Fatal acute meningoencephalitis due to lymphocytic choriomeningitis virus

Raphael L. Warkel; Charles F. Rinaldi; William H. Bancroft; Robert Cardiff; George E. Holmes; Roger E. Wilsnack

Fatal acute meningoencephalitis due to lymphocytic choriomeningitis virus

Raphael L. Warkel, Charles F. Rinaldi, William H. Bancroft, Robert Cardiff, George E. Holmes, Roger E. Wilsnack

Research output: Contribution to journal › Article › peer-review

Abstract

Although lymphocytic choriomeningitis virus usually produces a benign aseptic meningitis and rarely causes death, a fatal case of acute meningoencephalitis due to LCM occurred in a 19 year old girl. The principal histologic manifestations were lymphocytic and monocytic infiltrates in the meninges and Virchow-Robin spaces and focal inflammatory nodules in the pons and medulla. The virus was isolated from the patient’s brain and complement-fixing and neutralizing antibodies were detected in the serum. Immunofluorescence studies showed viral antigen in the meninges and in the cytoplasm of the cerebral neurons.

Original language	English (US)
Pages (from-to)	198-203
Number of pages	6
Journal	Neurology
Volume	23
Issue number	2
State	Published - Jan 1 1973
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology

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@article{32f833b9a4bd4e3f850253fd4ab5662c,

title = "Fatal acute meningoencephalitis due to lymphocytic choriomeningitis virus",

abstract = "Although lymphocytic choriomeningitis virus usually produces a benign aseptic meningitis and rarely causes death, a fatal case of acute meningoencephalitis due to LCM occurred in a 19 year old girl. The principal histologic manifestations were lymphocytic and monocytic infiltrates in the meninges and Virchow-Robin spaces and focal inflammatory nodules in the pons and medulla. The virus was isolated from the patient{\textquoteright}s brain and complement-fixing and neutralizing antibodies were detected in the serum. Immunofluorescence studies showed viral antigen in the meninges and in the cytoplasm of the cerebral neurons.",

author = "Warkel, {Raphael L.} and Rinaldi, {Charles F.} and Bancroft, {William H.} and Robert Cardiff and Holmes, {George E.} and Wilsnack, {Roger E.}",

year = "1973",

month = jan,

day = "1",

language = "English (US)",

volume = "23",

pages = "198--203",

journal = "Neurology",

issn = "0028-3878",

publisher = "Lippincott Williams and Wilkins",

number = "2",

}

TY - JOUR

T1 - Fatal acute meningoencephalitis due to lymphocytic choriomeningitis virus

AU - Warkel, Raphael L.

AU - Rinaldi, Charles F.

AU - Bancroft, William H.

AU - Cardiff, Robert

AU - Holmes, George E.

AU - Wilsnack, Roger E.

PY - 1973/1/1

Y1 - 1973/1/1

N2 - Although lymphocytic choriomeningitis virus usually produces a benign aseptic meningitis and rarely causes death, a fatal case of acute meningoencephalitis due to LCM occurred in a 19 year old girl. The principal histologic manifestations were lymphocytic and monocytic infiltrates in the meninges and Virchow-Robin spaces and focal inflammatory nodules in the pons and medulla. The virus was isolated from the patient’s brain and complement-fixing and neutralizing antibodies were detected in the serum. Immunofluorescence studies showed viral antigen in the meninges and in the cytoplasm of the cerebral neurons.

AB - Although lymphocytic choriomeningitis virus usually produces a benign aseptic meningitis and rarely causes death, a fatal case of acute meningoencephalitis due to LCM occurred in a 19 year old girl. The principal histologic manifestations were lymphocytic and monocytic infiltrates in the meninges and Virchow-Robin spaces and focal inflammatory nodules in the pons and medulla. The virus was isolated from the patient’s brain and complement-fixing and neutralizing antibodies were detected in the serum. Immunofluorescence studies showed viral antigen in the meninges and in the cytoplasm of the cerebral neurons.

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M3 - Article

C2 - 4568992

AN - SCOPUS:0015576428

VL - 23

SP - 198

EP - 203

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 2

ER -