Abstract
Objective. To develop diagnostiic criteria for a familial form of antiphospholipid antibody syndrome (APS), identify families with >1 affected member, examine possible modes of inheritance, and determine linkage to potential candidate genes. Methods. Family members of probands with primary APS were analyzed for clinical and laboratory abnormalities associated with APS. Families with ≥2 affected members were analyzed by segregation analysis and typed for candidate genetic markers. Results. Seven families were identified. Thirty of 101 family members met diagnostic criteria for APS. Segregation studies rejected both environmental and autosomal recessive models, and the data were best fit by either a dominant or codominant model. Linkage analysis showed independent segregation of APS and several candidate genes. Conclusion. Clinical and laboratory criteria are essential to identify the spectrum of disease associated with APS. We believe a set of criteria was developed that can precisely define affected family members with APS. Modeling studies utilizing these criteria strongly support a genetic basis for disease in families with APS and suggest that a susceptibility gene is inherited in an autosomal dominant pattern. However, in these families, APS was not linked with HLA, Fas, or other candidate genes, including β2- glycoprotein I, HLA, T cell receptor β chain, Ig heavy chain, antithrombin III, Fas ligand, factor V, complement factor H, IgK, and Fas.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 318-327 |
| Number of pages | 10 |
| Journal | Arthritis and Rheumatism |
| Volume | 42 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1999 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
- Rheumatology
Cite this
Familial antiphospholipid antibody syndrome : Criteria for disease and evidence for autosomal dominant inheritance. / Goel, Niti; Ortel, Thomas L.; Bali, Deeksha; Anderson, Joshua P.; Gourley, Ian S.; Smith, Howard; Morris, Colleen A.; DeSimone, Muriel; Ware Branch, D.; Ford, Peter; Berdeaux, Donald; Roubey, Robert A S; Kostyu, Donna D.; Kingsmore, Stephen F.; Thiel, Tracy; Amos, Christopher; Seldin, Michael F.
In: Arthritis and Rheumatism, Vol. 42, No. 2, 02.1999, p. 318-327.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Familial antiphospholipid antibody syndrome
T2 - Criteria for disease and evidence for autosomal dominant inheritance
AU - Goel, Niti
AU - Ortel, Thomas L.
AU - Bali, Deeksha
AU - Anderson, Joshua P.
AU - Gourley, Ian S.
AU - Smith, Howard
AU - Morris, Colleen A.
AU - DeSimone, Muriel
AU - Ware Branch, D.
AU - Ford, Peter
AU - Berdeaux, Donald
AU - Roubey, Robert A S
AU - Kostyu, Donna D.
AU - Kingsmore, Stephen F.
AU - Thiel, Tracy
AU - Amos, Christopher
AU - Seldin, Michael F
PY - 1999/2
Y1 - 1999/2
N2 - Objective. To develop diagnostiic criteria for a familial form of antiphospholipid antibody syndrome (APS), identify families with >1 affected member, examine possible modes of inheritance, and determine linkage to potential candidate genes. Methods. Family members of probands with primary APS were analyzed for clinical and laboratory abnormalities associated with APS. Families with ≥2 affected members were analyzed by segregation analysis and typed for candidate genetic markers. Results. Seven families were identified. Thirty of 101 family members met diagnostic criteria for APS. Segregation studies rejected both environmental and autosomal recessive models, and the data were best fit by either a dominant or codominant model. Linkage analysis showed independent segregation of APS and several candidate genes. Conclusion. Clinical and laboratory criteria are essential to identify the spectrum of disease associated with APS. We believe a set of criteria was developed that can precisely define affected family members with APS. Modeling studies utilizing these criteria strongly support a genetic basis for disease in families with APS and suggest that a susceptibility gene is inherited in an autosomal dominant pattern. However, in these families, APS was not linked with HLA, Fas, or other candidate genes, including β2- glycoprotein I, HLA, T cell receptor β chain, Ig heavy chain, antithrombin III, Fas ligand, factor V, complement factor H, IgK, and Fas.
AB - Objective. To develop diagnostiic criteria for a familial form of antiphospholipid antibody syndrome (APS), identify families with >1 affected member, examine possible modes of inheritance, and determine linkage to potential candidate genes. Methods. Family members of probands with primary APS were analyzed for clinical and laboratory abnormalities associated with APS. Families with ≥2 affected members were analyzed by segregation analysis and typed for candidate genetic markers. Results. Seven families were identified. Thirty of 101 family members met diagnostic criteria for APS. Segregation studies rejected both environmental and autosomal recessive models, and the data were best fit by either a dominant or codominant model. Linkage analysis showed independent segregation of APS and several candidate genes. Conclusion. Clinical and laboratory criteria are essential to identify the spectrum of disease associated with APS. We believe a set of criteria was developed that can precisely define affected family members with APS. Modeling studies utilizing these criteria strongly support a genetic basis for disease in families with APS and suggest that a susceptibility gene is inherited in an autosomal dominant pattern. However, in these families, APS was not linked with HLA, Fas, or other candidate genes, including β2- glycoprotein I, HLA, T cell receptor β chain, Ig heavy chain, antithrombin III, Fas ligand, factor V, complement factor H, IgK, and Fas.
UR - http://www.scopus.com/inward/record.url?scp=0033007174&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033007174&partnerID=8YFLogxK
U2 - 10.1002/1529-0131(199902)42:2<318::AID-ANR15>3.0.CO;2-5
DO - 10.1002/1529-0131(199902)42:2<318::AID-ANR15>3.0.CO;2-5
M3 - Article
C2 - 10025927
AN - SCOPUS:0033007174
VL - 42
SP - 318
EP - 327
JO - Arthritis and Rheumatology
JF - Arthritis and Rheumatology
SN - 2326-5191
IS - 2
ER -