Factors related to declining luteal function in women during the menopausal transition

Nanette Santoro, S. L. Crawford, W. L. Lasley, J. L. Luborsky, K. A. Matthews, D. McConnell, J. F. Randolph, Ellen B Gold, G. A. Greendale, S. G. Korenman, L. Powell, M. F. Sowers, G. Weiss

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Context: Reproductive hormones are incompletely characterized during the menopause transition (MT). Hypothesis: Increased anovulation and decreased progesterone accompany progress through the MT. Design: The Daily Hormone Study (DHS) of the Study of Women's Health Across the Nation (SWAN) included 848 women aged 43-53 yr at baseline who collected daily urine for one cycle or up to 50 d annually for 3 yr. Main Outcome Measures: LH, FSH, estrone conjugates, and pregnanediol glucuronide levels were assessed. Cycles were classified by presumed luteal (ovulatory) status and bleeding. Hormones were related to time in study, age, menopausal status, and selected variables. Results: Ovulatory-appearing cycles declined from 80.9% at baseline to 64.7% by the third assessment (H3). Cycles presumed anovulatory and not ending with bleeding by 50 d (anovulatory/nonbleeding) increased from 8.4 to 24% by H3 and were associated with progress to early perimenopause [odds ratio (OR) = 2.66; confidence interval (CI) = 1.17-6.04] or late perimenopause (OR = 56.21; CI = 18.79-168.12; P < 0.0001), African-American ethnicity (OR = 1.91; CI = 1.06-3.43), and less than high school education (OR = 3.51; CI = 1.62-7.62). Anovulatory cycles ending with bleeding remained at about 10% from baseline to H3; compared with ovulatory cycles, they were associated with obesity (OR = 4.68; CI = 1.33-16.52) and more than high school education (OR = 2.12; CI = 1.22-3.69; P = 0.02). Serum estradiol in both the highest and lowest categories was associated with anovulatory/nonbleeding collections. Pregnanediol glucuronide decreased 6.6% for each year on study. Insulin sensitivity measures did not relate strongly to menstrual cycle hormones. Conclusions: Anovulation without bleeding represents progression of the MT. A small but detectable decrease in luteal progesterone excretion occurs as women progress through the MT.

Original languageEnglish (US)
Pages (from-to)1711-1721
Number of pages11
JournalJournal of Clinical Endocrinology and Metabolism
Volume93
Issue number5
DOIs
StatePublished - May 2008

Fingerprint

Corpus Luteum
Odds Ratio
Pregnanediol
Hormones
Confidence Intervals
Menopause
Hemorrhage
Glucuronides
Perimenopause
Anovulation
Progesterone
Education
Estrone
Estradiol
Women's Health
Insulin
Menstrual Cycle
African Americans
Insulin Resistance
Obesity

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Santoro, N., Crawford, S. L., Lasley, W. L., Luborsky, J. L., Matthews, K. A., McConnell, D., ... Weiss, G. (2008). Factors related to declining luteal function in women during the menopausal transition. Journal of Clinical Endocrinology and Metabolism, 93(5), 1711-1721. https://doi.org/10.1210/jc.2007-2165

Factors related to declining luteal function in women during the menopausal transition. / Santoro, Nanette; Crawford, S. L.; Lasley, W. L.; Luborsky, J. L.; Matthews, K. A.; McConnell, D.; Randolph, J. F.; Gold, Ellen B; Greendale, G. A.; Korenman, S. G.; Powell, L.; Sowers, M. F.; Weiss, G.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 93, No. 5, 05.2008, p. 1711-1721.

