Abstract
Although lymphocytic choriomeningitis virus usually produces a benign aseptic meningitis and rarely causes death, a fatal case of acute meningoencephalitis due to LCM occurred in a 19 year old girl. The principal histologic manifestations were lymphocytic and monocytic infiltrates in the meninges and Virchow-Robin spaces and focal inflammatory nodules in the pons and medulla. The virus was isolated from the patient’s brain and complement-fixing and neutralizing antibodies were detected in the serum. Immunofluorescence studies showed viral antigen in the meninges and in the cytoplasm of the cerebral neurons.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 198-203 |
| Number of pages | 6 |
| Journal | Neurology |
| Volume | 23 |
| Issue number | 2 |
| State | Published - Jan 1 1973 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Clinical Neurology
Cite this
Fatal acute meningoencephalitis due to lymphocytic choriomeningitis virus. / Warkel, Raphael L.; Rinaldi, Charles F.; Bancroft, William H.; Cardiff, Robert; Holmes, George E.; Wilsnack, Roger E.
In: Neurology, Vol. 23, No. 2, 01.01.1973, p. 198-203.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fatal acute meningoencephalitis due to lymphocytic choriomeningitis virus
AU - Warkel, Raphael L.
AU - Rinaldi, Charles F.
AU - Bancroft, William H.
AU - Cardiff, Robert
AU - Holmes, George E.
AU - Wilsnack, Roger E.
PY - 1973/1/1
Y1 - 1973/1/1
N2 - Although lymphocytic choriomeningitis virus usually produces a benign aseptic meningitis and rarely causes death, a fatal case of acute meningoencephalitis due to LCM occurred in a 19 year old girl. The principal histologic manifestations were lymphocytic and monocytic infiltrates in the meninges and Virchow-Robin spaces and focal inflammatory nodules in the pons and medulla. The virus was isolated from the patient’s brain and complement-fixing and neutralizing antibodies were detected in the serum. Immunofluorescence studies showed viral antigen in the meninges and in the cytoplasm of the cerebral neurons.
AB - Although lymphocytic choriomeningitis virus usually produces a benign aseptic meningitis and rarely causes death, a fatal case of acute meningoencephalitis due to LCM occurred in a 19 year old girl. The principal histologic manifestations were lymphocytic and monocytic infiltrates in the meninges and Virchow-Robin spaces and focal inflammatory nodules in the pons and medulla. The virus was isolated from the patient’s brain and complement-fixing and neutralizing antibodies were detected in the serum. Immunofluorescence studies showed viral antigen in the meninges and in the cytoplasm of the cerebral neurons.
UR - http://www.scopus.com/inward/record.url?scp=0015576428&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0015576428&partnerID=8YFLogxK
M3 - Article
C2 - 4568992
AN - SCOPUS:0015576428
VL - 23
SP - 198
EP - 203
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 2
ER -