Fatal acute meningoencephalitis due to lymphocytic choriomeningitis virus

Raphael L. Warkel, Charles F. Rinaldi, William H. Bancroft, Robert Cardiff, George E. Holmes, Roger E. Wilsnack

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Although lymphocytic choriomeningitis virus usually produces a benign aseptic meningitis and rarely causes death, a fatal case of acute meningoencephalitis due to LCM occurred in a 19 year old girl. The principal histologic manifestations were lymphocytic and monocytic infiltrates in the meninges and Virchow-Robin spaces and focal inflammatory nodules in the pons and medulla. The virus was isolated from the patient’s brain and complement-fixing and neutralizing antibodies were detected in the serum. Immunofluorescence studies showed viral antigen in the meninges and in the cytoplasm of the cerebral neurons.

Original languageEnglish (US)
Pages (from-to)198-203
Number of pages6
Issue number2
StatePublished - Jan 1 1973
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology


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