Research output: Contribution to journalArticle

Santoro, N, Crawford, SL, Lasley, WL, Luborsky, JL, Matthews, KA, McConnell, D, Randolph, JF, Gold, EB, Greendale, GA, Korenman, SG, Powell, L, Sowers, MF & Weiss, G 2008, 'Factors related to declining luteal function in women during the menopausal transition', Journal of Clinical Endocrinology and Metabolism, vol. 93, no. 5, pp. 1711-1721. https://doi.org/10.1210/jc.2007-2165
Santoro, Nanette ; Crawford, S. L. ; Lasley, W. L. ; Luborsky, J. L. ; Matthews, K. A. ; McConnell, D. ; Randolph, J. F. ; Gold, Ellen B ; Greendale, G. A. ; Korenman, S. G. ; Powell, L. ; Sowers, M. F. ; Weiss, G. / Factors related to declining luteal function in women during the menopausal transition. In: Journal of Clinical Endocrinology and Metabolism. 2008 ; Vol. 93, No. 5. pp. 1711-1721.
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abstract = "Context: Reproductive hormones are incompletely characterized during the menopause transition (MT). Hypothesis: Increased anovulation and decreased progesterone accompany progress through the MT. Design: The Daily Hormone Study (DHS) of the Study of Women's Health Across the Nation (SWAN) included 848 women aged 43-53 yr at baseline who collected daily urine for one cycle or up to 50 d annually for 3 yr. Main Outcome Measures: LH, FSH, estrone conjugates, and pregnanediol glucuronide levels were assessed. Cycles were classified by presumed luteal (ovulatory) status and bleeding. Hormones were related to time in study, age, menopausal status, and selected variables. Results: Ovulatory-appearing cycles declined from 80.9{\%} at baseline to 64.7{\%} by the third assessment (H3). Cycles presumed anovulatory and not ending with bleeding by 50 d (anovulatory/nonbleeding) increased from 8.4 to 24{\%} by H3 and were associated with progress to early perimenopause [odds ratio (OR) = 2.66; confidence interval (CI) = 1.17-6.04] or late perimenopause (OR = 56.21; CI = 18.79-168.12; P < 0.0001), African-American ethnicity (OR = 1.91; CI = 1.06-3.43), and less than high school education (OR = 3.51; CI = 1.62-7.62). Anovulatory cycles ending with bleeding remained at about 10{\%} from baseline to H3; compared with ovulatory cycles, they were associated with obesity (OR = 4.68; CI = 1.33-16.52) and more than high school education (OR = 2.12; CI = 1.22-3.69; P = 0.02). Serum estradiol in both the highest and lowest categories was associated with anovulatory/nonbleeding collections. Pregnanediol glucuronide decreased 6.6{\%} for each year on study. Insulin sensitivity measures did not relate strongly to menstrual cycle hormones. Conclusions: Anovulation without bleeding represents progression of the MT. A small but detectable decrease in luteal progesterone excretion occurs as women progress through the MT.",
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AU - Crawford, S. L.

AU - Lasley, W. L.

AU - Luborsky, J. L.

AU - Matthews, K. A.

AU - McConnell, D.

AU - Randolph, J. F.

AU - Gold, Ellen B

AU - Greendale, G. A.

AU - Korenman, S. G.

AU - Powell, L.

AU - Sowers, M. F.

AU - Weiss, G.

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N2 - Context: Reproductive hormones are incompletely characterized during the menopause transition (MT). Hypothesis: Increased anovulation and decreased progesterone accompany progress through the MT. Design: The Daily Hormone Study (DHS) of the Study of Women's Health Across the Nation (SWAN) included 848 women aged 43-53 yr at baseline who collected daily urine for one cycle or up to 50 d annually for 3 yr. Main Outcome Measures: LH, FSH, estrone conjugates, and pregnanediol glucuronide levels were assessed. Cycles were classified by presumed luteal (ovulatory) status and bleeding. Hormones were related to time in study, age, menopausal status, and selected variables. Results: Ovulatory-appearing cycles declined from 80.9% at baseline to 64.7% by the third assessment (H3). Cycles presumed anovulatory and not ending with bleeding by 50 d (anovulatory/nonbleeding) increased from 8.4 to 24% by H3 and were associated with progress to early perimenopause [odds ratio (OR) = 2.66; confidence interval (CI) = 1.17-6.04] or late perimenopause (OR = 56.21; CI = 18.79-168.12; P < 0.0001), African-American ethnicity (OR = 1.91; CI = 1.06-3.43), and less than high school education (OR = 3.51; CI = 1.62-7.62). Anovulatory cycles ending with bleeding remained at about 10% from baseline to H3; compared with ovulatory cycles, they were associated with obesity (OR = 4.68; CI = 1.33-16.52) and more than high school education (OR = 2.12; CI = 1.22-3.69; P = 0.02). Serum estradiol in both the highest and lowest categories was associated with anovulatory/nonbleeding collections. Pregnanediol glucuronide decreased 6.6% for each year on study. Insulin sensitivity measures did not relate strongly to menstrual cycle hormones. Conclusions: Anovulation without bleeding represents progression of the MT. A small but detectable decrease in luteal progesterone excretion occurs as women progress through the MT.

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