Factors that affect tissue-engineered skeletal muscle function and physiology

Alastair Khodabukus, Keith Baar

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

Tissue-engineered skeletal muscle has the promise to be a tool for studying physiology, screening muscle-active drugs, and clinical replacement of damaged muscle. To maximize the potential benefits of engineered muscle, it is important to understand the factors required for tissue formation and how these affect muscle function. In this review, we evaluate how biomaterials, cell source, media components, and bioreactor interventions impact muscle function and phenotype.

Original languageEnglish (US)
Pages (from-to)159-168
Number of pages10
JournalCells Tissues Organs
Volume202
Issue number3-4
DOIs
StatePublished - Nov 1 2016

Keywords

  • Cell culture
  • Contractile properties
  • Force
  • Muscle function
  • Skeletal muscle
  • Tissue engineering

ASJC Scopus subject areas

  • Anatomy
  • Histology

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