Fast iterative image reconstruction methods for fully 3D multispectral bioluminescence tomography

Sangtae Ahn, Abhijit Chaudhari, Felix Darvas, Charles A. Bouman, Richard M. Leahy

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

We investigate fast iterative image reconstruction methods for fully 3D multispectral bioluminescence tomography for applications in small animal imaging. Our forward model uses a diffusion approximation for optically inhomogeneous tissue, which we solve using a finite element method (FEM). We examine two approaches to incorporating the forward model into the solution of the inverse problem. In a conventional direct calculation approach one computes the full forward model by repeated solution of the FEM problem, once for each potential source location. We describe an alternative on-the-fly approach where one does not explicitly solve for the full forward model. Instead, the solution to the forward problem is included implicitly in the formulation of the inverse problem, and the FEM problem is solved at each iteration for the current image estimate. We evaluate the convergence speeds of several representative iterative algorithms. We compare the computation cost of those two approaches, concluding that the on-the-fly approach can lead to substantial reductions in total cost when combined with a rapidly converging iterative algorithm.

Original languageEnglish (US)
Pages (from-to)3921-3942
Number of pages22
JournalPhysics in Medicine and Biology
Volume53
Issue number14
DOIs
StatePublished - Jul 21 2008

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Bioluminescence
bioluminescence
Computer-Assisted Image Processing
image reconstruction
Image reconstruction
Tomography
tomography
finite element method
Inverse problems
Finite element method
costs
Costs and Cost Analysis
iteration
animals
Costs
Animals
Research Design
Tissue
Imaging techniques
formulations

ASJC Scopus subject areas

  • Biomedical Engineering
  • Physics and Astronomy (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Fast iterative image reconstruction methods for fully 3D multispectral bioluminescence tomography. / Ahn, Sangtae; Chaudhari, Abhijit; Darvas, Felix; Bouman, Charles A.; Leahy, Richard M.

In: Physics in Medicine and Biology, Vol. 53, No. 14, 21.07.2008, p. 3921-3942.

Research output: Contribution to journalArticle

Ahn, Sangtae ; Chaudhari, Abhijit ; Darvas, Felix ; Bouman, Charles A. ; Leahy, Richard M. / Fast iterative image reconstruction methods for fully 3D multispectral bioluminescence tomography. In: Physics in Medicine and Biology. 2008 ; Vol. 53, No. 14. pp. 3921-3942.
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