Failure of vitamin E in clinical trials: Is gamma-tocopherol the answer?

Sridevi Devaraj, Ishwarlal Jialal

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


Oxidative stress and inflammation play a crucial role in atherosclerosis. However, prospective clinical trials of dietary antioxidants with anti-inflammatory properties, such as α-tocopherol (AT), have not yielded positive results. AT supplementation decreases γ-tocopherol (GT) levels. GT is an antioxidant with potent anti-inflammatory activity, and plasma GT levels are inversely associated with cardiovascular diseases. Thus, studies using pure GT, alone or in conjunction with AT, will elucidate its utility in cardiovascular disease prevention.

Original languageEnglish (US)
Pages (from-to)290-293
Number of pages4
JournalNutrition Reviews
Issue number8
StatePublished - Aug 2005


  • Antioxidant
  • Inflammation
  • Nitrative stress
  • Oxidative stress
  • Tocopherol

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science


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