Failure to protect Mus musculus against Plasmodium berghei with footpad injections of killed parasites incorporated in complete Freund's adjuvant

William Reisen, T. C. Hillis

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The stimulation of cell mediated immunity by the injection of antigen from killed parasites incorporated in complete Freund's adjuvant did not protect Mus musculus from the erythrocytic stages of Plasmodium berghei. Agglutinating antibodies could not be detected, but delayed hypersensitivity was demonstrable. Apparently thymocyte sensitization alone was not sufficient to afford protection.

Original languageEnglish (US)
Pages (from-to)937-940
Number of pages4
JournalJournal of Parasitology
Volume61
Issue number5
DOIs
StatePublished - Jan 1 1975
Externally publishedYes

Fingerprint

erythrocytic stage
Plasmodium berghei
thymocytes
delayed hypersensitivity
Freund's Adjuvant
Delayed Hypersensitivity
Mus musculus
Thymocytes
immunity
antigen
Cellular Immunity
cell-mediated immunity
adjuvants
antibody
parasite
Parasites
injection
antigens
Antigens
parasites

ASJC Scopus subject areas

  • Parasitology
  • Ecology, Evolution, Behavior and Systematics

Cite this

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abstract = "The stimulation of cell mediated immunity by the injection of antigen from killed parasites incorporated in complete Freund's adjuvant did not protect Mus musculus from the erythrocytic stages of Plasmodium berghei. Agglutinating antibodies could not be detected, but delayed hypersensitivity was demonstrable. Apparently thymocyte sensitization alone was not sufficient to afford protection.",
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