Fast and accurate detector module crystal blur and mis-position error modeling for PET imaging

Ting Xia, Huini Du, Wenli Wang, Kent Burr, Jian Zhou, Karthik Balakrishnan, Hongwei Ye, Xiaofeng Niu, Changguo Ji, Evren Asma, Jinyi Qi, Daniel Gagnon

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We propose a new method for modeling the detector module crystal positioning-blur and mis-positioning errors based on the detector modules' flood histograms (crystal position map) and crystal segmentation maps and use simulations for validation. First, a statistical simulation tool is used to simulate signal pathways from gamma photons in crystals to photo-multiplier tube pulses and then to digitized data for flood histograms. Next, a mixture of generalized 2D skewed Gaussian functions is used to model the simulated flood histogram for each crystal. A fitted flood histogram is generated with the estimated parameters from the simulated flood histogram. By applying the crystal segmentation map to the results of the fit, a crystal crosstalk matrix is calculated to characterize the probability distribution of the detector module crystal positioning-blur and mis-position error. The crystal crosstalk is then used to generate the probability distribution function (pdf) of the crystal blur and mis-position error for each detector module. To evaluate our method, we applied the pdf on GATE-simulated singles and/or paired list-mode data for point sources at various locations without considering crystal blur and mis-position error. The FWHM of each point in the reconstructed images was evaluated and compared to that of those reconstructed without applying the model. Preliminary results show that the method could efficiently model the resolution degradation. The advantage of the proposed method is that it can use real measurement data and can potentially include all resolution degradation effects in the detector module and detecting electronics. It is also fast and feasible for multiple repeated studies because it does not require time-consuming photon-tracking simulations. This approach is suitable both for accurate data generation after photon tracking through the phantom/patient and also for real detector PSF modeling inside image reconstruction algorithms.

Original languageEnglish (US)
Title of host publication2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781479960972
DOIs
StatePublished - Mar 10 2016
EventIEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014 - Seattle, United States
Duration: Nov 8 2014Nov 15 2014

Other

OtherIEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014
CountryUnited States
CitySeattle
Period11/8/1411/15/14

Fingerprint

position errors
modules
Photons
detectors
crystals
histograms
positioning
Computer-Assisted Image Processing
Information Storage and Retrieval
probability distribution functions
crosstalk
Signal Transduction
photons
degradation
GARP Atlantic Tropical Experiment
simulation
photomultiplier tubes
image reconstruction
lists
point sources

ASJC Scopus subject areas

  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

Cite this

Xia, T., Du, H., Wang, W., Burr, K., Zhou, J., Balakrishnan, K., ... Gagnon, D. (2016). Fast and accurate detector module crystal blur and mis-position error modeling for PET imaging. In 2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014 [7430832] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NSSMIC.2014.7430832

Fast and accurate detector module crystal blur and mis-position error modeling for PET imaging. / Xia, Ting; Du, Huini; Wang, Wenli; Burr, Kent; Zhou, Jian; Balakrishnan, Karthik; Ye, Hongwei; Niu, Xiaofeng; Ji, Changguo; Asma, Evren; Qi, Jinyi; Gagnon, Daniel.

2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014. Institute of Electrical and Electronics Engineers Inc., 2016. 7430832.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Xia, T, Du, H, Wang, W, Burr, K, Zhou, J, Balakrishnan, K, Ye, H, Niu, X, Ji, C, Asma, E, Qi, J & Gagnon, D 2016, Fast and accurate detector module crystal blur and mis-position error modeling for PET imaging. in 2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014., 7430832, Institute of Electrical and Electronics Engineers Inc., IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014, Seattle, United States, 11/8/14. https://doi.org/10.1109/NSSMIC.2014.7430832
Xia T, Du H, Wang W, Burr K, Zhou J, Balakrishnan K et al. Fast and accurate detector module crystal blur and mis-position error modeling for PET imaging. In 2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014. Institute of Electrical and Electronics Engineers Inc. 2016. 7430832 https://doi.org/10.1109/NSSMIC.2014.7430832
Xia, Ting ; Du, Huini ; Wang, Wenli ; Burr, Kent ; Zhou, Jian ; Balakrishnan, Karthik ; Ye, Hongwei ; Niu, Xiaofeng ; Ji, Changguo ; Asma, Evren ; Qi, Jinyi ; Gagnon, Daniel. / Fast and accurate detector module crystal blur and mis-position error modeling for PET imaging. 2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014. Institute of Electrical and Electronics Engineers Inc., 2016.
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