Failure of vitamin E in clinical trials: Is gamma-tocopherol the answer?

Sridevi Devaraj, Ishwarlal Jialal

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Oxidative stress and inflammation play a crucial role in atherosclerosis. However, prospective clinical trials of dietary antioxidants with anti-inflammatory properties, such as α-tocopherol (AT), have not yielded positive results. AT supplementation decreases γ-tocopherol (GT) levels. GT is an antioxidant with potent anti-inflammatory activity, and plasma GT levels are inversely associated with cardiovascular diseases. Thus, studies using pure GT, alone or in conjunction with AT, will elucidate its utility in cardiovascular disease prevention.

Original languageEnglish (US)
Pages (from-to)290-293
Number of pages4
JournalNutrition Reviews
Volume63
Issue number8
DOIs
StatePublished - Aug 2005

Fingerprint

gamma-Tocopherol
Tocopherols
gamma-tocopherol
Vitamin E
tocopherols
vitamin E
clinical trials
Clinical Trials
anti-inflammatory activity
cardiovascular diseases
Anti-Inflammatory Agents
Cardiovascular Diseases
Antioxidants
antioxidants
disease prevention
atherosclerosis
prospective studies
Atherosclerosis
Oxidative Stress
oxidative stress

Keywords

  • Antioxidant
  • Inflammation
  • Nitrative stress
  • Oxidative stress
  • Tocopherol

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Failure of vitamin E in clinical trials : Is gamma-tocopherol the answer? / Devaraj, Sridevi; Jialal, Ishwarlal.

In: Nutrition Reviews, Vol. 63, No. 8, 08.2005, p. 290-293.

Research output: Contribution to journalArticle

Devaraj, Sridevi ; Jialal, Ishwarlal. / Failure of vitamin E in clinical trials : Is gamma-tocopherol the answer?. In: Nutrition Reviews. 2005 ; Vol. 63, No. 8. pp. 290-293.
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