytic and monocytic infiltrates in the meninges and Virchow-Robin spaces and focal inflammatory nodules in the pons and medulla. The virus was isolated from the patient’s brain and complement-fixing and neutralizing antibodies were detected in the serum. Immunofluorescence studies showed viral antigen in the meninges and in the cytoplasm of the cerebral neurons.

Original languageEnglish (US)
Pages (from-to)198-203
Number of pages6
JournalNeurology
Volume23
Issue number2
StatePublished - Jan 1 1973
Externally publishedYes

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Lymphocytic choriomeningitis virus
Meninges
Meningoencephalitis
Aseptic Meningitis
Songbirds
Pons
Viral Antigens
Neutralizing Antibodies
Fluorescent Antibody Technique
Cause of Death
Cytoplasm
Viruses
Neurons
Brain
Serum

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Warkel, R. L., Rinaldi, C. F., Bancroft, W. H., Cardiff, R., Holmes, G. E., & Wilsnack, R. E. (1973). Fatal acute meningoencephalitis due to lymphocytic choriomeningitis virus. Neurology, 23(2), 198-203.

Fatal acute meningoencephalitis due to lymphocytic choriomeningitis virus. / Warkel, Raphael L.; Rinaldi, Charles F.; Bancroft, William H.; Cardiff, Robert; Holmes, George E.; Wilsnack, Roger E.

In: Neurology, Vol. 23, No. 2, 01.01.1973, p. 198-203.

Research output: Contribution to journalArticle

Warkel, RL, Rinaldi, CF, Bancroft, WH, Cardiff, R, Holmes, GE & Wilsnack, RE 1973, 'Fatal acute meningoencephalitis due to lymphocytic choriomeningitis virus', Neurology, vol. 23, no. 2, pp. 198-203.
Warkel RL, Rinaldi CF, Bancroft WH, Cardiff R, Holmes GE, Wilsnack RE. Fatal acute meningoencephalitis due to lymphocytic choriomeningitis virus. Neurology. 1973 Jan 1;23(2):198-203.
Warkel, Raphael L. ; Rinaldi, Charles F. ; Bancroft, William H. ; Cardiff, Robert ; Holmes, George E. ; Wilsnack, Roger E. / Fatal acute meningoencephalitis due to lymphocytic choriomeningitis virus. In: Neurology. 1973 ; Vol. 23, No. 2. pp. 198-203.
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