Factors that promote macrophage homing to adipose tissue in metabolic syndrome

Ishwarlal Jialal, Beverley Adams-Huet, Sridevi Devaraj

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Metabolic syndrome (MetS), a common cardio-metabolic cluster, predisposes to both increased cardiovascular disease and diabetes. Both adipose tissue and monocyte/macrophages contribute to the increased inflammation in MetS. However there are sparse data on factors that determine macrophage recruitment into adipose tissue (AT). In this preliminary report in patients with MetS, without the confounding of diabetes and cardiovascular diseases, we show that plasma resistin, soluble CD14 and monocyte p38 MAP kinase activity correlate significantly with AT macrophage density and hence could be important biomediators of macrophage homing to AT in MetS. However larger studies are required to confirm these novel findings and elucidate other important factors.

Original languageEnglish (US)
Pages (from-to)1434-1436
Number of pages3
JournalJournal of Diabetes and its Complications
Volume30
Issue number8
DOIs
StatePublished - Nov 1 2016

Fingerprint

Adipose Tissue
Macrophages
Monocytes
Cardiovascular Diseases
Resistin
p38 Mitogen-Activated Protein Kinases
Inflammation

Keywords

  • Adipose tissue
  • Inflammation
  • Metabolic syndrome
  • MONOCYTES
  • Resistin
  • Soluble CD14

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Factors that promote macrophage homing to adipose tissue in metabolic syndrome. / Jialal, Ishwarlal; Adams-Huet, Beverley; Devaraj, Sridevi.

In: Journal of Diabetes and its Complications, Vol. 30, No. 8, 01.11.2016, p. 1434-1436.

Research output: Contribution to journalArticle

Jialal, Ishwarlal ; Adams-Huet, Beverley ; Devaraj, Sridevi. / Factors that promote macrophage homing to adipose tissue in metabolic syndrome. In: Journal of Diabetes and its Complications. 2016 ; Vol. 30, No. 8. pp. 1434-1436.
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