Familial pseudoxanthoma elasticum associated with multiple comedones

Melody Maarouf, Victoria R. Sharon, Raja K Sivamani, Neha Prakash, T. H. Bipin, Tracy Davis, Vivian Y. Shi

Research output: Contribution to journalArticlepeer-review


Pseudoxanthoma elasticum (PXE) is an autosomal recessive disorder characterized by atypical elastic fibers that causes connective tissue abnormalities of the skin, eyes, and heart, among other organs. The disorder is rare, with a classic presentation of yellow-orange cobblestone-like papules on flexural areas, lax skin, ocular degeneration, and moribund vasculature in multiple organs. There is wide variability in the presentation of the affected organs [1]. We present two sisters with classic cutaneous findings of PXE with the additional unusual findings of numerous open comedones on the neck. To our knowledge, this is the first report of numerous open comedones in familial PXE.

Original languageEnglish (US)
JournalDermatology Online Journal
Issue number9
StatePublished - 2017


  • Acneiform
  • Comedones
  • Connective tissue
  • Elastin
  • Pseudoxanthoma elasticum

ASJC Scopus subject areas

  • Dermatology


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