Familial autoimmune thyroid disease as a risk factor for regression in children with autism spectrum disorder: A CPEA study

Cynthia A. Molloy, Ardythe L. Morrow, Jareen Meinzen-Derr, Geraldine Dawson, Raphael Bernier, Michelle Dunn, Susan L. Hyman, William M. McMahon, Julie Goudie-Nice, Susan Hepburn, Nancy Minshew, Sally J Rogers, Marian Sigman, M. Anne Spence, Helen Tager-Flusberg, Fred R. Volkmar, Catherine Lord

Research output: Contribution to journalArticle

72 Scopus citations

Abstract

A multicenter study of 308 children with Autism Spectrum Disorder (ASD) was conducted through the Collaborative Programs of Excellence in Autism (CPEA), sponsored by the National Institute of Child Health and Human Development, to compare the family history of autoimmune disorders in children with ASD with and without a history of regression. A history of regression was determined from the results of the Autism Diagnostic Interview-Revised (ADI-R). Family history of autoimmune disorders was obtained by telephone interview. Regression was significantly associated with a family history of autoimmune disorders (adjusted OR=1.89; 95% CI: 1.17, 3.10). The only specific autoimmune disorder found to be associated with regression was autoimmune thyroid disease (adjusted OR=2.09; 95% CI: 1.28, 3.41).

Original languageEnglish (US)
Pages (from-to)317-324
Number of pages8
JournalJournal of Autism and Developmental Disorders
Volume36
Issue number3
DOIs
StatePublished - Apr 2006

Keywords

  • ASD
  • Autism
  • Autoimmune
  • Family history
  • Regression

ASJC Scopus subject areas

  • Psychology(all)
  • Developmental and Educational Psychology

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    Molloy, C. A., Morrow, A. L., Meinzen-Derr, J., Dawson, G., Bernier, R., Dunn, M., Hyman, S. L., McMahon, W. M., Goudie-Nice, J., Hepburn, S., Minshew, N., Rogers, S. J., Sigman, M., Spence, M. A., Tager-Flusberg, H., Volkmar, F. R., & Lord, C. (2006). Familial autoimmune thyroid disease as a risk factor for regression in children with autism spectrum disorder: A CPEA study. Journal of Autism and Developmental Disorders, 36(3), 317-324. https://doi.org/10.1007/s10803-005-0071-0