Fast and easy drying method for the preparation of activated [ 18F]fluoride using polymer cartridge

Jai Seo, Byoung Se Lee, Sang Ju Lee, Seung Jun Oh, Dae Yoon Chi

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

An efficient nucleophilic [18F]fluorination has been studied to reduce byproducts and preparation time. Instead of conventional aqueous solution of K2CO3-K222, several organic solution containing inert organic salts were used to release [18F]fluoride ion and anion bases captured in the polymer cartridge, concluding that methanol solution is the best choice. Comparing to azeotropic drying process, one min was sufficient to remove methanol completely, resulting in about 10% radioactivity saving by reducing drying time. The polymer cartridge, Chromafix® (PS-HCO3) was pretreated with several anion bases to displace pre-loaded bicarbonate base. Phosphate bases showed better results than carbonate bases in terms of lower basicity. tert-Butanol solvent used as a reaction media played another critical role in nucleophilic [ 18F]fluorination by suppressing eliminated side product. Consequent [18F]fluorination under the present condition afforded fast preparation of reaction solution and high radiochemical yields (98% radio-TLC, 84% RCY) with 94% of precursor remained.

Original languageEnglish (US)
Pages (from-to)71-76
Number of pages6
JournalBulletin of the Korean Chemical Society
Volume32
Issue number1
DOIs
StatePublished - Jan 20 2011
Externally publishedYes

Fingerprint

Fluorides
Fluorination
Drying
Polymers
Anions
Methanol
tert-Butyl Alcohol
Carbonates
Radioactivity
Alkalinity
Bicarbonates
Byproducts
Salts
Phosphates
Ions

Keywords

  • [F]fluoride
  • Drying method
  • Nucleophilic fluorination
  • PET
  • Polymer cartridge

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Fast and easy drying method for the preparation of activated [ 18F]fluoride using polymer cartridge. / Seo, Jai; Lee, Byoung Se; Lee, Sang Ju; Oh, Seung Jun; Chi, Dae Yoon.

In: Bulletin of the Korean Chemical Society, Vol. 32, No. 1, 20.01.2011, p. 71-76.

Research output: Contribution to journalArticle

Seo, Jai ; Lee, Byoung Se ; Lee, Sang Ju ; Oh, Seung Jun ; Chi, Dae Yoon. / Fast and easy drying method for the preparation of activated [ 18F]fluoride using polymer cartridge. In: Bulletin of the Korean Chemical Society. 2011 ; Vol. 32, No. 1. pp. 71-76.
@article{ea191eff436b4ce0b7d9593844277f27,
title = "Fast and easy drying method for the preparation of activated [ 18F]fluoride using polymer cartridge",
abstract = "An efficient nucleophilic [18F]fluorination has been studied to reduce byproducts and preparation time. Instead of conventional aqueous solution of K2CO3-K222, several organic solution containing inert organic salts were used to release [18F]fluoride ion and anion bases captured in the polymer cartridge, concluding that methanol solution is the best choice. Comparing to azeotropic drying process, one min was sufficient to remove methanol completely, resulting in about 10{\%} radioactivity saving by reducing drying time. The polymer cartridge, Chromafix{\circledR} (PS-HCO3) was pretreated with several anion bases to displace pre-loaded bicarbonate base. Phosphate bases showed better results than carbonate bases in terms of lower basicity. tert-Butanol solvent used as a reaction media played another critical role in nucleophilic [ 18F]fluorination by suppressing eliminated side product. Consequent [18F]fluorination under the present condition afforded fast preparation of reaction solution and high radiochemical yields (98{\%} radio-TLC, 84{\%} RCY) with 94{\%} of precursor remained.",
keywords = "[F]fluoride, Drying method, Nucleophilic fluorination, PET, Polymer cartridge",
author = "Jai Seo and Lee, {Byoung Se} and Lee, {Sang Ju} and Oh, {Seung Jun} and Chi, {Dae Yoon}",
year = "2011",
month = "1",
day = "20",
doi = "10.5012/bkcs.2011.32.1.71",
language = "English (US)",
volume = "32",
pages = "71--76",
journal = "Bulletin of the Korean Chemical Society",
issn = "0253-2964",
publisher = "Korean Chemical Society",
number = "1",

}

TY - JOUR

T1 - Fast and easy drying method for the preparation of activated [ 18F]fluoride using polymer cartridge

AU - Seo, Jai

AU - Lee, Byoung Se

AU - Lee, Sang Ju

AU - Oh, Seung Jun

AU - Chi, Dae Yoon

PY - 2011/1/20

Y1 - 2011/1/20

N2 - An efficient nucleophilic [18F]fluorination has been studied to reduce byproducts and preparation time. Instead of conventional aqueous solution of K2CO3-K222, several organic solution containing inert organic salts were used to release [18F]fluoride ion and anion bases captured in the polymer cartridge, concluding that methanol solution is the best choice. Comparing to azeotropic drying process, one min was sufficient to remove methanol completely, resulting in about 10% radioactivity saving by reducing drying time. The polymer cartridge, Chromafix® (PS-HCO3) was pretreated with several anion bases to displace pre-loaded bicarbonate base. Phosphate bases showed better results than carbonate bases in terms of lower basicity. tert-Butanol solvent used as a reaction media played another critical role in nucleophilic [ 18F]fluorination by suppressing eliminated side product. Consequent [18F]fluorination under the present condition afforded fast preparation of reaction solution and high radiochemical yields (98% radio-TLC, 84% RCY) with 94% of precursor remained.

AB - An efficient nucleophilic [18F]fluorination has been studied to reduce byproducts and preparation time. Instead of conventional aqueous solution of K2CO3-K222, several organic solution containing inert organic salts were used to release [18F]fluoride ion and anion bases captured in the polymer cartridge, concluding that methanol solution is the best choice. Comparing to azeotropic drying process, one min was sufficient to remove methanol completely, resulting in about 10% radioactivity saving by reducing drying time. The polymer cartridge, Chromafix® (PS-HCO3) was pretreated with several anion bases to displace pre-loaded bicarbonate base. Phosphate bases showed better results than carbonate bases in terms of lower basicity. tert-Butanol solvent used as a reaction media played another critical role in nucleophilic [ 18F]fluorination by suppressing eliminated side product. Consequent [18F]fluorination under the present condition afforded fast preparation of reaction solution and high radiochemical yields (98% radio-TLC, 84% RCY) with 94% of precursor remained.

KW - [F]fluoride

KW - Drying method

KW - Nucleophilic fluorination

KW - PET

KW - Polymer cartridge

UR - http://www.scopus.com/inward/record.url?scp=78951471342&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78951471342&partnerID=8YFLogxK

U2 - 10.5012/bkcs.2011.32.1.71

DO - 10.5012/bkcs.2011.32.1.71

M3 - Article

AN - SCOPUS:78951471342

VL - 32

SP - 71

EP - 76

JO - Bulletin of the Korean Chemical Society

JF - Bulletin of the Korean Chemical Society

SN - 0253-2964

IS - 1

ER -